TNF stimulation primarily modulates transcriptional burst size of NF‐κB‐regulated genes

TNF stimulation primarily modulates transcriptional burst size of NF‐κB‐regulated genes

Abstract Cell‐to‐cell heterogeneity is a feature of the tumor necrosis factor (TNF)‐stimulated inflammatory response mediated by the transcription factor NF‐κB, motivating an exploration of the underlying sources of this noise. Here, we combined single‐transcript measurements with computational mode...

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Bibliographic Details
Main Authors: Victor L Bass, Victor C Wong, M Elise Bullock, Suzanne Gaudet, Kathryn Miller‐Jensen
Format: Article
Language:English
Published: Springer Nature 2021-07-01
Series:Molecular Systems Biology
Subjects:
inflammation
NF‐κB
TNF
transcriptional bursting
Online Access:https://doi.org/10.15252/msb.202010127

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