Cryo-EM structure of the mechanically activated ion channel OSCA1.2

Cryo-EM structure of the mechanically activated ion channel OSCA1.2

Mechanically activated ion channels underlie touch, hearing, shear-stress sensing, and response to turgor pressure. OSCA/TMEM63s are a newly-identified family of eukaryotic mechanically activated ion channels opened by membrane tension. The structural underpinnings of OSCA/TMEM63 function are not ex...

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Bibliographic Details
Main Authors: Sebastian Jojoa-Cruz, Kei Saotome, Swetha E Murthy, Che Chun Alex Tsui, Mark SP Sansom, Ardem Patapoutian, Andrew B Ward
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-11-01
Series:eLife
Subjects:
ion channel
electron microscopy
mechanotransduction
Online Access:https://elifesciences.org/articles/41845

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