Epidemiologic Profile of Patients With Epilepsy in a Region of Southeast Brazil: Data From a Referral Center
IntroductionEpilepsy affects about 50 million people worldwide, 80% of whom live in low- and middle-income countries. In Brazil, epidemiological studies are outdated and restricted to specific regions, mostly due to the continental size of country.ObjectiveWe aimed to present the first evidence-base...
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.822537/full |
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| author | Renata Parissi Buainain Renata Parissi Buainain Carlos Tadeu Parisi Oliveira Fernando Augusto Lima Marson Fernando Augusto Lima Marson Manoela Marques Ortega Manoela Marques Ortega |
| author_facet | Renata Parissi Buainain Renata Parissi Buainain Carlos Tadeu Parisi Oliveira Fernando Augusto Lima Marson Fernando Augusto Lima Marson Manoela Marques Ortega Manoela Marques Ortega |
| author_sort | Renata Parissi Buainain |
| collection | DOAJ |
| description | IntroductionEpilepsy affects about 50 million people worldwide, 80% of whom live in low- and middle-income countries. In Brazil, epidemiological studies are outdated and restricted to specific regions, mostly due to the continental size of country.ObjectiveWe aimed to present the first evidence-based study on the epidemiological aspects of individuals with epilepsy, mapping the characteristics of this disease in a referral center in a region of Southeast Brazil.MethodsA retrospective study was carried out from January 2010 to March 2021. Patients were selected according to the International League Against Epilepsy Criteria.ResultsFrom a total of 618 selected patients, 317 (51.3%) were men and 301 (48.7%) were women with an average age of 34.03 ± 20.66 years. The average age at the first seizure was 15.16 ± 17.61 years. The prevalence ratio was 1.30 cases/1,000 habitants. Childhood febrile seizure was present in 44 patients (7.9%) and family history of epilepsy in 231 (37.4%) patients. The predominant type of seizure was focal in 401 (64.9%) patients. The most frequent etiologies were structural in 254 (41.1%) patients and unknown in 238 (38.5%) patients. Most of the patients' treatments were based on anti-seizure drugs in monotherapy [389 (62.9%)] with 398 (64.4%) drug-responsive patients.ConclusionsOur epilepsy prevalence rate was lower than other studies in the Southeast Region of Brazil. In addition, the structural epilepsy type was predominant in our study compared with unknown causes, which is more frequent in other Brazilian regions and worldwide studies. The differences may be attributed to our region, which presents a high prevalence of neuroinfection, specially neurocysticercosis, and a referral center for traumatic brain injury. Moreover, the contrasting results reinforce the need for an adequate epidemiological assessment of epilepsy incidence in a region of Southeast Brazil. |
| first_indexed | 2024-12-12T02:57:20Z |
| format | Article |
| id | doaj.art-23c1dc508b8e4e5d95432f1f20823342 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-12T02:57:20Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-23c1dc508b8e4e5d95432f1f208233422022-12-22T00:40:42ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-05-011310.3389/fneur.2022.822537822537Epidemiologic Profile of Patients With Epilepsy in a Region of Southeast Brazil: Data From a Referral CenterRenata Parissi Buainain0Renata Parissi Buainain1Carlos Tadeu Parisi Oliveira2Fernando Augusto Lima Marson3Fernando Augusto Lima Marson4Manoela Marques Ortega5Manoela Marques Ortega6Laboratory of Cell and Molecular Tumor Biology and Bioactive Compounds, São Francisco University, São Paulo, BrazilLaboratory of Human and Medical Genetics, São Francisco University, São Paulo, BrazilSão Francisco University Hospital, São Paulo, BrazilLaboratory of Cell and Molecular Tumor Biology and Bioactive Compounds, São Francisco University, São Paulo, BrazilLaboratory of Human and Medical Genetics, São Francisco University, São Paulo, BrazilLaboratory of Cell and Molecular Tumor Biology and Bioactive Compounds, São Francisco University, São Paulo, BrazilLaboratory of Human and Medical Genetics, São Francisco University, São Paulo, BrazilIntroductionEpilepsy affects about 50 million people worldwide, 80% of whom live in low- and middle-income countries. In Brazil, epidemiological studies are outdated and restricted to specific regions, mostly due to the continental size of country.ObjectiveWe aimed to present the first evidence-based study on the epidemiological aspects of individuals with epilepsy, mapping the characteristics of this disease in a referral center in a region of Southeast Brazil.MethodsA retrospective study was carried out from January 2010 to March 2021. Patients were selected according to the International League Against Epilepsy Criteria.ResultsFrom a total of 618 selected patients, 317 (51.3%) were men and 301 (48.7%) were women with an average age of 34.03 ± 20.66 years. The average age at the first seizure was 15.16 ± 17.61 years. The prevalence ratio was 1.30 cases/1,000 habitants. Childhood febrile seizure was present in 44 patients (7.9%) and family history of epilepsy in 231 (37.4%) patients. The predominant type of seizure was focal in 401 (64.9%) patients. The most frequent etiologies were structural in 254 (41.1%) patients and unknown in 238 (38.5%) patients. Most of the patients' treatments were based on anti-seizure drugs in monotherapy [389 (62.9%)] with 398 (64.4%) drug-responsive patients.ConclusionsOur epilepsy prevalence rate was lower than other studies in the Southeast Region of Brazil. In addition, the structural epilepsy type was predominant in our study compared with unknown causes, which is more frequent in other Brazilian regions and worldwide studies. The differences may be attributed to our region, which presents a high prevalence of neuroinfection, specially neurocysticercosis, and a referral center for traumatic brain injury. Moreover, the contrasting results reinforce the need for an adequate epidemiological assessment of epilepsy incidence in a region of Southeast Brazil.https://www.frontiersin.org/articles/10.3389/fneur.2022.822537/fullepilepsyepidemiologyprevalenceneurocysticercosisneuroinfectiontraumatic brain injury |
| spellingShingle | Renata Parissi Buainain Renata Parissi Buainain Carlos Tadeu Parisi Oliveira Fernando Augusto Lima Marson Fernando Augusto Lima Marson Manoela Marques Ortega Manoela Marques Ortega Epidemiologic Profile of Patients With Epilepsy in a Region of Southeast Brazil: Data From a Referral Center Frontiers in Neurology epilepsy epidemiology prevalence neurocysticercosis neuroinfection traumatic brain injury |
| title | Epidemiologic Profile of Patients With Epilepsy in a Region of Southeast Brazil: Data From a Referral Center |
| title_full | Epidemiologic Profile of Patients With Epilepsy in a Region of Southeast Brazil: Data From a Referral Center |
| title_fullStr | Epidemiologic Profile of Patients With Epilepsy in a Region of Southeast Brazil: Data From a Referral Center |
| title_full_unstemmed | Epidemiologic Profile of Patients With Epilepsy in a Region of Southeast Brazil: Data From a Referral Center |
| title_short | Epidemiologic Profile of Patients With Epilepsy in a Region of Southeast Brazil: Data From a Referral Center |
| title_sort | epidemiologic profile of patients with epilepsy in a region of southeast brazil data from a referral center |
| topic | epilepsy epidemiology prevalence neurocysticercosis neuroinfection traumatic brain injury |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.822537/full |
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