Respiratory training in older women: Unravelling central and peripheral hemodynamic slow oscillatory patterns
We hypothesized that inspiratory muscle training (IMT) increases the respiratory-induced low-frequency oscillations of mean blood pressure (MBP) and middle cerebral artery blood velocity (MCAv), upregulating cerebrovascular function in older women. Firstly, participants were recorded with free-breat...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-02-01
|
| Series: | Experimental Gerontology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0531556522003679 |
| _version_ | 1827897281239580672 |
|---|---|
| author | Gabriel Dias Rodrigues Antonio Claudio Lucas da Nobrega Pedro Paulo da Silva Soares |
| author_facet | Gabriel Dias Rodrigues Antonio Claudio Lucas da Nobrega Pedro Paulo da Silva Soares |
| author_sort | Gabriel Dias Rodrigues |
| collection | DOAJ |
| description | We hypothesized that inspiratory muscle training (IMT) increases the respiratory-induced low-frequency oscillations of mean blood pressure (MBP) and middle cerebral artery blood velocity (MCAv), upregulating cerebrovascular function in older women. Firstly, participants were recorded with free-breathing (FB) and then breathed at a slow-paced frequency (0.1 Hz; DB test) supported by sonorous metronome feedback. Blood pressure was recorded using finger photoplethysmography method, ECG, and respiration using a thoracic belt. To obtain the MCAv a transcranial ultrasound Doppler device was used. Spectral analysis of MBP, R-R intervals, and mean MCAv time series was obtained by an autoregressive model. The transfer function analysis (TFA) was employed to calculate the coherence, gain, and phase. After that, older women were enrolled in a randomized controlled protocol, the IMT-group (n = 8; 64 ± 3 years-old) performed IMT at 50 % of maximal inspiratory pressure (MIP), and Sham-group, a placebo training at 5 % MIP (Sham-group; n = 6; 66 ± 3 years-old). Participants breathed against an inspiratory resistance twice a day for 4-weeks. DB test is repeated post IMT and Sham interventions. IMT-group, compared to Sham-group, augmented tidal volume responses to DB (Sham-group 1.03 ± 0.41 vs. IMT-group 1.61 ± 0.56 L; p = 0.04), increased respiratory-induced MBP (Sham-group 26.37 ± 4.46 vs. IMT-group 48.21 ± 3.15 mmHg2; p = 0.04) and MCAv (Sham-group 14.16 ± 31.26 vs. IMT-group 79.90 ± 21.76 cm2s−2; p = 0.03) slow oscillations, and reduced TFA gain (Sham-group 2.46 ± 1.32 vs. IMT-group 1.78 ± 1.30 cm·s−1.mmHg−1; p = 0.01). Our findings suggest that IMT increases the respiratory-induced oscillations in MBP and MCAv signals and reduces TFA gain. It seems compatible with an improved dynamic cerebrovascular regulation following IMT in older women. |
| first_indexed | 2024-03-12T22:46:54Z |
| format | Article |
| id | doaj.art-23c09fdccee3461faf1aa927d24f9572 |
| institution | Directory Open Access Journal |
| issn | 1873-6815 |
| language | English |
| last_indexed | 2024-03-12T22:46:54Z |
| publishDate | 2023-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Experimental Gerontology |
| spelling | doaj.art-23c09fdccee3461faf1aa927d24f95722023-07-21T04:58:40ZengElsevierExperimental Gerontology1873-68152023-02-01172112058Respiratory training in older women: Unravelling central and peripheral hemodynamic slow oscillatory patternsGabriel Dias Rodrigues0Antonio Claudio Lucas da Nobrega1Pedro Paulo da Silva Soares2Department of Physiology and Pharmacology, Fluminense Federal University, Niterói, RJ, Brazil; INCT (In)Activity and Exercise, CNPq, National Institute for Science and Technology, Niterói, RJ, Brazil; Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy; Corresponding author at: Department of Physiology and Pharmacology, Fluminense Federal University, Rua Professor Hernani Pires de Melo, 101 - São Domingos, Niterói CEP 24210-130, RJ, Brazil.Department of Physiology and Pharmacology, Fluminense Federal University, Niterói, RJ, Brazil; INCT (In)Activity and Exercise, CNPq, National Institute for Science and Technology, Niterói, RJ, BrazilDepartment of Physiology and Pharmacology, Fluminense Federal University, Niterói, RJ, Brazil; INCT (In)Activity and Exercise, CNPq, National Institute for Science and Technology, Niterói, RJ, BrazilWe hypothesized that inspiratory muscle training (IMT) increases the respiratory-induced low-frequency oscillations of mean blood pressure (MBP) and middle cerebral artery blood velocity (MCAv), upregulating cerebrovascular function in older women. Firstly, participants were recorded with free-breathing (FB) and then breathed at a slow-paced frequency (0.1 Hz; DB test) supported by sonorous metronome feedback. Blood pressure was recorded using finger photoplethysmography method, ECG, and respiration using a thoracic belt. To obtain the MCAv a transcranial ultrasound Doppler device was used. Spectral analysis of MBP, R-R intervals, and mean MCAv time series was obtained by an autoregressive model. The transfer function analysis (TFA) was employed to calculate the coherence, gain, and phase. After that, older women were enrolled in a randomized controlled protocol, the IMT-group (n = 8; 64 ± 3 years-old) performed IMT at 50 % of maximal inspiratory pressure (MIP), and Sham-group, a placebo training at 5 % MIP (Sham-group; n = 6; 66 ± 3 years-old). Participants breathed against an inspiratory resistance twice a day for 4-weeks. DB test is repeated post IMT and Sham interventions. IMT-group, compared to Sham-group, augmented tidal volume responses to DB (Sham-group 1.03 ± 0.41 vs. IMT-group 1.61 ± 0.56 L; p = 0.04), increased respiratory-induced MBP (Sham-group 26.37 ± 4.46 vs. IMT-group 48.21 ± 3.15 mmHg2; p = 0.04) and MCAv (Sham-group 14.16 ± 31.26 vs. IMT-group 79.90 ± 21.76 cm2s−2; p = 0.03) slow oscillations, and reduced TFA gain (Sham-group 2.46 ± 1.32 vs. IMT-group 1.78 ± 1.30 cm·s−1.mmHg−1; p = 0.01). Our findings suggest that IMT increases the respiratory-induced oscillations in MBP and MCAv signals and reduces TFA gain. It seems compatible with an improved dynamic cerebrovascular regulation following IMT in older women.http://www.sciencedirect.com/science/article/pii/S0531556522003679Cerebrovascular controlTransfer function analysisRespiratory musclesDeep breathingAging |
| spellingShingle | Gabriel Dias Rodrigues Antonio Claudio Lucas da Nobrega Pedro Paulo da Silva Soares Respiratory training in older women: Unravelling central and peripheral hemodynamic slow oscillatory patterns Experimental Gerontology Cerebrovascular control Transfer function analysis Respiratory muscles Deep breathing Aging |
| title | Respiratory training in older women: Unravelling central and peripheral hemodynamic slow oscillatory patterns |
| title_full | Respiratory training in older women: Unravelling central and peripheral hemodynamic slow oscillatory patterns |
| title_fullStr | Respiratory training in older women: Unravelling central and peripheral hemodynamic slow oscillatory patterns |
| title_full_unstemmed | Respiratory training in older women: Unravelling central and peripheral hemodynamic slow oscillatory patterns |
| title_short | Respiratory training in older women: Unravelling central and peripheral hemodynamic slow oscillatory patterns |
| title_sort | respiratory training in older women unravelling central and peripheral hemodynamic slow oscillatory patterns |
| topic | Cerebrovascular control Transfer function analysis Respiratory muscles Deep breathing Aging |
| url | http://www.sciencedirect.com/science/article/pii/S0531556522003679 |
| work_keys_str_mv | AT gabrieldiasrodrigues respiratorytraininginolderwomenunravellingcentralandperipheralhemodynamicslowoscillatorypatterns AT antonioclaudiolucasdanobrega respiratorytraininginolderwomenunravellingcentralandperipheralhemodynamicslowoscillatorypatterns AT pedropaulodasilvasoares respiratorytraininginolderwomenunravellingcentralandperipheralhemodynamicslowoscillatorypatterns |