Reproducibility of Quantitative Brain Imaging Using a PET-Only and a Combined PET/MR System
The purpose of this study was to test the feasibility of migrating a quantitative brain imaging protocol from a positron emission tomography (PET)-only system to an integrated PET/MR system. Potential differences in both absolute radiotracer concentration as well as in the derived kinetic parameters...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-07-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fnins.2017.00396/full |
| _version_ | 1817971173913264128 |
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| author | Martin L. Lassen Otto Muzik Thomas Beyer Marcus Hacker Claes Nøhr Ladefoged Jacobo Cal-González Wolfgang Wadsak Wolfgang Wadsak Ivo Rausch Oliver Langer Oliver Langer Oliver Langer Martin Bauer |
| author_facet | Martin L. Lassen Otto Muzik Thomas Beyer Marcus Hacker Claes Nøhr Ladefoged Jacobo Cal-González Wolfgang Wadsak Wolfgang Wadsak Ivo Rausch Oliver Langer Oliver Langer Oliver Langer Martin Bauer |
| author_sort | Martin L. Lassen |
| collection | DOAJ |
| description | The purpose of this study was to test the feasibility of migrating a quantitative brain imaging protocol from a positron emission tomography (PET)-only system to an integrated PET/MR system. Potential differences in both absolute radiotracer concentration as well as in the derived kinetic parameters as a function of PET system choice have been investigated. Five healthy volunteers underwent dynamic (R)-[11C]verapamil imaging on the same day using a GE-Advance (PET-only) and a Siemens Biograph mMR system (PET/MR). PET-emission data were reconstructed using a transmission-based attenuation correction (AC) map (PET-only), whereas a standard MR-DIXON as well as a low-dose CT AC map was applied to PET/MR emission data. Kinetic modeling based on arterial blood sampling was performed using a 1-tissue-2-rate constant compartment model, yielding kinetic parameters (K1 and k2) and distribution volume (VT). Differences for parametric values obtained in the PET-only and the PET/MR systems were analyzed using a 2-way Analysis of Variance (ANOVA). Comparison of DIXON-based AC (PET/MR) with emission data derived from the PET-only system revealed average inter-system differences of −33 ± 14% (p < 0.05) for the K1 parameter and −19 ± 9% (p < 0.05) for k2. Using a CT-based AC for PET/MR resulted in slightly lower systematic differences of −16 ± 18% for K1 and −9 ± 10% for k2. The average differences in VT were −18 ± 10% (p < 0.05) for DIXON- and −8 ± 13% for CT-based AC. Significant systematic differences were observed for kinetic parameters derived from emission data obtained from PET/MR and PET-only imaging due to different standard AC methods employed. Therefore, a transfer of imaging protocols from PET-only to PET/MR systems is not straightforward without application of proper correction methods.Clinical Trial Registration:www.clinicaltrialsregister.eu, identifier 2013-001724-19 |
| first_indexed | 2024-04-13T20:44:11Z |
| format | Article |
| id | doaj.art-23c3bdef5acb4586b63307154597e8eb |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-13T20:44:11Z |
| publishDate | 2017-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-23c3bdef5acb4586b63307154597e8eb2022-12-22T02:30:45ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2017-07-011110.3389/fnins.2017.00396264677Reproducibility of Quantitative Brain Imaging Using a PET-Only and a Combined PET/MR SystemMartin L. Lassen0Otto Muzik1Thomas Beyer2Marcus Hacker3Claes Nøhr Ladefoged4Jacobo Cal-González5Wolfgang Wadsak6Wolfgang Wadsak7Ivo Rausch8Oliver Langer9Oliver Langer10Oliver Langer11Martin Bauer12Center for Medical Physics and Biomedical Engineering, Medical University of ViennaVienna, AustriaDepartment of Radiology, Detroit Medical Center, Children's Hospital of Michigan, Wayne State University School of MedicineDetroit, MI, United StatesCenter for Medical Physics and Biomedical Engineering, Medical University of ViennaVienna, AustriaDepartment of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of ViennaVienna, AustriaDepartment of Clinical Physiology, Nuclear Medicine and PETRigshospitalet, Copenhagen, DenmarkCenter for Medical Physics and Biomedical Engineering, Medical University of ViennaVienna, AustriaDepartment of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of ViennaVienna, AustriaCBmed GmbH, Center for Biomarker Research in MedicineGraz, AustriaCenter for Medical Physics and Biomedical Engineering, Medical University of ViennaVienna, AustriaDepartment of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of ViennaVienna, AustriaDepartment for Clinical Pharmacology, Medical University of ViennaVienna, AustriaHealth and Environment Department, AIT Austrian Institute of Technology GmbHSeibersdorf, AustriaDepartment for Clinical Pharmacology, Medical University of ViennaVienna, AustriaThe purpose of this study was to test the feasibility of migrating a quantitative brain imaging protocol from a positron emission tomography (PET)-only system to an integrated PET/MR system. Potential differences in both absolute radiotracer concentration as well as in the derived kinetic parameters as a function of PET system choice have been investigated. Five healthy volunteers underwent dynamic (R)-[11C]verapamil imaging on the same day using a GE-Advance (PET-only) and a Siemens Biograph mMR system (PET/MR). PET-emission data were reconstructed using a transmission-based attenuation correction (AC) map (PET-only), whereas a standard MR-DIXON as well as a low-dose CT AC map was applied to PET/MR emission data. Kinetic modeling based on arterial blood sampling was performed using a 1-tissue-2-rate constant compartment model, yielding kinetic parameters (K1 and k2) and distribution volume (VT). Differences for parametric values obtained in the PET-only and the PET/MR systems were analyzed using a 2-way Analysis of Variance (ANOVA). Comparison of DIXON-based AC (PET/MR) with emission data derived from the PET-only system revealed average inter-system differences of −33 ± 14% (p < 0.05) for the K1 parameter and −19 ± 9% (p < 0.05) for k2. Using a CT-based AC for PET/MR resulted in slightly lower systematic differences of −16 ± 18% for K1 and −9 ± 10% for k2. The average differences in VT were −18 ± 10% (p < 0.05) for DIXON- and −8 ± 13% for CT-based AC. Significant systematic differences were observed for kinetic parameters derived from emission data obtained from PET/MR and PET-only imaging due to different standard AC methods employed. Therefore, a transfer of imaging protocols from PET-only to PET/MR systems is not straightforward without application of proper correction methods.Clinical Trial Registration:www.clinicaltrialsregister.eu, identifier 2013-001724-19http://journal.frontiersin.org/article/10.3389/fnins.2017.00396/fullkinetic modelingPET/MRPETattenuation correctioninter-scan variability |
| spellingShingle | Martin L. Lassen Otto Muzik Thomas Beyer Marcus Hacker Claes Nøhr Ladefoged Jacobo Cal-González Wolfgang Wadsak Wolfgang Wadsak Ivo Rausch Oliver Langer Oliver Langer Oliver Langer Martin Bauer Reproducibility of Quantitative Brain Imaging Using a PET-Only and a Combined PET/MR System Frontiers in Neuroscience kinetic modeling PET/MR PET attenuation correction inter-scan variability |
| title | Reproducibility of Quantitative Brain Imaging Using a PET-Only and a Combined PET/MR System |
| title_full | Reproducibility of Quantitative Brain Imaging Using a PET-Only and a Combined PET/MR System |
| title_fullStr | Reproducibility of Quantitative Brain Imaging Using a PET-Only and a Combined PET/MR System |
| title_full_unstemmed | Reproducibility of Quantitative Brain Imaging Using a PET-Only and a Combined PET/MR System |
| title_short | Reproducibility of Quantitative Brain Imaging Using a PET-Only and a Combined PET/MR System |
| title_sort | reproducibility of quantitative brain imaging using a pet only and a combined pet mr system |
| topic | kinetic modeling PET/MR PET attenuation correction inter-scan variability |
| url | http://journal.frontiersin.org/article/10.3389/fnins.2017.00396/full |
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