Scaffold Hopping in Discovery of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: From CH(CN)-DABOs to CH(CN)-DAPYs

Scaffold Hopping in Discovery of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: From CH(CN)-DABOs to CH(CN)-DAPYs

Scaffold hopping is a frequently-used strategy in the development of non-nucleoside reverse transcriptase inhibitors. Herein, CH(CN)-DAPYs were designed by hopping the cyano-methylene linker of our previous published CH(CN)-DABOs onto the etravirine (ETR). Eighteen CH(CN)-DAPYs were synthesized and...

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Bibliographic Details
Main Authors: Ting-Ting Li, Christophe Pannecouque, Erik De Clercq, Chun-Lin Zhuang, Fen-Er Chen
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Molecules
Subjects:
CH(CN)-DAPYs
HIV-1
NNRTI
scaffold hopping
strucutral optimization
Online Access:https://www.mdpi.com/1420-3049/25/7/1581

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