Targeting DCLK1 attenuates tumor stemness and evokes antitumor immunity in triple-negative breast cancer by inhibiting IL-6/STAT3 signaling

Targeting DCLK1 attenuates tumor stemness and evokes antitumor immunity in triple-negative breast cancer by inhibiting IL-6/STAT3 signaling

Abstract Triple-negative breast cancer (TNBC) exhibits the poorest outcomes among breast cancer subtypes due to the high heterogeneity and a lasting scarcity of effectual treatments. Targeted therapies based on molecular subtypes of TNBC are critical step toward tailoring treatments to improve clini...

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Bibliographic Details
Main Authors:	Heshu Liu, Rui Yan, Zeru Xiao, Xuying Huang, Jiannan Yao, Jian Liu, Guangyu An, Yang Ge
Format:	Article
Language:	English
Published:	BMC 2023-04-01
Series:	Breast Cancer Research
Subjects:	Triple-negative breast cancer DCLK1 CSCs IL-6/STAT3 signaling The mesenchymal-like subtype
Online Access:	https://doi.org/10.1186/s13058-023-01642-3

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