Etiological factors of short stature in children and adolescents: experience at a tertiary care hospital in Egypt
Background: Accurate anthropometric measurements and critical analysis of growth data allow the clinician to promptly recognize children with short stature. The aim of this study was to determine the frequency of etiological factors causing short stature among children referred to the pediatric endo...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2017-05-01
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| Series: | Therapeutic Advances in Endocrinology and Metabolism |
| Online Access: | https://doi.org/10.1177/2042018817707464 |
| _version_ | 1819210363038597120 |
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| author | Almontaser Hussein Hekma Farghaly Eman Askar Kotb Metwalley Khaled Saad Asmaa Zahran Hisham A. Othman |
| author_facet | Almontaser Hussein Hekma Farghaly Eman Askar Kotb Metwalley Khaled Saad Asmaa Zahran Hisham A. Othman |
| author_sort | Almontaser Hussein |
| collection | DOAJ |
| description | Background: Accurate anthropometric measurements and critical analysis of growth data allow the clinician to promptly recognize children with short stature. The aim of this study was to determine the frequency of etiological factors causing short stature among children referred to the pediatric endocrinology clinic of Assiut University Children’s Hospital, the main tertiary care center in Upper Egypt. Methods: We conducted this descriptive observational study from May 2012 to December 2015, to analyze 637 children (boys 354, girls 283) with short stature. Evaluation included: detailed medical history, physical examination, laboratory tests, bone age and chromosomal analysis. Results: Endocrinological causes accounted for 26% of short stature [of them, 11.8% had growth hormone deficiency (GHD)], 63.6% had normal variants of growth [of them, 42% had familial short stature (FSS), 15.8% had constitutional growth delay (CGD) and 5.5% a combination of both]. Interestingly, celiac disease (CD) constituted 6.6% of children with short stature in our cohort. Conclusions: Although potentially treatable causes such as GHD, hypothyroidism and CD accounted for a considerable percentage of short stature in our study, the majority of short stature in children had normal variations of growth. Growth hormone treatment in children, however, should be promptly initiated with specific clinical indications. CD is a not uncommon cause of short stature. |
| first_indexed | 2024-12-23T06:09:59Z |
| format | Article |
| id | doaj.art-23cea3c2a7774e708e92021a101e887a |
| institution | Directory Open Access Journal |
| issn | 2042-0188 2042-0196 |
| language | English |
| last_indexed | 2024-12-23T06:09:59Z |
| publishDate | 2017-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Endocrinology and Metabolism |
| spelling | doaj.art-23cea3c2a7774e708e92021a101e887a2022-12-21T17:57:28ZengSAGE PublishingTherapeutic Advances in Endocrinology and Metabolism2042-01882042-01962017-05-01810.1177/2042018817707464Etiological factors of short stature in children and adolescents: experience at a tertiary care hospital in EgyptAlmontaser HusseinHekma FarghalyEman AskarKotb MetwalleyKhaled SaadAsmaa ZahranHisham A. OthmanBackground: Accurate anthropometric measurements and critical analysis of growth data allow the clinician to promptly recognize children with short stature. The aim of this study was to determine the frequency of etiological factors causing short stature among children referred to the pediatric endocrinology clinic of Assiut University Children’s Hospital, the main tertiary care center in Upper Egypt. Methods: We conducted this descriptive observational study from May 2012 to December 2015, to analyze 637 children (boys 354, girls 283) with short stature. Evaluation included: detailed medical history, physical examination, laboratory tests, bone age and chromosomal analysis. Results: Endocrinological causes accounted for 26% of short stature [of them, 11.8% had growth hormone deficiency (GHD)], 63.6% had normal variants of growth [of them, 42% had familial short stature (FSS), 15.8% had constitutional growth delay (CGD) and 5.5% a combination of both]. Interestingly, celiac disease (CD) constituted 6.6% of children with short stature in our cohort. Conclusions: Although potentially treatable causes such as GHD, hypothyroidism and CD accounted for a considerable percentage of short stature in our study, the majority of short stature in children had normal variations of growth. Growth hormone treatment in children, however, should be promptly initiated with specific clinical indications. CD is a not uncommon cause of short stature.https://doi.org/10.1177/2042018817707464 |
| spellingShingle | Almontaser Hussein Hekma Farghaly Eman Askar Kotb Metwalley Khaled Saad Asmaa Zahran Hisham A. Othman Etiological factors of short stature in children and adolescents: experience at a tertiary care hospital in Egypt Therapeutic Advances in Endocrinology and Metabolism |
| title | Etiological factors of short stature in children and adolescents: experience at a tertiary care hospital in Egypt |
| title_full | Etiological factors of short stature in children and adolescents: experience at a tertiary care hospital in Egypt |
| title_fullStr | Etiological factors of short stature in children and adolescents: experience at a tertiary care hospital in Egypt |
| title_full_unstemmed | Etiological factors of short stature in children and adolescents: experience at a tertiary care hospital in Egypt |
| title_short | Etiological factors of short stature in children and adolescents: experience at a tertiary care hospital in Egypt |
| title_sort | etiological factors of short stature in children and adolescents experience at a tertiary care hospital in egypt |
| url | https://doi.org/10.1177/2042018817707464 |
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