Oncogenic mutations of PIK3CA lead to increased membrane recruitment driven by reorientation of the ABD, p85 and C-terminus
The PIK3CA gene is one of the most frequently mutated genes in all of human cancer. Here authors describe the molecular mechanisms underlying how different oncogenic mutations in PIK3CA mediate increased activity.
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-35789-6 |
| _version_ | 1797952398097907712 |
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| author | Meredith L. Jenkins Harish Ranga-Prasad Matthew A. H. Parson Noah J. Harris Manoj K. Rathinaswamy John E. Burke |
| author_facet | Meredith L. Jenkins Harish Ranga-Prasad Matthew A. H. Parson Noah J. Harris Manoj K. Rathinaswamy John E. Burke |
| author_sort | Meredith L. Jenkins |
| collection | DOAJ |
| description | The PIK3CA gene is one of the most frequently mutated genes in all of human cancer. Here authors describe the molecular mechanisms underlying how different oncogenic mutations in PIK3CA mediate increased activity. |
| first_indexed | 2024-04-10T22:46:47Z |
| format | Article |
| id | doaj.art-23c2bf5aefcc4d4594519dcac334eb56 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-10T22:46:47Z |
| publishDate | 2023-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-23c2bf5aefcc4d4594519dcac334eb562023-01-15T12:16:26ZengNature PortfolioNature Communications2041-17232023-01-0114111410.1038/s41467-023-35789-6Oncogenic mutations of PIK3CA lead to increased membrane recruitment driven by reorientation of the ABD, p85 and C-terminusMeredith L. Jenkins0Harish Ranga-Prasad1Matthew A. H. Parson2Noah J. Harris3Manoj K. Rathinaswamy4John E. Burke5Department of Biochemistry and Microbiology, University of VictoriaDepartment of Biochemistry and Microbiology, University of VictoriaDepartment of Biochemistry and Microbiology, University of VictoriaDepartment of Biochemistry and Microbiology, University of VictoriaDepartment of Biochemistry and Microbiology, University of VictoriaDepartment of Biochemistry and Microbiology, University of VictoriaThe PIK3CA gene is one of the most frequently mutated genes in all of human cancer. Here authors describe the molecular mechanisms underlying how different oncogenic mutations in PIK3CA mediate increased activity.https://doi.org/10.1038/s41467-023-35789-6 |
| spellingShingle | Meredith L. Jenkins Harish Ranga-Prasad Matthew A. H. Parson Noah J. Harris Manoj K. Rathinaswamy John E. Burke Oncogenic mutations of PIK3CA lead to increased membrane recruitment driven by reorientation of the ABD, p85 and C-terminus Nature Communications |
| title | Oncogenic mutations of PIK3CA lead to increased membrane recruitment driven by reorientation of the ABD, p85 and C-terminus |
| title_full | Oncogenic mutations of PIK3CA lead to increased membrane recruitment driven by reorientation of the ABD, p85 and C-terminus |
| title_fullStr | Oncogenic mutations of PIK3CA lead to increased membrane recruitment driven by reorientation of the ABD, p85 and C-terminus |
| title_full_unstemmed | Oncogenic mutations of PIK3CA lead to increased membrane recruitment driven by reorientation of the ABD, p85 and C-terminus |
| title_short | Oncogenic mutations of PIK3CA lead to increased membrane recruitment driven by reorientation of the ABD, p85 and C-terminus |
| title_sort | oncogenic mutations of pik3ca lead to increased membrane recruitment driven by reorientation of the abd p85 and c terminus |
| url | https://doi.org/10.1038/s41467-023-35789-6 |
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