Biomechanical Properties of the Aortic Wall: Changes during Vascular Calcification
Medial vascular calcification (MAC) is characterized by the deposition of hydroxyapatite (HAP) in the medial layer of the vessel wall, leading to disruption of vessel integrity and vascular stiffness. Because currently no direct therapeutic interventions for MAC are available, studying the MAC patho...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/1/211 |
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| author | Jinwen Zhou Manasa Reddy Gummi Anna Greco Milen Babic Jaqueline Herrmann Farid I. Kandil Markus van der Giet Markus Tölle Mirjam Schuchardt |
| author_facet | Jinwen Zhou Manasa Reddy Gummi Anna Greco Milen Babic Jaqueline Herrmann Farid I. Kandil Markus van der Giet Markus Tölle Mirjam Schuchardt |
| author_sort | Jinwen Zhou |
| collection | DOAJ |
| description | Medial vascular calcification (MAC) is characterized by the deposition of hydroxyapatite (HAP) in the medial layer of the vessel wall, leading to disruption of vessel integrity and vascular stiffness. Because currently no direct therapeutic interventions for MAC are available, studying the MAC pathogenesis is of high research interest. Several methods exist to measure and describe the pathophysiological processes in the vessel wall, such as histological staining and gene expression. However, no method describing the physiological properties of the arterial wall is currently available. This study aims to close that gap and validate a method to measure the biomechanical properties of the arterial wall during vascular calcification. Therefore, a stress–stretch curve is monitored using small-vessel-myography upon ex vivo calcification of rat aortic tissue. The measurement of biomechanical properties could help to gain further insights into vessel integrity during calcification progression. |
| first_indexed | 2024-03-09T13:27:58Z |
| format | Article |
| id | doaj.art-23c998b3de184197bdb2bada514345c1 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T13:27:58Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-23c998b3de184197bdb2bada514345c12023-11-30T21:21:06ZengMDPI AGBiomedicines2227-90592023-01-0111121110.3390/biomedicines11010211Biomechanical Properties of the Aortic Wall: Changes during Vascular CalcificationJinwen Zhou0Manasa Reddy Gummi1Anna Greco2Milen Babic3Jaqueline Herrmann4Farid I. Kandil5Markus van der Giet6Markus Tölle7Mirjam Schuchardt8Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Department of Nephrology and Medical Intensive Care, Hindenburgdamm 30, 12203 Berlin, GermanyCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Department of Nephrology and Medical Intensive Care, Hindenburgdamm 30, 12203 Berlin, GermanyCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Department of Nephrology and Medical Intensive Care, Hindenburgdamm 30, 12203 Berlin, GermanyCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Department of Nephrology and Medical Intensive Care, Hindenburgdamm 30, 12203 Berlin, GermanyCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Department of Nephrology and Medical Intensive Care, Hindenburgdamm 30, 12203 Berlin, GermanyCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Institute of Social Medicine, Epidemiology and Health Economics, Luisenstraße 57, 10117 Berlin, GermanyCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Department of Nephrology and Medical Intensive Care, Hindenburgdamm 30, 12203 Berlin, GermanyCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Department of Nephrology and Medical Intensive Care, Hindenburgdamm 30, 12203 Berlin, GermanyCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Department of Nephrology and Medical Intensive Care, Hindenburgdamm 30, 12203 Berlin, GermanyMedial vascular calcification (MAC) is characterized by the deposition of hydroxyapatite (HAP) in the medial layer of the vessel wall, leading to disruption of vessel integrity and vascular stiffness. Because currently no direct therapeutic interventions for MAC are available, studying the MAC pathogenesis is of high research interest. Several methods exist to measure and describe the pathophysiological processes in the vessel wall, such as histological staining and gene expression. However, no method describing the physiological properties of the arterial wall is currently available. This study aims to close that gap and validate a method to measure the biomechanical properties of the arterial wall during vascular calcification. Therefore, a stress–stretch curve is monitored using small-vessel-myography upon ex vivo calcification of rat aortic tissue. The measurement of biomechanical properties could help to gain further insights into vessel integrity during calcification progression.https://www.mdpi.com/2227-9059/11/1/211aortabiomechanical propertiescalcificationpassive responsestressstretch |
| spellingShingle | Jinwen Zhou Manasa Reddy Gummi Anna Greco Milen Babic Jaqueline Herrmann Farid I. Kandil Markus van der Giet Markus Tölle Mirjam Schuchardt Biomechanical Properties of the Aortic Wall: Changes during Vascular Calcification Biomedicines aorta biomechanical properties calcification passive response stress stretch |
| title | Biomechanical Properties of the Aortic Wall: Changes during Vascular Calcification |
| title_full | Biomechanical Properties of the Aortic Wall: Changes during Vascular Calcification |
| title_fullStr | Biomechanical Properties of the Aortic Wall: Changes during Vascular Calcification |
| title_full_unstemmed | Biomechanical Properties of the Aortic Wall: Changes during Vascular Calcification |
| title_short | Biomechanical Properties of the Aortic Wall: Changes during Vascular Calcification |
| title_sort | biomechanical properties of the aortic wall changes during vascular calcification |
| topic | aorta biomechanical properties calcification passive response stress stretch |
| url | https://www.mdpi.com/2227-9059/11/1/211 |
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