Effects of irradiated glucose solutions on DMBA-induced tumors in rats.
This is a study of the effects of irradiated glucose-saline solutions (60Co, 105 R at a dose rate of 1.7 X 106 R/h) on tumors induced by the intravenous injection of dimethylbenzanthracene (DMBA) in female Sprague-Dawley rats. Each animal received 10 cc intraperitoneal injections of the irradiated...
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| Format: | Article |
| Language: | English |
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Ordem dos Médicos
1981-04-01
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| Series: | Acta Médica Portuguesa |
| Online Access: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3881 |
| _version_ | 1811242486694150144 |
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| author | António M. Baptista Richard M. Roppel |
| author_facet | António M. Baptista Richard M. Roppel |
| author_sort | António M. Baptista |
| collection | DOAJ |
| description |
This is a study of the effects of irradiated glucose-saline solutions (60Co, 105 R at a dose rate of 1.7 X 106 R/h) on tumors induced by the intravenous injection of dimethylbenzanthracene (DMBA) in female Sprague-Dawley rats. Each animal received 10 cc intraperitoneal injections of the irradiated solution spaced over 17 days. As a control two groups of tumor bearing animals were used: one received irradiated isotonic saline solution, and the other unirradiated glucose-saline solution. It could be concluded that those animals which received the irradiated glucose-saline solution experienced retardation of the tumor disease both during and after the treatment period relative to the other groups under study. The results suggest that radiolysis of hexoses can give rise to a carcinostatic compound relatively non-toxic toward non-dividing cells.
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| first_indexed | 2024-04-12T13:52:57Z |
| format | Article |
| id | doaj.art-23c1649b1b59431596a673de46f4aee3 |
| institution | Directory Open Access Journal |
| issn | 0870-399X 1646-0758 |
| language | English |
| last_indexed | 2024-04-12T13:52:57Z |
| publishDate | 1981-04-01 |
| publisher | Ordem dos Médicos |
| record_format | Article |
| series | Acta Médica Portuguesa |
| spelling | doaj.art-23c1649b1b59431596a673de46f4aee32022-12-22T03:30:28ZengOrdem dos MédicosActa Médica Portuguesa0870-399X1646-07581981-04-013210.20344/amp.3881Effects of irradiated glucose solutions on DMBA-induced tumors in rats.António M. Baptista0Richard M. Roppel1Laboratório de Isótopos. Centro de Medicina Nuclear (INIC). Instituto Português de Oncologia de Francisco Gentil. Lisboa. Portugal.Department of Biomechanics. Michigan. State University. East Lansing. Michigan. USA. This is a study of the effects of irradiated glucose-saline solutions (60Co, 105 R at a dose rate of 1.7 X 106 R/h) on tumors induced by the intravenous injection of dimethylbenzanthracene (DMBA) in female Sprague-Dawley rats. Each animal received 10 cc intraperitoneal injections of the irradiated solution spaced over 17 days. As a control two groups of tumor bearing animals were used: one received irradiated isotonic saline solution, and the other unirradiated glucose-saline solution. It could be concluded that those animals which received the irradiated glucose-saline solution experienced retardation of the tumor disease both during and after the treatment period relative to the other groups under study. The results suggest that radiolysis of hexoses can give rise to a carcinostatic compound relatively non-toxic toward non-dividing cells. https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3881 |
| spellingShingle | António M. Baptista Richard M. Roppel Effects of irradiated glucose solutions on DMBA-induced tumors in rats. Acta Médica Portuguesa |
| title | Effects of irradiated glucose solutions on DMBA-induced tumors in rats. |
| title_full | Effects of irradiated glucose solutions on DMBA-induced tumors in rats. |
| title_fullStr | Effects of irradiated glucose solutions on DMBA-induced tumors in rats. |
| title_full_unstemmed | Effects of irradiated glucose solutions on DMBA-induced tumors in rats. |
| title_short | Effects of irradiated glucose solutions on DMBA-induced tumors in rats. |
| title_sort | effects of irradiated glucose solutions on dmba induced tumors in rats |
| url | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3881 |
| work_keys_str_mv | AT antoniombaptista effectsofirradiatedglucosesolutionsondmbainducedtumorsinrats AT richardmroppel effectsofirradiatedglucosesolutionsondmbainducedtumorsinrats |