The assessment of new bone formation induced by unfocused extracorporeal shock wave therapy applied on pre-surgical phase of distraction osteogenesis
Purpose This study aims to evaluate the effects of extracorporeal shock wave therapy applied before and/or immediately after the osteotomy on the maturation during the consolidation phase. Materials and Methods 21 female New Zealand rabbits were used in the study. Subjects were divided randomly into...
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Istanbul University
2019-09-01
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| Series: | European Oral Research |
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| Online Access: | https://cdn.istanbul.edu.tr/file/1CD58DF90A/31B27E619E9042498565912BB80BA43A?doi=10.26650/eor.20190041 |
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| author | Erman Senel Enes Ozkan Mehmet Cihan Bereket Mehmet Emin Onger |
| author_facet | Erman Senel Enes Ozkan Mehmet Cihan Bereket Mehmet Emin Onger |
| author_sort | Erman Senel |
| collection | DOAJ |
| description | Purpose This study aims to evaluate the effects of extracorporeal shock wave therapy applied before and/or immediately after the osteotomy on the maturation during the consolidation phase. Materials and Methods 21 female New Zealand rabbits were used in the study. Subjects were divided randomly into three groups: Control (Distraction without ESWT), A (Distraction +ESWT After Osteotomy), AB (Distraction+ESWT After and Before Osteotomy). ESWT (500 pulses, 5 Hz, 0.19 mJ/mm2 energy flux density) was applied to group A and group AB after 5, 12 and 19 days after osteotomy and group AB only on days 7,14 and 21 before osteotomy. On the 28th day of the consolidation period, all subjects were sacrificed. Dual-energy x-ray absorptiometry (DEXA) was used to determine bone mineral density (BMD) and bone mineral content (BMC), and stereological methods were used to determine the new bone, connective tissue and neovascularization volumes. Results As a result of DEXA examinations made on the 1st and 4th week of consolidation, there was no significant difference between groups regarding BMD and BMC values. According to the results of stereological examination, when the connective tissue and new bone tissue were evaluated, higher values were observed in AB when compared to A, and in AB and A compared to the control group, but the differences are not statistically significant. There was no difference between the groups in terms of neovascularization. Conclusion ESWT in these parameters was not positively effective in bone maturation during consolidation when applied before osteotomy or both before and after osteotomy. |
| first_indexed | 2024-04-10T13:30:57Z |
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| id | doaj.art-23cf9a688c704623880ae315113c719d |
| institution | Directory Open Access Journal |
| issn | 2630-6158 2651-2823 |
| language | English |
| last_indexed | 2024-04-10T13:30:57Z |
| publishDate | 2019-09-01 |
| publisher | Istanbul University |
| record_format | Article |
| series | European Oral Research |
| spelling | doaj.art-23cf9a688c704623880ae315113c719d2023-02-15T16:11:33ZengIstanbul UniversityEuropean Oral Research2630-61582651-28232019-09-0153312513110.26650/eor.20190041The assessment of new bone formation induced by unfocused extracorporeal shock wave therapy applied on pre-surgical phase of distraction osteogenesisErman Senel0Enes Ozkan1Mehmet Cihan Bereket2Mehmet Emin Onger3Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Pamukkale University, Denizli, TurkeyDepartment of Oral and Maxillofacial Surgery, Faculty of Dentistry, Istanbul Medeniyet University, Istanbul, TurkeyDepartment of Oral and Maxillofacial Surgery, Faculty of Dentistry, Ondokuz Mayis University, Samsun, TurkeyDepartment of Histology and Embryology, Faculty of Medicine, Ondokuz Mayis University, Samsun, TurkePurpose This study aims to evaluate the effects of extracorporeal shock wave therapy applied before and/or immediately after the osteotomy on the maturation during the consolidation phase. Materials and Methods 21 female New Zealand rabbits were used in the study. Subjects were divided randomly into three groups: Control (Distraction without ESWT), A (Distraction +ESWT After Osteotomy), AB (Distraction+ESWT After and Before Osteotomy). ESWT (500 pulses, 5 Hz, 0.19 mJ/mm2 energy flux density) was applied to group A and group AB after 5, 12 and 19 days after osteotomy and group AB only on days 7,14 and 21 before osteotomy. On the 28th day of the consolidation period, all subjects were sacrificed. Dual-energy x-ray absorptiometry (DEXA) was used to determine bone mineral density (BMD) and bone mineral content (BMC), and stereological methods were used to determine the new bone, connective tissue and neovascularization volumes. Results As a result of DEXA examinations made on the 1st and 4th week of consolidation, there was no significant difference between groups regarding BMD and BMC values. According to the results of stereological examination, when the connective tissue and new bone tissue were evaluated, higher values were observed in AB when compared to A, and in AB and A compared to the control group, but the differences are not statistically significant. There was no difference between the groups in terms of neovascularization. Conclusion ESWT in these parameters was not positively effective in bone maturation during consolidation when applied before osteotomy or both before and after osteotomy.https://cdn.istanbul.edu.tr/file/1CD58DF90A/31B27E619E9042498565912BB80BA43A?doi=10.26650/eor.20190041Bone regeneration; distraction osteogenesis; dual-energy x-ray absorptiometry; extracorporeal shock wave therapy; organ volume |
| spellingShingle | Erman Senel Enes Ozkan Mehmet Cihan Bereket Mehmet Emin Onger The assessment of new bone formation induced by unfocused extracorporeal shock wave therapy applied on pre-surgical phase of distraction osteogenesis European Oral Research Bone regeneration; distraction osteogenesis; dual-energy x-ray absorptiometry; extracorporeal shock wave therapy; organ volume |
| title | The assessment of new bone formation induced by unfocused extracorporeal shock wave therapy applied on pre-surgical phase of distraction osteogenesis |
| title_full | The assessment of new bone formation induced by unfocused extracorporeal shock wave therapy applied on pre-surgical phase of distraction osteogenesis |
| title_fullStr | The assessment of new bone formation induced by unfocused extracorporeal shock wave therapy applied on pre-surgical phase of distraction osteogenesis |
| title_full_unstemmed | The assessment of new bone formation induced by unfocused extracorporeal shock wave therapy applied on pre-surgical phase of distraction osteogenesis |
| title_short | The assessment of new bone formation induced by unfocused extracorporeal shock wave therapy applied on pre-surgical phase of distraction osteogenesis |
| title_sort | assessment of new bone formation induced by unfocused extracorporeal shock wave therapy applied on pre surgical phase of distraction osteogenesis |
| topic | Bone regeneration; distraction osteogenesis; dual-energy x-ray absorptiometry; extracorporeal shock wave therapy; organ volume |
| url | https://cdn.istanbul.edu.tr/file/1CD58DF90A/31B27E619E9042498565912BB80BA43A?doi=10.26650/eor.20190041 |
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