Cell death in the pathogenesis of immune-mediated diseases
Cell death is a ubiquitous process whose immunological consequences can influence the course of infectious, autoimmune and inflammatory diseases. While cell death has long been dichotomised in terms of apoptosis and necrosis, other forms of death can occur and they vary in their capacity to st...
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| Format: | Article |
| Language: | English |
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SMW supporting association (Trägerverein Swiss Medical Weekly SMW)
2011-08-01
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| Series: | Swiss Medical Weekly |
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| Online Access: | https://www.smw.ch/index.php/smw/article/view/1341 |
| _version_ | 1811194071990927360 |
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| author | D Pisetsky |
| author_facet | D Pisetsky |
| author_sort | D Pisetsky |
| collection | DOAJ |
| description |
Cell death is a ubiquitous process whose immunological consequences can influence the course of infectious, autoimmune and inflammatory diseases. While cell death has long been dichotomised in terms of apoptosis and necrosis, other forms of death can occur and they vary in their capacity to stimulate as well as inhibit inflammation. The pro-inflammatory activity of dead cells results from a wide variety of intracellular molecules that are released as cell permeability increases during death. These molecules have been termed as DAMPs (damage associated molecular patterns) or alarmins. Among these DAMPs, HMGB1, a non-histone nuclear protein, serves as the prototype. Although HMGB1 was originally thought to act alone as a cytokine, recent studies suggest that its immunological effects result from complexes of HMGB1 with either other DAMPs or with PAMPs (pathogen associated molecular patterns). Studies on the role of HMGB1 in pathogenesis suggest that the formation of extracellular complexes is an important mechanism for generating pro-inflammatory signals during cell death and therefore could be a potential target of new therapy.
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| first_indexed | 2024-04-12T00:19:56Z |
| format | Article |
| id | doaj.art-23c89f68e0084f46a071197e1af7eadf |
| institution | Directory Open Access Journal |
| issn | 1424-3997 |
| language | English |
| last_indexed | 2024-04-12T00:19:56Z |
| publishDate | 2011-08-01 |
| publisher | SMW supporting association (Trägerverein Swiss Medical Weekly SMW) |
| record_format | Article |
| series | Swiss Medical Weekly |
| spelling | doaj.art-23c89f68e0084f46a071197e1af7eadf2022-12-22T03:55:44ZengSMW supporting association (Trägerverein Swiss Medical Weekly SMW)Swiss Medical Weekly1424-39972011-08-01141353610.4414/smw.2011.13256Cell death in the pathogenesis of immune-mediated diseasesD Pisetsky Cell death is a ubiquitous process whose immunological consequences can influence the course of infectious, autoimmune and inflammatory diseases. While cell death has long been dichotomised in terms of apoptosis and necrosis, other forms of death can occur and they vary in their capacity to stimulate as well as inhibit inflammation. The pro-inflammatory activity of dead cells results from a wide variety of intracellular molecules that are released as cell permeability increases during death. These molecules have been termed as DAMPs (damage associated molecular patterns) or alarmins. Among these DAMPs, HMGB1, a non-histone nuclear protein, serves as the prototype. Although HMGB1 was originally thought to act alone as a cytokine, recent studies suggest that its immunological effects result from complexes of HMGB1 with either other DAMPs or with PAMPs (pathogen associated molecular patterns). Studies on the role of HMGB1 in pathogenesis suggest that the formation of extracellular complexes is an important mechanism for generating pro-inflammatory signals during cell death and therefore could be a potential target of new therapy. https://www.smw.ch/index.php/smw/article/view/1341alarminapoptosisHMGB1inflammationnecrosis |
| spellingShingle | D Pisetsky Cell death in the pathogenesis of immune-mediated diseases Swiss Medical Weekly alarmin apoptosis HMGB1 inflammation necrosis |
| title | Cell death in the pathogenesis of immune-mediated diseases |
| title_full | Cell death in the pathogenesis of immune-mediated diseases |
| title_fullStr | Cell death in the pathogenesis of immune-mediated diseases |
| title_full_unstemmed | Cell death in the pathogenesis of immune-mediated diseases |
| title_short | Cell death in the pathogenesis of immune-mediated diseases |
| title_sort | cell death in the pathogenesis of immune mediated diseases |
| topic | alarmin apoptosis HMGB1 inflammation necrosis |
| url | https://www.smw.ch/index.php/smw/article/view/1341 |
| work_keys_str_mv | AT dpisetsky celldeathinthepathogenesisofimmunemediateddiseases |