Molecular Epidemiology of Sapovirus in Children Living in the Northwest Amazon Region
Sapovirus is an important etiological agent of acute gastroenteritis (AGE), mainly in children under 5 years old living in lower-income communities. Eighteen identified sapovirus genotypes have been observed to infect humans. The aim of this study was to identify sapovirus genotypes circulating in t...
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MDPI AG
2021-07-01
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| author | Marcia Terezinha Baroni de Moraes Gabriel Azevedo Alves Leitão Alberto Ignácio Olivares Olivares Maria da Penha Trindade Pinheiro Xavier Romanul de Souza Bispo Sumit Sharma José Paulo Gagliardi Leite Lennart Svensson Johan Nordgren |
| author_facet | Marcia Terezinha Baroni de Moraes Gabriel Azevedo Alves Leitão Alberto Ignácio Olivares Olivares Maria da Penha Trindade Pinheiro Xavier Romanul de Souza Bispo Sumit Sharma José Paulo Gagliardi Leite Lennart Svensson Johan Nordgren |
| author_sort | Marcia Terezinha Baroni de Moraes |
| collection | DOAJ |
| description | Sapovirus is an important etiological agent of acute gastroenteritis (AGE), mainly in children under 5 years old living in lower-income communities. Eighteen identified sapovirus genotypes have been observed to infect humans. The aim of this study was to identify sapovirus genotypes circulating in the Amazon region. Twenty-eight samples were successfully genotyped using partial sequencing of the capsid gene. The genotypes identified were GI.1 (<i>n</i> = 3), GI.2 (<i>n</i> = 7), GII.1 (<i>n</i> = 1), GII.2 (<i>n</i> = 1), GII.3 (<i>n</i> = 5), GII.5 (<i>n</i> = 1), and GIV.1 (<i>n</i> = 10). The GIV genotype was the most detected genotype (35.7%, 10/28). The phylogenetic analysis identified sapovirus genotypes that had no similarity with other strains reported from Brazil, indicating that these genotypes may have entered the Amazon region via intense tourism in the Amazon rainforest. No association between histo-blood group antigen expression and sapovirus infection was observed. |
| first_indexed | 2024-03-10T08:29:57Z |
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| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-10T08:29:57Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-23c9e3e03b0c43bc93c3be36017fee2b2023-11-22T09:08:43ZengMDPI AGPathogens2076-08172021-07-0110896510.3390/pathogens10080965Molecular Epidemiology of Sapovirus in Children Living in the Northwest Amazon RegionMarcia Terezinha Baroni de Moraes0Gabriel Azevedo Alves Leitão1Alberto Ignácio Olivares Olivares2Maria da Penha Trindade Pinheiro Xavier3Romanul de Souza Bispo4Sumit Sharma5José Paulo Gagliardi Leite6Lennart Svensson7Johan Nordgren8Laboratory of Comparative and Environmental Virology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro 21040-360, RJ, BrazilLaboratory of Comparative and Environmental Virology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro 21040-360, RJ, BrazilSecretaria Estadual de Saúde de Roraima, SESAU/RR, Boa Vista 69310-043, RR, BrazilLaboratory of Comparative and Environmental Virology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro 21040-360, RJ, BrazilResearch Center Roraima Health Observatory (ObservaRR), Federal University of Roraima, Boa Vista 69310-000, RR, BrazilDepartment of Biomedical and Clinical Sciences, Division of Molecular Medicine and Virology, Linköping University, 581 85 Linköping, SwedenLaboratory of Comparative and Environmental Virology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro 21040-360, RJ, BrazilDepartment of Biomedical and Clinical Sciences, Division of Molecular Medicine and Virology, Linköping University, 581 85 Linköping, SwedenDepartment of Biomedical and Clinical Sciences, Division of Molecular Medicine and Virology, Linköping University, 581 85 Linköping, SwedenSapovirus is an important etiological agent of acute gastroenteritis (AGE), mainly in children under 5 years old living in lower-income communities. Eighteen identified sapovirus genotypes have been observed to infect humans. The aim of this study was to identify sapovirus genotypes circulating in the Amazon region. Twenty-eight samples were successfully genotyped using partial sequencing of the capsid gene. The genotypes identified were GI.1 (<i>n</i> = 3), GI.2 (<i>n</i> = 7), GII.1 (<i>n</i> = 1), GII.2 (<i>n</i> = 1), GII.3 (<i>n</i> = 5), GII.5 (<i>n</i> = 1), and GIV.1 (<i>n</i> = 10). The GIV genotype was the most detected genotype (35.7%, 10/28). The phylogenetic analysis identified sapovirus genotypes that had no similarity with other strains reported from Brazil, indicating that these genotypes may have entered the Amazon region via intense tourism in the Amazon rainforest. No association between histo-blood group antigen expression and sapovirus infection was observed.https://www.mdpi.com/2076-0817/10/8/965Sapovirushisto-blood group antigenAmazon region |
| spellingShingle | Marcia Terezinha Baroni de Moraes Gabriel Azevedo Alves Leitão Alberto Ignácio Olivares Olivares Maria da Penha Trindade Pinheiro Xavier Romanul de Souza Bispo Sumit Sharma José Paulo Gagliardi Leite Lennart Svensson Johan Nordgren Molecular Epidemiology of Sapovirus in Children Living in the Northwest Amazon Region Pathogens Sapovirus histo-blood group antigen Amazon region |
| title | Molecular Epidemiology of Sapovirus in Children Living in the Northwest Amazon Region |
| title_full | Molecular Epidemiology of Sapovirus in Children Living in the Northwest Amazon Region |
| title_fullStr | Molecular Epidemiology of Sapovirus in Children Living in the Northwest Amazon Region |
| title_full_unstemmed | Molecular Epidemiology of Sapovirus in Children Living in the Northwest Amazon Region |
| title_short | Molecular Epidemiology of Sapovirus in Children Living in the Northwest Amazon Region |
| title_sort | molecular epidemiology of sapovirus in children living in the northwest amazon region |
| topic | Sapovirus histo-blood group antigen Amazon region |
| url | https://www.mdpi.com/2076-0817/10/8/965 |
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