Gingival Manifestations in Oral Chronic Autoimmune Bullous Diseases: A Retrospective Study
<i>Background and Objectives</i>: Desquamative gingivitis (DG) is a clinical term indicating “peeling gums” and is associated with different oral manifestations. In this study, we aimed to assess the association between DG and autoimmune blistering mucocutaneous diseases (ABMD) with oral...
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MDPI AG
2024-01-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/60/1/167 |
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| author | Ioanina Parlatescu Serban Tovaru Cristina Tofan Paula Perlea Elena Milanesi Maria Dobre Laurenta Lelia Mihai |
| author_facet | Ioanina Parlatescu Serban Tovaru Cristina Tofan Paula Perlea Elena Milanesi Maria Dobre Laurenta Lelia Mihai |
| author_sort | Ioanina Parlatescu |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: Desquamative gingivitis (DG) is a clinical term indicating “peeling gums” and is associated with different oral manifestations. In this study, we aimed to assess the association between DG and autoimmune blistering mucocutaneous diseases (ABMD) with oral manifestations. <i>Materials and Methods</i>: A retrospective study including 88 patients diagnosed between 1998 and 2019 with ABMD (intraepithelial and subepithelial autoimmune blistering diseases) was performed at the Oral Medicine Department, Faculty of Dentistry, “Carol Davila” University of Medicine and Pharmacy in Bucharest. For each patient, the sociodemographic and anamnestic data, as well as clinical features of oral lesions (location), histological evaluation, and direct immunofluorescence data were collected. <i>Results</i>: Most of the patients involved in the study were female (78.4%). In total, 34 patients (38.63%) were diagnosed with subepithelial autoimmune diseases (SAD) and 54 (61.36%) had intraepithelial autoimmune diseases (IAD). Differences in the anatomic distribution of oral involvement were found between SAD and IAD. The presence of DG was significantly more common in patients with SAD compared to those with a diagnosis of IAD. <i>Conclusions</i>: Specific anatomical locations of the oral lesions are significantly associated with different subtypes of ABMD, with gingiva and hard palate mucosa being more involved in SAD and the soft palate and buccal mucosa in IAD. Desquamative gingivitis is a clinical sign that raises diagnostic challenges for several conditions in oral medicine. |
| first_indexed | 2024-03-08T10:41:03Z |
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| language | English |
| last_indexed | 2024-03-08T10:41:03Z |
| publishDate | 2024-01-01 |
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| series | Medicina |
| spelling | doaj.art-23d6cab48a334a9c91ef6f88418965552024-01-26T17:35:43ZengMDPI AGMedicina1010-660X1648-91442024-01-0160116710.3390/medicina60010167Gingival Manifestations in Oral Chronic Autoimmune Bullous Diseases: A Retrospective StudyIoanina Parlatescu0Serban Tovaru1Cristina Tofan2Paula Perlea3Elena Milanesi4Maria Dobre5Laurenta Lelia Mihai6Faculty of Dentistry, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, RomaniaFaculty of Dentistry, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, RomaniaPrivate Dental Practice, Dimitrie Cantemir Street, no 11, bl. 8, ap. 46, 040233 Bucharest, RomaniaFaculty of Dentistry, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, RomaniaFaculty of Medicine, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, RomaniaVictor Babeș National Institute of Pathology, 050096 Bucharest, RomaniaFaculty of Dental Medicine, “Titu Maiorescu” University of Bucharest, 031593 Bucharest, Romania<i>Background and Objectives</i>: Desquamative gingivitis (DG) is a clinical term indicating “peeling gums” and is associated with different oral manifestations. In this study, we aimed to assess the association between DG and autoimmune blistering mucocutaneous diseases (ABMD) with oral manifestations. <i>Materials and Methods</i>: A retrospective study including 88 patients diagnosed between 1998 and 2019 with ABMD (intraepithelial and subepithelial autoimmune blistering diseases) was performed at the Oral Medicine Department, Faculty of Dentistry, “Carol Davila” University of Medicine and Pharmacy in Bucharest. For each patient, the sociodemographic and anamnestic data, as well as clinical features of oral lesions (location), histological evaluation, and direct immunofluorescence data were collected. <i>Results</i>: Most of the patients involved in the study were female (78.4%). In total, 34 patients (38.63%) were diagnosed with subepithelial autoimmune diseases (SAD) and 54 (61.36%) had intraepithelial autoimmune diseases (IAD). Differences in the anatomic distribution of oral involvement were found between SAD and IAD. The presence of DG was significantly more common in patients with SAD compared to those with a diagnosis of IAD. <i>Conclusions</i>: Specific anatomical locations of the oral lesions are significantly associated with different subtypes of ABMD, with gingiva and hard palate mucosa being more involved in SAD and the soft palate and buccal mucosa in IAD. Desquamative gingivitis is a clinical sign that raises diagnostic challenges for several conditions in oral medicine.https://www.mdpi.com/1648-9144/60/1/167bullous lesionsgingival diseasesmucous membrane pemphigoidoral mucosapemphigus |
| spellingShingle | Ioanina Parlatescu Serban Tovaru Cristina Tofan Paula Perlea Elena Milanesi Maria Dobre Laurenta Lelia Mihai Gingival Manifestations in Oral Chronic Autoimmune Bullous Diseases: A Retrospective Study Medicina bullous lesions gingival diseases mucous membrane pemphigoid oral mucosa pemphigus |
| title | Gingival Manifestations in Oral Chronic Autoimmune Bullous Diseases: A Retrospective Study |
| title_full | Gingival Manifestations in Oral Chronic Autoimmune Bullous Diseases: A Retrospective Study |
| title_fullStr | Gingival Manifestations in Oral Chronic Autoimmune Bullous Diseases: A Retrospective Study |
| title_full_unstemmed | Gingival Manifestations in Oral Chronic Autoimmune Bullous Diseases: A Retrospective Study |
| title_short | Gingival Manifestations in Oral Chronic Autoimmune Bullous Diseases: A Retrospective Study |
| title_sort | gingival manifestations in oral chronic autoimmune bullous diseases a retrospective study |
| topic | bullous lesions gingival diseases mucous membrane pemphigoid oral mucosa pemphigus |
| url | https://www.mdpi.com/1648-9144/60/1/167 |
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