An Unusual, Intermediate-Sized Lesion Affecting Motor Organization in a Patient With Schizencephaly: A Case Report
Schizencephalies are abnormal clefts of the cerebral hemispheres that result from abnormal late neuronal migration and cortical organization. In the present study, we report a different type of unusual motor organization in a patient with a schizencephalic cleft in the right hemisphere and polymicro...
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Frontiers Media S.A.
2020-07-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnhum.2020.00258/full |
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| author | Sung-Woon Baik Gi-Wook Kim Gi-Wook Kim Gi-Wook Kim Myoung-Hwan Ko Myoung-Hwan Ko Myoung-Hwan Ko Jeoung-Hwan Seo Jeoung-Hwan Seo Yu-Hui Won Yu-Hui Won Sung-Hee Park Sung-Hee Park |
| author_facet | Sung-Woon Baik Gi-Wook Kim Gi-Wook Kim Gi-Wook Kim Myoung-Hwan Ko Myoung-Hwan Ko Myoung-Hwan Ko Jeoung-Hwan Seo Jeoung-Hwan Seo Yu-Hui Won Yu-Hui Won Sung-Hee Park Sung-Hee Park |
| author_sort | Sung-Woon Baik |
| collection | DOAJ |
| description | Schizencephalies are abnormal clefts of the cerebral hemispheres that result from abnormal late neuronal migration and cortical organization. In the present study, we report a different type of unusual motor organization in a patient with a schizencephalic cleft in the right hemisphere and polymicrogyria in the opposite hemisphere. Despite similar brain pathology affecting the sensorimotor cortex, motor organization differed from previously known bilateral congenital brain lesions. We conducted a transcranial magnetic stimulation (TMS) and diffusion tensor image (DTI) study to confirm the motor organization. In this case, ipsilateral corticospinal projections to the paretic hands were observed during TMS of the less affected hemisphere, along with polymicrogyria, similar to the previous study. However, a crossed corticospinal tract to the paretic hand from the more severely affected hemisphere was observed in this case-a pattern of motor organization that has yet to be reported in this patient population. Our findings indicate that motor organization after early brain injury may be affected by the interhemispheric competition of the corticospinal system and bilateral brain lesions, thereby resulting in unilateral hemiparesis. |
| first_indexed | 2024-12-13T09:20:35Z |
| format | Article |
| id | doaj.art-23d07a3ebfda47db998762503bd5d01f |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-12-13T09:20:35Z |
| publishDate | 2020-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-23d07a3ebfda47db998762503bd5d01f2022-12-21T23:52:44ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612020-07-011410.3389/fnhum.2020.00258533852An Unusual, Intermediate-Sized Lesion Affecting Motor Organization in a Patient With Schizencephaly: A Case ReportSung-Woon Baik0Gi-Wook Kim1Gi-Wook Kim2Gi-Wook Kim3Myoung-Hwan Ko4Myoung-Hwan Ko5Myoung-Hwan Ko6Jeoung-Hwan Seo7Jeoung-Hwan Seo8Yu-Hui Won9Yu-Hui Won10Sung-Hee Park11Sung-Hee Park12Department of Physical Medicine and Rehabilitation, Chonbuk National University Hospital, Jeonju, South KoreaDepartment of Physical Medicine and Rehabilitation, Chonbuk National University Hospital, Jeonju, South KoreaResearch Institue of Clinical Medicine of Chonbuk National University—Biomedical Research Institue of Chonbuk National University Hospital, Jeonju, South KoreaTranslational Research & Clinical Trial Center for Medical Device, Chonbuk National University Hospital, Jeonju, South KoreaDepartment of Physical Medicine and Rehabilitation, Chonbuk National University Hospital, Jeonju, South KoreaResearch Institue of Clinical Medicine of Chonbuk National University—Biomedical Research Institue of Chonbuk National University Hospital, Jeonju, South KoreaTranslational Research & Clinical Trial Center for Medical Device, Chonbuk National University Hospital, Jeonju, South KoreaDepartment of Physical Medicine and Rehabilitation, Chonbuk National University Hospital, Jeonju, South KoreaResearch Institue of Clinical Medicine of Chonbuk National University—Biomedical Research Institue of Chonbuk National University Hospital, Jeonju, South KoreaDepartment of Physical Medicine and Rehabilitation, Chonbuk National University Hospital, Jeonju, South KoreaResearch Institue of Clinical Medicine of Chonbuk National University—Biomedical Research Institue of Chonbuk National University Hospital, Jeonju, South KoreaDepartment of Physical Medicine and Rehabilitation, Chonbuk National University Hospital, Jeonju, South KoreaResearch Institue of Clinical Medicine of Chonbuk National University—Biomedical Research Institue of Chonbuk National University Hospital, Jeonju, South KoreaSchizencephalies are abnormal clefts of the cerebral hemispheres that result from abnormal late neuronal migration and cortical organization. In the present study, we report a different type of unusual motor organization in a patient with a schizencephalic cleft in the right hemisphere and polymicrogyria in the opposite hemisphere. Despite similar brain pathology affecting the sensorimotor cortex, motor organization differed from previously known bilateral congenital brain lesions. We conducted a transcranial magnetic stimulation (TMS) and diffusion tensor image (DTI) study to confirm the motor organization. In this case, ipsilateral corticospinal projections to the paretic hands were observed during TMS of the less affected hemisphere, along with polymicrogyria, similar to the previous study. However, a crossed corticospinal tract to the paretic hand from the more severely affected hemisphere was observed in this case-a pattern of motor organization that has yet to be reported in this patient population. Our findings indicate that motor organization after early brain injury may be affected by the interhemispheric competition of the corticospinal system and bilateral brain lesions, thereby resulting in unilateral hemiparesis.https://www.frontiersin.org/article/10.3389/fnhum.2020.00258/fullschizencephalytranscranial magnetic stimulationdiffusion tensor imagingpolymicrogyriacongenital brain anomalies |
| spellingShingle | Sung-Woon Baik Gi-Wook Kim Gi-Wook Kim Gi-Wook Kim Myoung-Hwan Ko Myoung-Hwan Ko Myoung-Hwan Ko Jeoung-Hwan Seo Jeoung-Hwan Seo Yu-Hui Won Yu-Hui Won Sung-Hee Park Sung-Hee Park An Unusual, Intermediate-Sized Lesion Affecting Motor Organization in a Patient With Schizencephaly: A Case Report Frontiers in Human Neuroscience schizencephaly transcranial magnetic stimulation diffusion tensor imaging polymicrogyria congenital brain anomalies |
| title | An Unusual, Intermediate-Sized Lesion Affecting Motor Organization in a Patient With Schizencephaly: A Case Report |
| title_full | An Unusual, Intermediate-Sized Lesion Affecting Motor Organization in a Patient With Schizencephaly: A Case Report |
| title_fullStr | An Unusual, Intermediate-Sized Lesion Affecting Motor Organization in a Patient With Schizencephaly: A Case Report |
| title_full_unstemmed | An Unusual, Intermediate-Sized Lesion Affecting Motor Organization in a Patient With Schizencephaly: A Case Report |
| title_short | An Unusual, Intermediate-Sized Lesion Affecting Motor Organization in a Patient With Schizencephaly: A Case Report |
| title_sort | unusual intermediate sized lesion affecting motor organization in a patient with schizencephaly a case report |
| topic | schizencephaly transcranial magnetic stimulation diffusion tensor imaging polymicrogyria congenital brain anomalies |
| url | https://www.frontiersin.org/article/10.3389/fnhum.2020.00258/full |
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