Hemoporfin-Mediated Photodynamic Therapy for Port-Wine Stains on Extremities
Abstract Introduction Pulsed dye laser (PDL) is currently considered to be the first-line treatment for port-wine stains (PWSs) on the extremities despite its less than satisfactory therapeutic efficacy. Hemoporfin-mediated photodynamic therapy (HMME-PDT) is a vascular-targeted therapy that has rare...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Adis, Springer Healthcare
2023-07-01
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| Series: | Dermatology and Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s13555-023-00970-8 |
| _version_ | 1797769621177106432 |
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| author | Jie Kang Jing-jing Liu Yu-hong Fang Yan-yan Lin Wei Gong Huai-yu Wang Li-hang Lin Xue-min Xiao |
| author_facet | Jie Kang Jing-jing Liu Yu-hong Fang Yan-yan Lin Wei Gong Huai-yu Wang Li-hang Lin Xue-min Xiao |
| author_sort | Jie Kang |
| collection | DOAJ |
| description | Abstract Introduction Pulsed dye laser (PDL) is currently considered to be the first-line treatment for port-wine stains (PWSs) on the extremities despite its less than satisfactory therapeutic efficacy. Hemoporfin-mediated photodynamic therapy (HMME-PDT) is a vascular-targeted therapy that has rarely been used to treat PWSs on the extremities. Here, we evaluate the clinical efficacy and safety of HMME-PDT for the treatment of PWSs on the extremities. Methods Clinical data and dermoscopic images of PWSs on the extremities were obtained from 65 patients who underwent HMME-PDT between February 2019 and December 2022. The clinical efficacy of HMME-PDT was analyzed by comparing the pre- and post-treatment images. The safety of HMME-PDT was evaluated through observation during the treatment period and post-treatment follow-up. Results The efficacy rate of a single HMME-PDT session was 63.0% and that of two and three to six sessions was 86.7% and 91.3%, respectively. A positive correlation was found between therapeutic efficacy and the number of HMME-PDT sessions. The therapeutic efficacy of HMME-PDT was better on the proximal extremities than on other parts of the extremities (P = 0.038), and the efficacy of treating PWSs in each site was relatively improved with an increase of treatment time. The clinical efficacy of HMME-PDT differed across four PWS vascular patterns identified by dermoscopy (P = 0.019). However, there was no statistical difference in the therapeutic efficacy based on age, sex, type of PWS, and treatment history (P > 0.05), which may be partly attributed to the relatively small sample size or poor cooperation of infant patients. No obvious adverse reactions were observed during the follow-up period. Conclusions HMME-PDT is a very safe and effective treatment for PWSs on the extremities. Multiple HMME-PDT treatments, lesions located in proximal limbs, and PWSs with type I and IV vascular patterns under dermoscopy were associated with higher efficacy of HMME-PDT. Dermoscopy may help predict the clinical efficacy of HMME-PDT. Trial Registration No. 2020KJT085. |
| first_indexed | 2024-03-12T21:11:39Z |
| format | Article |
| id | doaj.art-23cc8124a86640dab059fbb7873951ab |
| institution | Directory Open Access Journal |
| issn | 2193-8210 2190-9172 |
| language | English |
| last_indexed | 2024-03-12T21:11:39Z |
| publishDate | 2023-07-01 |
| publisher | Adis, Springer Healthcare |
| record_format | Article |
| series | Dermatology and Therapy |
| spelling | doaj.art-23cc8124a86640dab059fbb7873951ab2023-07-30T11:08:22ZengAdis, Springer HealthcareDermatology and Therapy2193-82102190-91722023-07-011381857187110.1007/s13555-023-00970-8Hemoporfin-Mediated Photodynamic Therapy for Port-Wine Stains on ExtremitiesJie Kang0Jing-jing Liu1Yu-hong Fang2Yan-yan Lin3Wei Gong4Huai-yu Wang5Li-hang Lin6Xue-min Xiao7Department of Dermatology, The Union Hospital–Fujian Medical UniversityDepartment of Dermatology, The Union Hospital–Fujian Medical UniversityKey Laboratory of OptoElectronic Science and Technology for Medicine of the Ministry of Education, College of Photonic and Electronic Engineering, Fujian Normal UniversityDepartment of Dermatology, The Union Hospital–Fujian Medical UniversityKey Laboratory of OptoElectronic Science and Technology for Medicine of the Ministry of Education, College of Photonic and Electronic Engineering, Fujian Normal UniversityDepartment of Dermatology, The Union Hospital–Fujian Medical UniversityDepartment of Dermatology, The Union Hospital–Fujian Medical UniversityDepartment of Dermatology, The Union Hospital–Fujian Medical UniversityAbstract Introduction Pulsed dye laser (PDL) is currently considered to be the first-line treatment for port-wine stains (PWSs) on the extremities despite its less than satisfactory therapeutic efficacy. Hemoporfin-mediated photodynamic therapy (HMME-PDT) is a vascular-targeted therapy that has rarely been used to treat PWSs on the extremities. Here, we evaluate the clinical efficacy and safety of HMME-PDT for the treatment of PWSs on the extremities. Methods Clinical data and dermoscopic images of PWSs on the extremities were obtained from 65 patients who underwent HMME-PDT between February 2019 and December 2022. The clinical efficacy of HMME-PDT was analyzed by comparing the pre- and post-treatment images. The safety of HMME-PDT was evaluated through observation during the treatment period and post-treatment follow-up. Results The efficacy rate of a single HMME-PDT session was 63.0% and that of two and three to six sessions was 86.7% and 91.3%, respectively. A positive correlation was found between therapeutic efficacy and the number of HMME-PDT sessions. The therapeutic efficacy of HMME-PDT was better on the proximal extremities than on other parts of the extremities (P = 0.038), and the efficacy of treating PWSs in each site was relatively improved with an increase of treatment time. The clinical efficacy of HMME-PDT differed across four PWS vascular patterns identified by dermoscopy (P = 0.019). However, there was no statistical difference in the therapeutic efficacy based on age, sex, type of PWS, and treatment history (P > 0.05), which may be partly attributed to the relatively small sample size or poor cooperation of infant patients. No obvious adverse reactions were observed during the follow-up period. Conclusions HMME-PDT is a very safe and effective treatment for PWSs on the extremities. Multiple HMME-PDT treatments, lesions located in proximal limbs, and PWSs with type I and IV vascular patterns under dermoscopy were associated with higher efficacy of HMME-PDT. Dermoscopy may help predict the clinical efficacy of HMME-PDT. Trial Registration No. 2020KJT085.https://doi.org/10.1007/s13555-023-00970-8DermoscopyEfficacy analysisExtremitiesHematoporphyrin monomethyl etherPhotodynamic therapyPort-wine stains |
| spellingShingle | Jie Kang Jing-jing Liu Yu-hong Fang Yan-yan Lin Wei Gong Huai-yu Wang Li-hang Lin Xue-min Xiao Hemoporfin-Mediated Photodynamic Therapy for Port-Wine Stains on Extremities Dermatology and Therapy Dermoscopy Efficacy analysis Extremities Hematoporphyrin monomethyl ether Photodynamic therapy Port-wine stains |
| title | Hemoporfin-Mediated Photodynamic Therapy for Port-Wine Stains on Extremities |
| title_full | Hemoporfin-Mediated Photodynamic Therapy for Port-Wine Stains on Extremities |
| title_fullStr | Hemoporfin-Mediated Photodynamic Therapy for Port-Wine Stains on Extremities |
| title_full_unstemmed | Hemoporfin-Mediated Photodynamic Therapy for Port-Wine Stains on Extremities |
| title_short | Hemoporfin-Mediated Photodynamic Therapy for Port-Wine Stains on Extremities |
| title_sort | hemoporfin mediated photodynamic therapy for port wine stains on extremities |
| topic | Dermoscopy Efficacy analysis Extremities Hematoporphyrin monomethyl ether Photodynamic therapy Port-wine stains |
| url | https://doi.org/10.1007/s13555-023-00970-8 |
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