Nanoparticles as Physically- and Biochemically-Tuned Drug Formulations for Cancers Therapy
Malignant tumors originate from a combination of genetic alterations, which induce activation of oncogenes and inactivation of oncosuppressor genes, ultimately resulting in uncontrolled growth and neoplastic transformation. Chemotherapy prevents the abnormal proliferation of cancer cells, but it als...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/14/10/2473 |
| _version_ | 1797501023969869824 |
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| author | Valentina Foglizzo Serena Marchiò |
| author_facet | Valentina Foglizzo Serena Marchiò |
| author_sort | Valentina Foglizzo |
| collection | DOAJ |
| description | Malignant tumors originate from a combination of genetic alterations, which induce activation of oncogenes and inactivation of oncosuppressor genes, ultimately resulting in uncontrolled growth and neoplastic transformation. Chemotherapy prevents the abnormal proliferation of cancer cells, but it also affects the entire cellular network in the human body with heavy side effects. For this reason, the ultimate aim of cancer therapy remains to selectively kill cancer cells while sparing their normal counterparts. Nanoparticle formulations have the potential to achieve this aim by providing optimized drug delivery to a pathological site with minimal accumulation in healthy tissues. In this review, we will first describe the characteristics of recently developed nanoparticles and how their physical properties and targeting functionalization are exploited depending on their therapeutic payload, route of delivery, and tumor type. Second, we will analyze how nanoparticles can overcome multidrug resistance based on their ability to combine different therapies and targeting moieties within a single formulation. Finally, we will discuss how the implementation of these strategies has led to the generation of nanoparticle-based cancer vaccines as cutting-edge instruments for cancer immunotherapy. |
| first_indexed | 2024-03-10T03:12:19Z |
| format | Article |
| id | doaj.art-23d59a87f8f84048a27be5f2202baa1c |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T03:12:19Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-23d59a87f8f84048a27be5f2202baa1c2023-11-23T10:23:42ZengMDPI AGCancers2072-66942022-05-011410247310.3390/cancers14102473Nanoparticles as Physically- and Biochemically-Tuned Drug Formulations for Cancers TherapyValentina Foglizzo0Serena Marchiò1Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136, USADepartment of Oncology, University of Torino, 10060 Candiolo, ItalyMalignant tumors originate from a combination of genetic alterations, which induce activation of oncogenes and inactivation of oncosuppressor genes, ultimately resulting in uncontrolled growth and neoplastic transformation. Chemotherapy prevents the abnormal proliferation of cancer cells, but it also affects the entire cellular network in the human body with heavy side effects. For this reason, the ultimate aim of cancer therapy remains to selectively kill cancer cells while sparing their normal counterparts. Nanoparticle formulations have the potential to achieve this aim by providing optimized drug delivery to a pathological site with minimal accumulation in healthy tissues. In this review, we will first describe the characteristics of recently developed nanoparticles and how their physical properties and targeting functionalization are exploited depending on their therapeutic payload, route of delivery, and tumor type. Second, we will analyze how nanoparticles can overcome multidrug resistance based on their ability to combine different therapies and targeting moieties within a single formulation. Finally, we will discuss how the implementation of these strategies has led to the generation of nanoparticle-based cancer vaccines as cutting-edge instruments for cancer immunotherapy.https://www.mdpi.com/2072-6694/14/10/2473nanoparticlesdrug deliverytarget therapycancer vaccinecancer immunotherapy |
| spellingShingle | Valentina Foglizzo Serena Marchiò Nanoparticles as Physically- and Biochemically-Tuned Drug Formulations for Cancers Therapy Cancers nanoparticles drug delivery target therapy cancer vaccine cancer immunotherapy |
| title | Nanoparticles as Physically- and Biochemically-Tuned Drug Formulations for Cancers Therapy |
| title_full | Nanoparticles as Physically- and Biochemically-Tuned Drug Formulations for Cancers Therapy |
| title_fullStr | Nanoparticles as Physically- and Biochemically-Tuned Drug Formulations for Cancers Therapy |
| title_full_unstemmed | Nanoparticles as Physically- and Biochemically-Tuned Drug Formulations for Cancers Therapy |
| title_short | Nanoparticles as Physically- and Biochemically-Tuned Drug Formulations for Cancers Therapy |
| title_sort | nanoparticles as physically and biochemically tuned drug formulations for cancers therapy |
| topic | nanoparticles drug delivery target therapy cancer vaccine cancer immunotherapy |
| url | https://www.mdpi.com/2072-6694/14/10/2473 |
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