| Summary: | Objective To compare the quality and safety of platelet-rich plasma (PRP) by blood bag and monopheresis. Methods A retrospective analysis was performed on 66 patients treated with autologous PRP therapy in the blood transfusion department of First Affiliated Hospital of Army Medical University from July 2019 to August 2021. According to preparation procedure, they were divided into blood bag group (n=30, with 47 times of preparation) and monopheresis group (n=36, with 36 times of preparation). The counts of erythrocytes, leukocytes and platelets and product multiples in the PRP products were detected and compared between the 2 groups. Adverse reactions were recorded and safety was evaluated. Results The preparation time, product volume, product concentration and product multiple were significantly better in the monopheresis group than the blood bag group (P < 0.01). The amount of mixed red blood cells was statistically less in the blood bag group than the apheresis group (P < 0.01). There was no notable difference in the amount of mixed white blood cells between the 2 groups. No adverse reactions were seen in both groups. Conclusion The monopheresis PRP products have higher platelets concentration than those by blood bag and need shorter time of procedure group. Therefore, monopheresis is recommended as first choice and blood bag as the alternative.
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