Targeting DCLK1 attenuates tumor stemness and evokes antitumor immunity in triple-negative breast cancer by inhibiting IL-6/STAT3 signaling

Targeting DCLK1 attenuates tumor stemness and evokes antitumor immunity in triple-negative breast cancer by inhibiting IL-6/STAT3 signaling

Abstract Triple-negative breast cancer (TNBC) exhibits the poorest outcomes among breast cancer subtypes due to the high heterogeneity and a lasting scarcity of effectual treatments. Targeted therapies based on molecular subtypes of TNBC are critical step toward tailoring treatments to improve clini...

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Bibliographic Details
Main Authors: Heshu Liu, Rui Yan, Zeru Xiao, Xuying Huang, Jiannan Yao, Jian Liu, Guangyu An, Yang Ge
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Breast Cancer Research
Subjects:
Triple-negative breast cancer
DCLK1
CSCs
IL-6/STAT3 signaling
The mesenchymal-like subtype
Online Access:https://doi.org/10.1186/s13058-023-01642-3

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