Skin testing: A valuable screening tool to identify allergy to anesthetic agents
Anaphylaxis is a rapid-onset, life-threatening allergic reaction that needs immediate medical intervention. Typically, immunoglobulin E (IgE) mediated, these reactions necessitate skin testing for assessing drug hypersensitivity. A 31-year-old woman with cervical carcinoma, scheduled for a total hys...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Indian Journal of Allergy Asthma and Immunology |
| Subjects: | |
| Online Access: | http://www.ijaai.in/article.asp?issn=0972-6691;year=2023;volume=37;issue=2;spage=60;epage=63;aulast=Gull |
| _version_ | 1797246435407691776 |
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| author | Ayaz Gull Aariba Z Bisati Taha A Qureshi Tabasum Shafi Sheikh Imran Qazi Ashraf Roohi Rasool |
| author_facet | Ayaz Gull Aariba Z Bisati Taha A Qureshi Tabasum Shafi Sheikh Imran Qazi Ashraf Roohi Rasool |
| author_sort | Ayaz Gull |
| collection | DOAJ |
| description | Anaphylaxis is a rapid-onset, life-threatening allergic reaction that needs immediate medical intervention. Typically, immunoglobulin E (IgE) mediated, these reactions necessitate skin testing for assessing drug hypersensitivity. A 31-year-old woman with cervical carcinoma, scheduled for a total hysterectomy with bilateral salpingo-oophorectomy under general anesthesia (GA), experienced preoperative urticaria and palpitations, during a blood transfusion. Administering intravenous (IV) pheniramine, ranitidine, and dexamethasone resolved symptoms, allowing surgery under GA. However, post atracurium injection, she developed generalized urticaria and mild hypotension. IV pheniramine and hydrocortisone stabilized her, prompting surgery deferral for an allergology workup. The skin testing was performed, and all drugs tested negative. To prevent non-IgE-mediated reactions, a preoperative regimen of pheniramine 25 mg, prednisolone 50 mg, and famotidine 20 mg was recommended. Subsequently, surgery was performed under GA, using propofol and rocuronium, with the whole perioperative period remaining uneventful. This case underscores the imperative role of skin testing in elucidating perioperative drug usage amid suspected or encountered drug allergies. |
| first_indexed | 2024-04-24T19:42:45Z |
| format | Article |
| id | doaj.art-23c83418ad234ef49ccab96303da78a8 |
| institution | Directory Open Access Journal |
| issn | 0972-6691 |
| language | English |
| last_indexed | 2024-04-24T19:42:45Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Allergy Asthma and Immunology |
| spelling | doaj.art-23c83418ad234ef49ccab96303da78a82024-03-25T10:27:46ZengWolters Kluwer Medknow PublicationsIndian Journal of Allergy Asthma and Immunology0972-66912023-01-01372606310.4103/ijaai.ijaai_36_23Skin testing: A valuable screening tool to identify allergy to anesthetic agentsAyaz GullAariba Z BisatiTaha A QureshiTabasum ShafiSheikh ImranQazi AshrafRoohi RasoolAnaphylaxis is a rapid-onset, life-threatening allergic reaction that needs immediate medical intervention. Typically, immunoglobulin E (IgE) mediated, these reactions necessitate skin testing for assessing drug hypersensitivity. A 31-year-old woman with cervical carcinoma, scheduled for a total hysterectomy with bilateral salpingo-oophorectomy under general anesthesia (GA), experienced preoperative urticaria and palpitations, during a blood transfusion. Administering intravenous (IV) pheniramine, ranitidine, and dexamethasone resolved symptoms, allowing surgery under GA. However, post atracurium injection, she developed generalized urticaria and mild hypotension. IV pheniramine and hydrocortisone stabilized her, prompting surgery deferral for an allergology workup. The skin testing was performed, and all drugs tested negative. To prevent non-IgE-mediated reactions, a preoperative regimen of pheniramine 25 mg, prednisolone 50 mg, and famotidine 20 mg was recommended. Subsequently, surgery was performed under GA, using propofol and rocuronium, with the whole perioperative period remaining uneventful. This case underscores the imperative role of skin testing in elucidating perioperative drug usage amid suspected or encountered drug allergies.http://www.ijaai.in/article.asp?issn=0972-6691;year=2023;volume=37;issue=2;spage=60;epage=63;aulast=Gullanesthetic agentsdrug allergyskin testing |
| spellingShingle | Ayaz Gull Aariba Z Bisati Taha A Qureshi Tabasum Shafi Sheikh Imran Qazi Ashraf Roohi Rasool Skin testing: A valuable screening tool to identify allergy to anesthetic agents Indian Journal of Allergy Asthma and Immunology anesthetic agents drug allergy skin testing |
| title | Skin testing: A valuable screening tool to identify allergy to anesthetic agents |
| title_full | Skin testing: A valuable screening tool to identify allergy to anesthetic agents |
| title_fullStr | Skin testing: A valuable screening tool to identify allergy to anesthetic agents |
| title_full_unstemmed | Skin testing: A valuable screening tool to identify allergy to anesthetic agents |
| title_short | Skin testing: A valuable screening tool to identify allergy to anesthetic agents |
| title_sort | skin testing a valuable screening tool to identify allergy to anesthetic agents |
| topic | anesthetic agents drug allergy skin testing |
| url | http://www.ijaai.in/article.asp?issn=0972-6691;year=2023;volume=37;issue=2;spage=60;epage=63;aulast=Gull |
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