Unrelated umbilical cord blood can improve the prognosis of haploidentical hematopoietic stem cell transplantation
Abstract Background Haploidentical hematopoietic stem cell transplantation (haplo-HSCT) is widely used as a curative treatment strategy for most types of hematological diseases. However, strategies for enhancing the graft versus leukemia (GVL) effect without aggravating the graft versus host disease...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-09-01
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| Series: | Stem Cell Research & Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13287-022-03170-x |
| _version_ | 1818016894238588928 |
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| author | Ying Yang Ming Zhang Mengqi Li Yingchun Li Wei Yang Zhuogang Liu Hongtao Wang |
| author_facet | Ying Yang Ming Zhang Mengqi Li Yingchun Li Wei Yang Zhuogang Liu Hongtao Wang |
| author_sort | Ying Yang |
| collection | DOAJ |
| description | Abstract Background Haploidentical hematopoietic stem cell transplantation (haplo-HSCT) is widely used as a curative treatment strategy for most types of hematological diseases. However, strategies for enhancing the graft versus leukemia (GVL) effect without aggravating the graft versus host disease (GVHD) effect are still being pursued. Methods A retrospective cohort study was performed to compare the outcomes between combined unrelated umbilical cord blood (UCB-haplo HSCT) and haplo HSCT. Results The results showed that neither acute GVHD (aGVHD) nor chronic GVHD (cGVHD) was increased in the UCB-haplo HSCT group, and the engraftment and infection rates were similar between the two groups. However, overall survival and progression-free survival were significantly improved, while transplantation-related mortality and relapse were significantly decreased in the UCB-haplo HSCT group by both univariate and multivariate analyses. Conclusion Our results indicated that the addition of a UCB unit could improve the prognosis of haplo-HSCT and enhance the GVL effect without increasing the incidence of GVHD. Trial registration The cohort study was retrospectively registered at https://www.chictr.org.cn as ChiCTR2100046681. |
| first_indexed | 2024-04-14T07:18:29Z |
| format | Article |
| id | doaj.art-23c14fb0ba7548c99760b6c66361c49e |
| institution | Directory Open Access Journal |
| issn | 1757-6512 |
| language | English |
| last_indexed | 2024-04-14T07:18:29Z |
| publishDate | 2022-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Stem Cell Research & Therapy |
| spelling | doaj.art-23c14fb0ba7548c99760b6c66361c49e2022-12-22T02:06:14ZengBMCStem Cell Research & Therapy1757-65122022-09-011311910.1186/s13287-022-03170-xUnrelated umbilical cord blood can improve the prognosis of haploidentical hematopoietic stem cell transplantationYing Yang0Ming Zhang1Mengqi Li2Yingchun Li3Wei Yang4Zhuogang Liu5Hongtao Wang6Shengjing Hospital of China Medical UniversityShengjing Hospital of China Medical UniversityShengjing Hospital of China Medical UniversityShengjing Hospital of China Medical UniversityShengjing Hospital of China Medical UniversityShengjing Hospital of China Medical UniversityShengjing Hospital of China Medical UniversityAbstract Background Haploidentical hematopoietic stem cell transplantation (haplo-HSCT) is widely used as a curative treatment strategy for most types of hematological diseases. However, strategies for enhancing the graft versus leukemia (GVL) effect without aggravating the graft versus host disease (GVHD) effect are still being pursued. Methods A retrospective cohort study was performed to compare the outcomes between combined unrelated umbilical cord blood (UCB-haplo HSCT) and haplo HSCT. Results The results showed that neither acute GVHD (aGVHD) nor chronic GVHD (cGVHD) was increased in the UCB-haplo HSCT group, and the engraftment and infection rates were similar between the two groups. However, overall survival and progression-free survival were significantly improved, while transplantation-related mortality and relapse were significantly decreased in the UCB-haplo HSCT group by both univariate and multivariate analyses. Conclusion Our results indicated that the addition of a UCB unit could improve the prognosis of haplo-HSCT and enhance the GVL effect without increasing the incidence of GVHD. Trial registration The cohort study was retrospectively registered at https://www.chictr.org.cn as ChiCTR2100046681.https://doi.org/10.1186/s13287-022-03170-xHaploidentical hematopoietic stem cell transplantationUnrelated umbilical cord bloodGraft versus leukemiaGraft versus host diseasePrognosis |
| spellingShingle | Ying Yang Ming Zhang Mengqi Li Yingchun Li Wei Yang Zhuogang Liu Hongtao Wang Unrelated umbilical cord blood can improve the prognosis of haploidentical hematopoietic stem cell transplantation Stem Cell Research & Therapy Haploidentical hematopoietic stem cell transplantation Unrelated umbilical cord blood Graft versus leukemia Graft versus host disease Prognosis |
| title | Unrelated umbilical cord blood can improve the prognosis of haploidentical hematopoietic stem cell transplantation |
| title_full | Unrelated umbilical cord blood can improve the prognosis of haploidentical hematopoietic stem cell transplantation |
| title_fullStr | Unrelated umbilical cord blood can improve the prognosis of haploidentical hematopoietic stem cell transplantation |
| title_full_unstemmed | Unrelated umbilical cord blood can improve the prognosis of haploidentical hematopoietic stem cell transplantation |
| title_short | Unrelated umbilical cord blood can improve the prognosis of haploidentical hematopoietic stem cell transplantation |
| title_sort | unrelated umbilical cord blood can improve the prognosis of haploidentical hematopoietic stem cell transplantation |
| topic | Haploidentical hematopoietic stem cell transplantation Unrelated umbilical cord blood Graft versus leukemia Graft versus host disease Prognosis |
| url | https://doi.org/10.1186/s13287-022-03170-x |
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