<i>CYP7A1</i>, <i>NPC1L1</i>, <i>ABCB1</i>, and <i>CD36</i> Polymorphisms Associated with Coenzyme Q<sub>10</sub> Availability Affect the Subjective Quality of Life Score (SF-36) after Long-Term CoQ<sub>10</sub> Supplementation in Women
The single nucleotide polymorphisms (SNPs) rs3808607, rs2072183, rs2032582, and rs1761667 are associated with coenzyme Q<sub>10</sub> (CoQ<sub>10</sub>) bioavailability in women after long-term CoQ<sub>10</sub> supplementation. However, the beneficial aspects of t...
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MDPI AG
2022-06-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/13/2579 |
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| author | Michiyo Takahashi Tetsu Kinoshita Koutatsu Maruyama Toshikazu Suzuki |
| author_facet | Michiyo Takahashi Tetsu Kinoshita Koutatsu Maruyama Toshikazu Suzuki |
| author_sort | Michiyo Takahashi |
| collection | DOAJ |
| description | The single nucleotide polymorphisms (SNPs) rs3808607, rs2072183, rs2032582, and rs1761667 are associated with coenzyme Q<sub>10</sub> (CoQ<sub>10</sub>) bioavailability in women after long-term CoQ<sub>10</sub> supplementation. However, the beneficial aspects of the association between these SNPs and CoQ<sub>10</sub> supplementation remain unknown. We investigated their relationship using the subjective quality of life score SF-36 by reanalyzing previous data from 92 study participants who were receiving ubiquinol (a reduced form of CoQ<sub>10</sub>) supplementation for 1 year. Two-way repeated-measures analysis of variance revealed a significant interaction between rs1761667 and the SF-36 scores of role physical (<i>p</i> = 0.016) and mental health (<i>p</i> = 0.017) in women. Subgrouping of participants based on the above four SNPs revealed significant interactions between these SNPs and the SF-36 scores of general health (<i>p</i> = 0.045), role emotional (<i>p</i> = 0.008), and mental health (<i>p</i> = 0.019) and increased serum CoQ<sub>10</sub> levels (<i>p</i> = 0.008), suggesting that the benefits of CoQ<sub>10</sub> supplementation, especially in terms of psychological parameters, are genotype-dependent in women. However, significant interactions were not observed in men. Therefore, inclusion of SNP subgrouping information in clinical trials of CoQ<sub>10</sub> supplementation may provide conclusive evidence supporting other beneficial health effects exerted by the association between these SNPs and CoQ<sub>10</sub> on women. |
| first_indexed | 2024-03-09T12:41:36Z |
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| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T12:41:36Z |
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| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-23bf82bf58e742699f4bc4e85a996d622023-11-30T22:17:26ZengMDPI AGNutrients2072-66432022-06-011413257910.3390/nu14132579<i>CYP7A1</i>, <i>NPC1L1</i>, <i>ABCB1</i>, and <i>CD36</i> Polymorphisms Associated with Coenzyme Q<sub>10</sub> Availability Affect the Subjective Quality of Life Score (SF-36) after Long-Term CoQ<sub>10</sub> Supplementation in WomenMichiyo Takahashi0Tetsu Kinoshita1Koutatsu Maruyama2Toshikazu Suzuki3Graduate School of Human Ecology, Wayo Women’s University, 2-3-1 Konodai, Ichikawa 272-8533, Chiba, JapanDepartment of Bioscience, Graduate School of Agriculture, Ehime University, 3-5-7 Tarumi, Matsuyama 790-8566, Ehime, JapanDepartment of Bioscience, Graduate School of Agriculture, Ehime University, 3-5-7 Tarumi, Matsuyama 790-8566, Ehime, JapanGraduate School of Human Ecology, Wayo Women’s University, 2-3-1 Konodai, Ichikawa 272-8533, Chiba, JapanThe single nucleotide polymorphisms (SNPs) rs3808607, rs2072183, rs2032582, and rs1761667 are associated with coenzyme Q<sub>10</sub> (CoQ<sub>10</sub>) bioavailability in women after long-term CoQ<sub>10</sub> supplementation. However, the beneficial aspects of the association between these SNPs and CoQ<sub>10</sub> supplementation remain unknown. We investigated their relationship using the subjective quality of life score SF-36 by reanalyzing previous data from 92 study participants who were receiving ubiquinol (a reduced form of CoQ<sub>10</sub>) supplementation for 1 year. Two-way repeated-measures analysis of variance revealed a significant interaction between rs1761667 and the SF-36 scores of role physical (<i>p</i> = 0.016) and mental health (<i>p</i> = 0.017) in women. Subgrouping of participants based on the above four SNPs revealed significant interactions between these SNPs and the SF-36 scores of general health (<i>p</i> = 0.045), role emotional (<i>p</i> = 0.008), and mental health (<i>p</i> = 0.019) and increased serum CoQ<sub>10</sub> levels (<i>p</i> = 0.008), suggesting that the benefits of CoQ<sub>10</sub> supplementation, especially in terms of psychological parameters, are genotype-dependent in women. However, significant interactions were not observed in men. Therefore, inclusion of SNP subgrouping information in clinical trials of CoQ<sub>10</sub> supplementation may provide conclusive evidence supporting other beneficial health effects exerted by the association between these SNPs and CoQ<sub>10</sub> on women.https://www.mdpi.com/2072-6643/14/13/2579coenzyme Q<sub>10</sub>cholesterolsingle nucleotide polymorphisms (SNPs)Medical Outcome Study 36-Item Short-Form Health Survey (SF-36) |
| spellingShingle | Michiyo Takahashi Tetsu Kinoshita Koutatsu Maruyama Toshikazu Suzuki <i>CYP7A1</i>, <i>NPC1L1</i>, <i>ABCB1</i>, and <i>CD36</i> Polymorphisms Associated with Coenzyme Q<sub>10</sub> Availability Affect the Subjective Quality of Life Score (SF-36) after Long-Term CoQ<sub>10</sub> Supplementation in Women Nutrients coenzyme Q<sub>10</sub> cholesterol single nucleotide polymorphisms (SNPs) Medical Outcome Study 36-Item Short-Form Health Survey (SF-36) |
| title | <i>CYP7A1</i>, <i>NPC1L1</i>, <i>ABCB1</i>, and <i>CD36</i> Polymorphisms Associated with Coenzyme Q<sub>10</sub> Availability Affect the Subjective Quality of Life Score (SF-36) after Long-Term CoQ<sub>10</sub> Supplementation in Women |
| title_full | <i>CYP7A1</i>, <i>NPC1L1</i>, <i>ABCB1</i>, and <i>CD36</i> Polymorphisms Associated with Coenzyme Q<sub>10</sub> Availability Affect the Subjective Quality of Life Score (SF-36) after Long-Term CoQ<sub>10</sub> Supplementation in Women |
| title_fullStr | <i>CYP7A1</i>, <i>NPC1L1</i>, <i>ABCB1</i>, and <i>CD36</i> Polymorphisms Associated with Coenzyme Q<sub>10</sub> Availability Affect the Subjective Quality of Life Score (SF-36) after Long-Term CoQ<sub>10</sub> Supplementation in Women |
| title_full_unstemmed | <i>CYP7A1</i>, <i>NPC1L1</i>, <i>ABCB1</i>, and <i>CD36</i> Polymorphisms Associated with Coenzyme Q<sub>10</sub> Availability Affect the Subjective Quality of Life Score (SF-36) after Long-Term CoQ<sub>10</sub> Supplementation in Women |
| title_short | <i>CYP7A1</i>, <i>NPC1L1</i>, <i>ABCB1</i>, and <i>CD36</i> Polymorphisms Associated with Coenzyme Q<sub>10</sub> Availability Affect the Subjective Quality of Life Score (SF-36) after Long-Term CoQ<sub>10</sub> Supplementation in Women |
| title_sort | i cyp7a1 i i npc1l1 i i abcb1 i and i cd36 i polymorphisms associated with coenzyme q sub 10 sub availability affect the subjective quality of life score sf 36 after long term coq sub 10 sub supplementation in women |
| topic | coenzyme Q<sub>10</sub> cholesterol single nucleotide polymorphisms (SNPs) Medical Outcome Study 36-Item Short-Form Health Survey (SF-36) |
| url | https://www.mdpi.com/2072-6643/14/13/2579 |
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