Core-Shell Nanofibrous Scaffold Based on Polycaprolactone-Silk Fibroin Emulsion Electrospinning for Tissue Engineering Applications
The vast domain of regenerative medicine comprises complex interactions between specific cells’ extracellular matrix (ECM) towards intracellular matrix formation, its secretion, and modulation of tissue as a whole. In this domain, engineering scaffold utilizing biomaterials along with cell...
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MDPI AG
2018-08-01
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| Series: | Bioengineering |
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| Online Access: | http://www.mdpi.com/2306-5354/5/3/68 |
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| author | Trina Roy Priti Prasanna Maity Arun Prabhu Rameshbabu Bodhisatwa Das Athira John Abir Dutta Sanjoy Kumar Ghorai Santanu Chattopadhyay Santanu Dhara |
| author_facet | Trina Roy Priti Prasanna Maity Arun Prabhu Rameshbabu Bodhisatwa Das Athira John Abir Dutta Sanjoy Kumar Ghorai Santanu Chattopadhyay Santanu Dhara |
| author_sort | Trina Roy |
| collection | DOAJ |
| description | The vast domain of regenerative medicine comprises complex interactions between specific cells’ extracellular matrix (ECM) towards intracellular matrix formation, its secretion, and modulation of tissue as a whole. In this domain, engineering scaffold utilizing biomaterials along with cells towards formation of living tissues is of immense importance especially for bridging the existing gap of late; nanostructures are offering promising capability of mechano-biological response needed for tissue regeneration. Materials are selected for scaffold fabrication by considering both the mechanical integrity and bioactivity cues they offer. Herein, polycaprolactone (PCL) (biodegradable polyester) and ‘nature’s wonder’ biopolymer silk fibroin (SF) are explored in judicious combinations of emulsion electrospinning rather than conventional electrospinning of polymer blends. The water in oil (W/O) emulsions’ stability is found to be dependent upon the concentration of SF (aqueous phase) dispersed in the PCL solution (organic continuous phase). The spinnability of the emulsions is more dependent upon the viscosity of the solution, dominated by the molecular weight of PCL and its concentration than the conductivity. The nanofibers exhibited distinct core-shell structure with better cytocompatibility and cellular growth with the incorporation of the silk fibroin biopolymer. |
| first_indexed | 2024-03-12T06:42:00Z |
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| id | doaj.art-23c6e5c7cc3a4789b4b5a8c0a54485b2 |
| institution | Directory Open Access Journal |
| issn | 2306-5354 |
| language | English |
| last_indexed | 2024-03-12T06:42:00Z |
| publishDate | 2018-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj.art-23c6e5c7cc3a4789b4b5a8c0a54485b22023-09-03T00:56:06ZengMDPI AGBioengineering2306-53542018-08-01536810.3390/bioengineering5030068bioengineering5030068Core-Shell Nanofibrous Scaffold Based on Polycaprolactone-Silk Fibroin Emulsion Electrospinning for Tissue Engineering ApplicationsTrina Roy0Priti Prasanna Maity1Arun Prabhu Rameshbabu2Bodhisatwa Das3Athira John4Abir Dutta5Sanjoy Kumar Ghorai6Santanu Chattopadhyay7Santanu Dhara8Biomaterials and Tissue Engineering Laboratory, School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur 721302, IndiaBiomaterials and Tissue Engineering Laboratory, School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur 721302, IndiaBiomaterials and Tissue Engineering Laboratory, School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur 721302, IndiaBiomaterials and Tissue Engineering Laboratory, School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur 721302, IndiaCentre for Biopolymer Science and Technology (CBPST), CIPET, Kochi, Kerala 683501, IndiaAdvanced Technology Development Centre, Indian Institute of Technology Kharagpur, Kharagpur 721302, IndiaRubber Technology Centre, Indian Institute of Technology Kharagpur, Kharagpur 721302, IndiaRubber Technology Centre, Indian Institute of Technology Kharagpur, Kharagpur 721302, IndiaBiomaterials and Tissue Engineering Laboratory, School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur 721302, IndiaThe vast domain of regenerative medicine comprises complex interactions between specific cells’ extracellular matrix (ECM) towards intracellular matrix formation, its secretion, and modulation of tissue as a whole. In this domain, engineering scaffold utilizing biomaterials along with cells towards formation of living tissues is of immense importance especially for bridging the existing gap of late; nanostructures are offering promising capability of mechano-biological response needed for tissue regeneration. Materials are selected for scaffold fabrication by considering both the mechanical integrity and bioactivity cues they offer. Herein, polycaprolactone (PCL) (biodegradable polyester) and ‘nature’s wonder’ biopolymer silk fibroin (SF) are explored in judicious combinations of emulsion electrospinning rather than conventional electrospinning of polymer blends. The water in oil (W/O) emulsions’ stability is found to be dependent upon the concentration of SF (aqueous phase) dispersed in the PCL solution (organic continuous phase). The spinnability of the emulsions is more dependent upon the viscosity of the solution, dominated by the molecular weight of PCL and its concentration than the conductivity. The nanofibers exhibited distinct core-shell structure with better cytocompatibility and cellular growth with the incorporation of the silk fibroin biopolymer.http://www.mdpi.com/2306-5354/5/3/68emulsionelectrospinninghydrophilicityamphiphilictissue engineering |
| spellingShingle | Trina Roy Priti Prasanna Maity Arun Prabhu Rameshbabu Bodhisatwa Das Athira John Abir Dutta Sanjoy Kumar Ghorai Santanu Chattopadhyay Santanu Dhara Core-Shell Nanofibrous Scaffold Based on Polycaprolactone-Silk Fibroin Emulsion Electrospinning for Tissue Engineering Applications Bioengineering emulsion electrospinning hydrophilicity amphiphilic tissue engineering |
| title | Core-Shell Nanofibrous Scaffold Based on Polycaprolactone-Silk Fibroin Emulsion Electrospinning for Tissue Engineering Applications |
| title_full | Core-Shell Nanofibrous Scaffold Based on Polycaprolactone-Silk Fibroin Emulsion Electrospinning for Tissue Engineering Applications |
| title_fullStr | Core-Shell Nanofibrous Scaffold Based on Polycaprolactone-Silk Fibroin Emulsion Electrospinning for Tissue Engineering Applications |
| title_full_unstemmed | Core-Shell Nanofibrous Scaffold Based on Polycaprolactone-Silk Fibroin Emulsion Electrospinning for Tissue Engineering Applications |
| title_short | Core-Shell Nanofibrous Scaffold Based on Polycaprolactone-Silk Fibroin Emulsion Electrospinning for Tissue Engineering Applications |
| title_sort | core shell nanofibrous scaffold based on polycaprolactone silk fibroin emulsion electrospinning for tissue engineering applications |
| topic | emulsion electrospinning hydrophilicity amphiphilic tissue engineering |
| url | http://www.mdpi.com/2306-5354/5/3/68 |
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