Recent Advances in Two-Dimensional MXene-Based Electrochemical Biosensors for Sweat Analysis
Sweat, a biofluid secreted naturally from the eccrine glands of the human body, is rich in several electrolytes, metabolites, biomolecules, and even xenobiotics that enter the body through other means. Recent studies indicate a high correlation between the analytes’ concentrations in the sweat and t...
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MDPI AG
2023-06-01
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author | Selvaganapathy Ganesan Kalaipriya Ramajayam Thangavelu Kokulnathan Arunkumar Palaniappan |
author_facet | Selvaganapathy Ganesan Kalaipriya Ramajayam Thangavelu Kokulnathan Arunkumar Palaniappan |
author_sort | Selvaganapathy Ganesan |
collection | DOAJ |
description | Sweat, a biofluid secreted naturally from the eccrine glands of the human body, is rich in several electrolytes, metabolites, biomolecules, and even xenobiotics that enter the body through other means. Recent studies indicate a high correlation between the analytes’ concentrations in the sweat and the blood, opening up sweat as a medium for disease diagnosis and other general health monitoring applications. However, low concentration of analytes in sweat is a significant limitation, requiring high-performing sensors for this application. Electrochemical sensors, due to their high sensitivity, low cost, and miniaturization, play a crucial role in realizing the potential of sweat as a key sensing medium. MXenes, recently developed anisotropic two-dimensional atomic-layered nanomaterials composed of early transition metal carbides or nitrides, are currently being explored as a material of choice for electrochemical sensors. Their large surface area, tunable electrical properties, excellent mechanical strength, good dispersibility, and biocompatibility make them attractive for bio-electrochemical sensing platforms. This review presents the recent progress made in MXene-based bio-electrochemical sensors such as wearable, implantable, and microfluidic sensors and their applications in disease diagnosis and developing point-of-care sensing platforms. Finally, the paper discusses the challenges and limitations of MXenes as a material of choice in bio-electrochemical sensors and future perspectives on this exciting material for sweat-sensing applications. |
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issn | 1420-3049 |
language | English |
last_indexed | 2024-03-11T02:06:59Z |
publishDate | 2023-06-01 |
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spelling | doaj.art-23bf8e8f65634687a5734ba755d64c2b2023-11-18T11:48:03ZengMDPI AGMolecules1420-30492023-06-012812461710.3390/molecules28124617Recent Advances in Two-Dimensional MXene-Based Electrochemical Biosensors for Sweat AnalysisSelvaganapathy Ganesan0Kalaipriya Ramajayam1Thangavelu Kokulnathan2Arunkumar Palaniappan3Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore 632014, Tamil Nadu, IndiaDepartment of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore 632014, Tamil Nadu, IndiaDepartment of Electro-Optical Engineering, National Taipei University of Technology, Taipei 106, TaiwanCentre for Biomaterials, Cellular and Molecular Theranostics, Vellore Institute of Technology, Vellore 632014, Tamil Nadu, IndiaSweat, a biofluid secreted naturally from the eccrine glands of the human body, is rich in several electrolytes, metabolites, biomolecules, and even xenobiotics that enter the body through other means. Recent studies indicate a high correlation between the analytes’ concentrations in the sweat and the blood, opening up sweat as a medium for disease diagnosis and other general health monitoring applications. However, low concentration of analytes in sweat is a significant limitation, requiring high-performing sensors for this application. Electrochemical sensors, due to their high sensitivity, low cost, and miniaturization, play a crucial role in realizing the potential of sweat as a key sensing medium. MXenes, recently developed anisotropic two-dimensional atomic-layered nanomaterials composed of early transition metal carbides or nitrides, are currently being explored as a material of choice for electrochemical sensors. Their large surface area, tunable electrical properties, excellent mechanical strength, good dispersibility, and biocompatibility make them attractive for bio-electrochemical sensing platforms. This review presents the recent progress made in MXene-based bio-electrochemical sensors such as wearable, implantable, and microfluidic sensors and their applications in disease diagnosis and developing point-of-care sensing platforms. Finally, the paper discusses the challenges and limitations of MXenes as a material of choice in bio-electrochemical sensors and future perspectives on this exciting material for sweat-sensing applications.https://www.mdpi.com/1420-3049/28/12/4617point-of-carediagnosticwearable sensorglucose monitoring |
spellingShingle | Selvaganapathy Ganesan Kalaipriya Ramajayam Thangavelu Kokulnathan Arunkumar Palaniappan Recent Advances in Two-Dimensional MXene-Based Electrochemical Biosensors for Sweat Analysis Molecules point-of-care diagnostic wearable sensor glucose monitoring |
title | Recent Advances in Two-Dimensional MXene-Based Electrochemical Biosensors for Sweat Analysis |
title_full | Recent Advances in Two-Dimensional MXene-Based Electrochemical Biosensors for Sweat Analysis |
title_fullStr | Recent Advances in Two-Dimensional MXene-Based Electrochemical Biosensors for Sweat Analysis |
title_full_unstemmed | Recent Advances in Two-Dimensional MXene-Based Electrochemical Biosensors for Sweat Analysis |
title_short | Recent Advances in Two-Dimensional MXene-Based Electrochemical Biosensors for Sweat Analysis |
title_sort | recent advances in two dimensional mxene based electrochemical biosensors for sweat analysis |
topic | point-of-care diagnostic wearable sensor glucose monitoring |
url | https://www.mdpi.com/1420-3049/28/12/4617 |
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