Malignant Melanoma with Concurrent BRAF E586K and NRAS Q81K Mutations
Cutaneous melanoma is an aggressive malignant tumor of melanocytes which accounts for 80% of skin cancer-related deaths. A number of driver mutations have been identified in melanoma, with the mutually exclusive BRAF V600E and NRAS Q61A mutations together accounting for roughly 70% of mutations. Sim...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2014-05-01
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| Series: | Case Reports in Oncology |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/362788 |
| _version_ | 1811224909028786176 |
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| author | Rodney Shackelford Maressa Pollen Moise Vora Tamara T. Jusion James Cotelingam Binu Nair |
| author_facet | Rodney Shackelford Maressa Pollen Moise Vora Tamara T. Jusion James Cotelingam Binu Nair |
| author_sort | Rodney Shackelford |
| collection | DOAJ |
| description | Cutaneous melanoma is an aggressive malignant tumor of melanocytes which accounts for 80% of skin cancer-related deaths. A number of driver mutations have been identified in melanoma, with the mutually exclusive BRAF V600E and NRAS Q61A mutations together accounting for roughly 70% of mutations. Simultaneous BRAF V600E and NRAS Q61A mutations in melanoma are rare, with evidence suggesting that up to 2.9% (2/69) of primary cutaneous melanomas carry both mutations. Here we describe a 42-year-old man with concurrent BRAF E586K and NRAS Q81K driver mutations. To our knowledge, this is the first description of these driver mutations occurring simultaneously in primary cutaneous melanoma. |
| first_indexed | 2024-04-12T08:56:50Z |
| format | Article |
| id | doaj.art-23bebe7d63854a2d8478a89ee110c116 |
| institution | Directory Open Access Journal |
| issn | 1662-6575 |
| language | English |
| last_indexed | 2024-04-12T08:56:50Z |
| publishDate | 2014-05-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Oncology |
| spelling | doaj.art-23bebe7d63854a2d8478a89ee110c1162022-12-22T03:39:21ZengKarger PublishersCase Reports in Oncology1662-65752014-05-017229730010.1159/000362788362788Malignant Melanoma with Concurrent BRAF E586K and NRAS Q81K MutationsRodney ShackelfordMaressa PollenMoise VoraTamara T. JusionJames CotelingamBinu NairCutaneous melanoma is an aggressive malignant tumor of melanocytes which accounts for 80% of skin cancer-related deaths. A number of driver mutations have been identified in melanoma, with the mutually exclusive BRAF V600E and NRAS Q61A mutations together accounting for roughly 70% of mutations. Simultaneous BRAF V600E and NRAS Q61A mutations in melanoma are rare, with evidence suggesting that up to 2.9% (2/69) of primary cutaneous melanomas carry both mutations. Here we describe a 42-year-old man with concurrent BRAF E586K and NRAS Q81K driver mutations. To our knowledge, this is the first description of these driver mutations occurring simultaneously in primary cutaneous melanoma.http://www.karger.com/Article/FullText/362788Cutaneous melanomaConcurrent BRAF E586K and NRAS Q81K mutationsSkin cancer |
| spellingShingle | Rodney Shackelford Maressa Pollen Moise Vora Tamara T. Jusion James Cotelingam Binu Nair Malignant Melanoma with Concurrent BRAF E586K and NRAS Q81K Mutations Case Reports in Oncology Cutaneous melanoma Concurrent BRAF E586K and NRAS Q81K mutations Skin cancer |
| title | Malignant Melanoma with Concurrent BRAF E586K and NRAS Q81K Mutations |
| title_full | Malignant Melanoma with Concurrent BRAF E586K and NRAS Q81K Mutations |
| title_fullStr | Malignant Melanoma with Concurrent BRAF E586K and NRAS Q81K Mutations |
| title_full_unstemmed | Malignant Melanoma with Concurrent BRAF E586K and NRAS Q81K Mutations |
| title_short | Malignant Melanoma with Concurrent BRAF E586K and NRAS Q81K Mutations |
| title_sort | malignant melanoma with concurrent braf e586k and nras q81k mutations |
| topic | Cutaneous melanoma Concurrent BRAF E586K and NRAS Q81K mutations Skin cancer |
| url | http://www.karger.com/Article/FullText/362788 |
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