MAP3K4 kinase action and dual role in cancer
Abstract It is commonly known that the MAPK pathway is involved in translating environmental inputs, regulating downstream reactions, and maintaining the intrinsic dynamic balance. Numerous essential elements and regulatory processes are included in this pathway, which are essential to its functiona...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Springer
2024-04-01
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| Series: | Discover Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s12672-024-00961-x |
| _version_ | 1827291435384176640 |
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| author | Yuxin Huang Guanwen Wang Ningning Zhang Xiaohua Zeng |
| author_facet | Yuxin Huang Guanwen Wang Ningning Zhang Xiaohua Zeng |
| author_sort | Yuxin Huang |
| collection | DOAJ |
| description | Abstract It is commonly known that the MAPK pathway is involved in translating environmental inputs, regulating downstream reactions, and maintaining the intrinsic dynamic balance. Numerous essential elements and regulatory processes are included in this pathway, which are essential to its functionality. Among these, MAP3K4, a member of the serine/threonine kinases family, plays vital roles throughout the organism's life cycle, including the regulation of apoptosis and autophagy. Moreover, MAP3K4 can interact with key partners like GADD45, which affects organism's growth and development. Notably, MAP3K4 functions as both a tumor promotor and suppressor, being activated by a variety of factors and triggering diverse downstream pathways that differently influence cancer progression. The aim of this study is to provide a brief overview of physiological functions of MAP3K4 and shed light on its contradictory roles in tumorigenesis. |
| first_indexed | 2024-04-24T12:38:03Z |
| format | Article |
| id | doaj.art-23bca6e5d2ae42bebeb89db4324e35e6 |
| institution | Directory Open Access Journal |
| issn | 2730-6011 |
| language | English |
| last_indexed | 2024-04-24T12:38:03Z |
| publishDate | 2024-04-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj.art-23bca6e5d2ae42bebeb89db4324e35e62024-04-07T11:22:38ZengSpringerDiscover Oncology2730-60112024-04-0115111610.1007/s12672-024-00961-xMAP3K4 kinase action and dual role in cancerYuxin Huang0Guanwen Wang1Ningning Zhang2Xiaohua Zeng3Department of Breast Cancer Center, Chongqing University Cancer Hospital, School of Medicine, Chongqing UniversityDepartment of Breast Cancer Center, Chongqing University Cancer HospitalDepartment of Breast Cancer Center, Chongqing University Cancer HospitalDepartment of Breast Cancer Center, Chongqing University Cancer Hospital, School of Medicine, Chongqing UniversityAbstract It is commonly known that the MAPK pathway is involved in translating environmental inputs, regulating downstream reactions, and maintaining the intrinsic dynamic balance. Numerous essential elements and regulatory processes are included in this pathway, which are essential to its functionality. Among these, MAP3K4, a member of the serine/threonine kinases family, plays vital roles throughout the organism's life cycle, including the regulation of apoptosis and autophagy. Moreover, MAP3K4 can interact with key partners like GADD45, which affects organism's growth and development. Notably, MAP3K4 functions as both a tumor promotor and suppressor, being activated by a variety of factors and triggering diverse downstream pathways that differently influence cancer progression. The aim of this study is to provide a brief overview of physiological functions of MAP3K4 and shed light on its contradictory roles in tumorigenesis.https://doi.org/10.1007/s12672-024-00961-xMAP3K4MAPK pathwaysBinding partnersOrganism developmentCancer |
| spellingShingle | Yuxin Huang Guanwen Wang Ningning Zhang Xiaohua Zeng MAP3K4 kinase action and dual role in cancer Discover Oncology MAP3K4 MAPK pathways Binding partners Organism development Cancer |
| title | MAP3K4 kinase action and dual role in cancer |
| title_full | MAP3K4 kinase action and dual role in cancer |
| title_fullStr | MAP3K4 kinase action and dual role in cancer |
| title_full_unstemmed | MAP3K4 kinase action and dual role in cancer |
| title_short | MAP3K4 kinase action and dual role in cancer |
| title_sort | map3k4 kinase action and dual role in cancer |
| topic | MAP3K4 MAPK pathways Binding partners Organism development Cancer |
| url | https://doi.org/10.1007/s12672-024-00961-x |
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