Altered brain functional network topology in Obsessive-Compulsive Disorder: A comparison of patients with varying severity of depressive symptoms and the impact on psychosocial functioning
Background: Obsessive-compulsive disorder (OCD) is associated with psychosocial impairment, which can be exacerbated by depressive symptoms. In this study, we employed graph theory analysis to investigate the association among neuroimaging, clinical features, and psychosocial functioning in OCD pati...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | NeuroImage: Clinical |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S221315822300236X |
| _version_ | 1797454332765929472 |
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| author | Zhihan Xu Minyao Xie Zhongqi Wang Haochen Chen Xuedi Zhang Wangyue Li Wenjing Jiang Na Liu Ning Zhang |
| author_facet | Zhihan Xu Minyao Xie Zhongqi Wang Haochen Chen Xuedi Zhang Wangyue Li Wenjing Jiang Na Liu Ning Zhang |
| author_sort | Zhihan Xu |
| collection | DOAJ |
| description | Background: Obsessive-compulsive disorder (OCD) is associated with psychosocial impairment, which can be exacerbated by depressive symptoms. In this study, we employed graph theory analysis to investigate the association among neuroimaging, clinical features, and psychosocial functioning in OCD patients, with a specific focus on the differential impact of depressive symptoms. Methods: 216 OCD patients were divided into two subgroups based on depressive symptoms. Resting-state functional MRI data were acquired from a subset of 106 OCD patients along with 77 matched healthy controls (HCs). We analyzed the topological characteristics of the entire brain and the cognition-related subnetworks and performed Pearson correlation analyses to further explore the relationship with psychosocial functioning. Results: OCD patients with more severe depressive symptoms exhibited greater impairment across all dimensions of psychosocial functioning. Graph theory analysis revealed more pronounced reductions in network efficiency within the entire brain, the default mode network (DMN), and the cingulo-opercular network (CON) among patients with non or mild depressive symptoms. Lower nodal efficiency and degree centrality of the right superior temporal gyrus (STG) were found in OCD patients and these variables were positively correlated with psychosocial functioning impairment. Conclusions: This study revealed that the presence of depressive symptoms generally exacerbated psychosocial functioning impairment in OCD patients. Abnormalities in the functional integration of the entire brain, the DMN, and the CON in OCD patients may comprise the basis of cognitive deficits, while dysfunction of the right STG may affect the psychosocial functioning through its role in emotion, intention perception, and insight. |
| first_indexed | 2024-03-09T15:35:45Z |
| format | Article |
| id | doaj.art-23bf4817e2da439bba5ddd63f0d5259d |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-03-09T15:35:45Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-23bf4817e2da439bba5ddd63f0d5259d2023-11-26T05:12:35ZengElsevierNeuroImage: Clinical2213-15822023-01-0140103545Altered brain functional network topology in Obsessive-Compulsive Disorder: A comparison of patients with varying severity of depressive symptoms and the impact on psychosocial functioningZhihan Xu0Minyao Xie1Zhongqi Wang2Haochen Chen3Xuedi Zhang4Wangyue Li5Wenjing Jiang6Na Liu7Ning Zhang8The Affiliated Brain Hospital of Nanjing Medical University, 264 Guangzhou Road, Nanjing 210029, ChinaThe Affiliated Brain Hospital of Nanjing Medical University, 264 Guangzhou Road, Nanjing 210029, ChinaThe Affiliated Brain Hospital of Nanjing Medical University, 264 Guangzhou Road, Nanjing 210029, ChinaThe Affiliated Brain Hospital of Nanjing Medical University, 264 Guangzhou Road, Nanjing 210029, ChinaThe Affiliated Brain Hospital of Nanjing Medical University, 264 Guangzhou Road, Nanjing 210029, ChinaThe Affiliated Brain Hospital of Nanjing Medical University, 264 Guangzhou Road, Nanjing 210029, ChinaThe Affiliated Brain Hospital of Nanjing Medical University, 264 Guangzhou Road, Nanjing 210029, ChinaDepartment of Medical Psychology, The Affiliated Brain Hospital of Nanjing Medical University, 264 Guangzhou Road, Nanjing 210029, China; Corresponding authors.The Affiliated Brain Hospital of Nanjing Medical University, 264 Guangzhou Road, Nanjing 210029, China; Corresponding authors.Background: Obsessive-compulsive disorder (OCD) is associated with psychosocial impairment, which can be exacerbated by depressive symptoms. In this study, we employed graph theory analysis to investigate the association among neuroimaging, clinical features, and psychosocial functioning in OCD patients, with a specific focus on the differential impact of depressive symptoms. Methods: 216 OCD patients were divided into two subgroups based on depressive symptoms. Resting-state functional MRI data were acquired from a subset of 106 OCD patients along with 77 matched healthy controls (HCs). We analyzed the topological characteristics of the entire brain and the cognition-related subnetworks and performed Pearson correlation analyses to further explore the relationship with psychosocial functioning. Results: OCD patients with more severe depressive symptoms exhibited greater impairment across all dimensions of psychosocial functioning. Graph theory analysis revealed more pronounced reductions in network efficiency within the entire brain, the default mode network (DMN), and the cingulo-opercular network (CON) among patients with non or mild depressive symptoms. Lower nodal efficiency and degree centrality of the right superior temporal gyrus (STG) were found in OCD patients and these variables were positively correlated with psychosocial functioning impairment. Conclusions: This study revealed that the presence of depressive symptoms generally exacerbated psychosocial functioning impairment in OCD patients. Abnormalities in the functional integration of the entire brain, the DMN, and the CON in OCD patients may comprise the basis of cognitive deficits, while dysfunction of the right STG may affect the psychosocial functioning through its role in emotion, intention perception, and insight.http://www.sciencedirect.com/science/article/pii/S221315822300236XObsessive-compulsive disorderDepressive symptomsGraph theoryCognition-related networkPsychosocial functioning |
| spellingShingle | Zhihan Xu Minyao Xie Zhongqi Wang Haochen Chen Xuedi Zhang Wangyue Li Wenjing Jiang Na Liu Ning Zhang Altered brain functional network topology in Obsessive-Compulsive Disorder: A comparison of patients with varying severity of depressive symptoms and the impact on psychosocial functioning NeuroImage: Clinical Obsessive-compulsive disorder Depressive symptoms Graph theory Cognition-related network Psychosocial functioning |
| title | Altered brain functional network topology in Obsessive-Compulsive Disorder: A comparison of patients with varying severity of depressive symptoms and the impact on psychosocial functioning |
| title_full | Altered brain functional network topology in Obsessive-Compulsive Disorder: A comparison of patients with varying severity of depressive symptoms and the impact on psychosocial functioning |
| title_fullStr | Altered brain functional network topology in Obsessive-Compulsive Disorder: A comparison of patients with varying severity of depressive symptoms and the impact on psychosocial functioning |
| title_full_unstemmed | Altered brain functional network topology in Obsessive-Compulsive Disorder: A comparison of patients with varying severity of depressive symptoms and the impact on psychosocial functioning |
| title_short | Altered brain functional network topology in Obsessive-Compulsive Disorder: A comparison of patients with varying severity of depressive symptoms and the impact on psychosocial functioning |
| title_sort | altered brain functional network topology in obsessive compulsive disorder a comparison of patients with varying severity of depressive symptoms and the impact on psychosocial functioning |
| topic | Obsessive-compulsive disorder Depressive symptoms Graph theory Cognition-related network Psychosocial functioning |
| url | http://www.sciencedirect.com/science/article/pii/S221315822300236X |
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