Sphingomyelin-Rich Lipid Extract Collar for Canine Atopic Dermatitis
The management of canine atopic dermatitis (CAD) is complex, and it needs to be multimodal, combining topical and systemic therapies. Given that the currently available options are not always totally effective and might have some associated adverse effects, novel alternatives are needed. For this re...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Veterinary Sciences |
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| Online Access: | https://www.mdpi.com/2306-7381/10/6/389 |
| _version_ | 1797592343062249472 |
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| author | Sergi Segarra David Sanmiguel Eliseo Zuriaga Sophie Leclerc Jesús Cabañas Estelle Seigneuric Aurélie Miquel Ana Vázquez Lluís Ferrer |
| author_facet | Sergi Segarra David Sanmiguel Eliseo Zuriaga Sophie Leclerc Jesús Cabañas Estelle Seigneuric Aurélie Miquel Ana Vázquez Lluís Ferrer |
| author_sort | Sergi Segarra |
| collection | DOAJ |
| description | The management of canine atopic dermatitis (CAD) is complex, and it needs to be multimodal, combining topical and systemic therapies. Given that the currently available options are not always totally effective and might have some associated adverse effects, novel alternatives are needed. For this reason, a new collar for CAD was developed with 2.5% of a sphingomyelin-rich lipid extract (LE) with proven benefits for skin health. The release of the active ingredient when incorporated into the collar was tested in vitro, showing an adequate kinetic profile. Then, the efficacy and safety of the collar were assessed in 12 client-owned dogs with CAD in a pilot study. After eight weeks, the dogs experienced significant clinical improvements on the Canine Atopic Dermatitis Extent and Severity Index (CADESI)-4, Pruritus Index for Canine Atopic Dermatitis (PCAD) and Pruritus Visual Analogue Scale (PVAS) scores, without any adverse effects. Additionally, further in vitro studies were performed, indicating that this LE collar should be compatible with antiparasitic collars (with deltamethrin or imidacloprid/flumethrin) if worn simultaneously. Given the observed benefits of this LE collar, combining it with other CAD therapies could potentially allow for drug sparing, reduction in adverse effects, enhanced owner compliance, and reduced treatment costs. |
| first_indexed | 2024-03-11T01:50:45Z |
| format | Article |
| id | doaj.art-23cd2cfd37754bb5a28cc0d13f6cde51 |
| institution | Directory Open Access Journal |
| issn | 2306-7381 |
| language | English |
| last_indexed | 2024-03-11T01:50:45Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Veterinary Sciences |
| spelling | doaj.art-23cd2cfd37754bb5a28cc0d13f6cde512023-11-18T13:00:12ZengMDPI AGVeterinary Sciences2306-73812023-06-0110638910.3390/vetsci10060389Sphingomyelin-Rich Lipid Extract Collar for Canine Atopic DermatitisSergi Segarra0David Sanmiguel1Eliseo Zuriaga2Sophie Leclerc3Jesús Cabañas4Estelle Seigneuric5Aurélie Miquel6Ana Vázquez7Lluís Ferrer8R&D Bioiberica S.A.U., Avinguda dels Països Catalans, 34, 08950 Esplugues de Llobregat, SpainClínica Veterinaria Wecan De Carreres, Avinguda Mutxamel, 1, Local 2, 03550 Sant Joan d’Alacant, SpainHospital Veterinario Global, Carrer Laminacio, 18, 46520 Port de Sagunt, SpainAB7 Santé, BP 9 Les Monges, 31450 Deyme, FranceR&D Bioiberica S.A.U., Avinguda dels Països Catalans, 34, 08950 Esplugues de Llobregat, SpainAB7 Santé, BP 9 Les Monges, 31450 Deyme, FranceAB7 Santé, BP 9 Les Monges, 31450 Deyme, FranceServei d’Estadística Aplicada, Facultat de Ciències, Universitat Autònoma de Barcelona, C5b/111, Edifici C, 08193 Cerdanyola del Vallès, SpainDepartament de Medicina i Cirurgia Animals, S/N, Campus Universitat Autònoma de Barcelona, 08193 Cerdanyola del Vallès, SpainThe management of canine atopic dermatitis (CAD) is complex, and it needs to be multimodal, combining topical and systemic therapies. Given that the currently available options are not always totally effective and might have some associated adverse effects, novel alternatives are needed. For this reason, a new collar for CAD was developed with 2.5% of a sphingomyelin-rich lipid extract (LE) with proven benefits for skin health. The release of the active ingredient when incorporated into the collar was tested in vitro, showing an adequate kinetic profile. Then, the efficacy and safety of the collar were assessed in 12 client-owned dogs with CAD in a pilot study. After eight weeks, the dogs experienced significant clinical improvements on the Canine Atopic Dermatitis Extent and Severity Index (CADESI)-4, Pruritus Index for Canine Atopic Dermatitis (PCAD) and Pruritus Visual Analogue Scale (PVAS) scores, without any adverse effects. Additionally, further in vitro studies were performed, indicating that this LE collar should be compatible with antiparasitic collars (with deltamethrin or imidacloprid/flumethrin) if worn simultaneously. Given the observed benefits of this LE collar, combining it with other CAD therapies could potentially allow for drug sparing, reduction in adverse effects, enhanced owner compliance, and reduced treatment costs.https://www.mdpi.com/2306-7381/10/6/389atopic dermatitissphingolipidssphingomyelincollarpruritusatopic disease |
| spellingShingle | Sergi Segarra David Sanmiguel Eliseo Zuriaga Sophie Leclerc Jesús Cabañas Estelle Seigneuric Aurélie Miquel Ana Vázquez Lluís Ferrer Sphingomyelin-Rich Lipid Extract Collar for Canine Atopic Dermatitis Veterinary Sciences atopic dermatitis sphingolipids sphingomyelin collar pruritus atopic disease |
| title | Sphingomyelin-Rich Lipid Extract Collar for Canine Atopic Dermatitis |
| title_full | Sphingomyelin-Rich Lipid Extract Collar for Canine Atopic Dermatitis |
| title_fullStr | Sphingomyelin-Rich Lipid Extract Collar for Canine Atopic Dermatitis |
| title_full_unstemmed | Sphingomyelin-Rich Lipid Extract Collar for Canine Atopic Dermatitis |
| title_short | Sphingomyelin-Rich Lipid Extract Collar for Canine Atopic Dermatitis |
| title_sort | sphingomyelin rich lipid extract collar for canine atopic dermatitis |
| topic | atopic dermatitis sphingolipids sphingomyelin collar pruritus atopic disease |
| url | https://www.mdpi.com/2306-7381/10/6/389 |
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