COVID-19: a closer look at the pathology in two autopsied cases. Is the pericyte at the center of the pathological process in COVID-19?
We performed autopsies on two cases of COVID-19. The microcirculations of all organs were the site of the pathological findings. Thrombotic microangiopathy was found in the brain and also the kidneys. Vasculitis was also a feature of the autopsy findings, together with portal triaditis of the liver....
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
University of São Paulo
2021-05-01
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| Series: | Autopsy and Case Reports |
| Subjects: | |
| Online Access: | https://www.revistas.usp.br/autopsy/article/view/185593 |
| _version_ | 1818885595982725120 |
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| author | Hubert Daisley Jr Arlene Rampersad Martina Daisley Amit Ramdin Oneka Acco Farhaana Narinesingh Ornella Humphrey |
| author_facet | Hubert Daisley Jr Arlene Rampersad Martina Daisley Amit Ramdin Oneka Acco Farhaana Narinesingh Ornella Humphrey |
| author_sort | Hubert Daisley Jr |
| collection | DOAJ |
| description | We performed autopsies on two cases of COVID-19. The microcirculations of all organs were the site of the pathological findings. Thrombotic microangiopathy was found in the brain and also the kidneys. Vasculitis was also a feature of the autopsy findings, together with portal triaditis of the liver. The major pathological findings in both cases were fibrin deposits. Within the lung, the fibrin deposits were observed in the alveolar microcirculation in sub-endothelial locations of capillaries, arterioles, post capillary venules, and the adventitia of larger vessels. These fibrin deposits in the lungs occurred at the sites where pericytes are located in these vessels. The pericyte with its high concentration of ACE-2 receptors and its procoagulant state may represent one of the primary sites of action of SARS-CoV-2. A review of pericytes in health and disease is undertaken. COVID-19 is a disease of the microcirculation. |
| first_indexed | 2024-12-19T16:07:57Z |
| format | Article |
| id | doaj.art-23d46ae2c5f44b0bacf7b8d4dfbe59fa |
| institution | Directory Open Access Journal |
| issn | 2236-1960 |
| language | English |
| last_indexed | 2024-12-19T16:07:57Z |
| publishDate | 2021-05-01 |
| publisher | University of São Paulo |
| record_format | Article |
| series | Autopsy and Case Reports |
| spelling | doaj.art-23d46ae2c5f44b0bacf7b8d4dfbe59fa2022-12-21T20:14:48ZengUniversity of São PauloAutopsy and Case Reports2236-19602021-05-0111COVID-19: a closer look at the pathology in two autopsied cases. Is the pericyte at the center of the pathological process in COVID-19?Hubert Daisley Jr0Arlene Rampersad1Martina Daisley2Amit Ramdin3Oneka Acco4Farhaana Narinesingh5Ornella Humphrey6General Hospital San Fernando, Department of Pathology, Trinidad, West IndiesGeneral Hospital San Fernando, Department of Pathology, Trinidad, West Indies Scarborough General Hospital, Department of Accident and Emergency, Tobago, West IndiesGeneral Hospital San Fernando, Department of Pathology, Trinidad, West IndiesGeneral Hospital San Fernando, Department of Pathology, Trinidad, West IndiesGeneral Hospital San Fernando, Department of Pathology, Trinidad, West IndiesUniversity of the West Indies, St. Augustine, Trinidad, West IndiesWe performed autopsies on two cases of COVID-19. The microcirculations of all organs were the site of the pathological findings. Thrombotic microangiopathy was found in the brain and also the kidneys. Vasculitis was also a feature of the autopsy findings, together with portal triaditis of the liver. The major pathological findings in both cases were fibrin deposits. Within the lung, the fibrin deposits were observed in the alveolar microcirculation in sub-endothelial locations of capillaries, arterioles, post capillary venules, and the adventitia of larger vessels. These fibrin deposits in the lungs occurred at the sites where pericytes are located in these vessels. The pericyte with its high concentration of ACE-2 receptors and its procoagulant state may represent one of the primary sites of action of SARS-CoV-2. A review of pericytes in health and disease is undertaken. COVID-19 is a disease of the microcirculation.https://www.revistas.usp.br/autopsy/article/view/185593MicrocirculationPericytesFibrinSARS virus |
| spellingShingle | Hubert Daisley Jr Arlene Rampersad Martina Daisley Amit Ramdin Oneka Acco Farhaana Narinesingh Ornella Humphrey COVID-19: a closer look at the pathology in two autopsied cases. Is the pericyte at the center of the pathological process in COVID-19? Autopsy and Case Reports Microcirculation Pericytes Fibrin SARS virus |
| title | COVID-19: a closer look at the pathology in two autopsied cases. Is the pericyte at the center of the pathological process in COVID-19? |
| title_full | COVID-19: a closer look at the pathology in two autopsied cases. Is the pericyte at the center of the pathological process in COVID-19? |
| title_fullStr | COVID-19: a closer look at the pathology in two autopsied cases. Is the pericyte at the center of the pathological process in COVID-19? |
| title_full_unstemmed | COVID-19: a closer look at the pathology in two autopsied cases. Is the pericyte at the center of the pathological process in COVID-19? |
| title_short | COVID-19: a closer look at the pathology in two autopsied cases. Is the pericyte at the center of the pathological process in COVID-19? |
| title_sort | covid 19 a closer look at the pathology in two autopsied cases is the pericyte at the center of the pathological process in covid 19 |
| topic | Microcirculation Pericytes Fibrin SARS virus |
| url | https://www.revistas.usp.br/autopsy/article/view/185593 |
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