Flavonoids Affect Host-Microbiota Crosstalk through TLR Modulation
Interaction between host cells and microbes is known as crosstalk. Among other mechanisms, this takes place when certain molecules of the micro-organisms are recognized by the toll-like receptors (TLRs) in the body cells, mainly in the intestinal epithelial cells and in the immune cells. TLRs belong...
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| Format: | Article |
| Language: | English |
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MDPI AG
2014-10-01
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| Series: | Antioxidants |
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| Online Access: | http://www.mdpi.com/2076-3921/3/4/649 |
| _version_ | 1797763060354514944 |
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| author | Francisco J. Pérez-Cano Malen Massot-Cladera Maria J. Rodríguez-Lagunas Margarida Castell |
| author_facet | Francisco J. Pérez-Cano Malen Massot-Cladera Maria J. Rodríguez-Lagunas Margarida Castell |
| author_sort | Francisco J. Pérez-Cano |
| collection | DOAJ |
| description | Interaction between host cells and microbes is known as crosstalk. Among other mechanisms, this takes place when certain molecules of the micro-organisms are recognized by the toll-like receptors (TLRs) in the body cells, mainly in the intestinal epithelial cells and in the immune cells. TLRs belong to the pattern-recognition receptors and represent the first line of defense against pathogens, playing a pivotal role in both innate and adaptive immunity. Dysregulation in the activity of such receptors can lead to the development of chronic and severe inflammation as well as immunological disorders. Among components present in the diet, flavonoids have been suggested as antioxidant dietary factors able to modulate TLR-mediated signaling pathways. This review focuses on the molecular targets involved in the modulatory action of flavonoids on TLR-mediated signaling pathways, providing an overview of the mechanisms involved in such action. Particular flavonoids have been able to modify the composition of the microbiota, to modulate TLR gene and protein expression, and to regulate the downstream signaling molecules involved in the TLR pathway. These synergistic mechanisms suggest the role of some flavonoids in the preventive effect on certain chronic diseases. |
| first_indexed | 2024-03-12T19:36:11Z |
| format | Article |
| id | doaj.art-23d7bf17aeeb401982d437331e014619 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-12T19:36:11Z |
| publishDate | 2014-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-23d7bf17aeeb401982d437331e0146192023-08-02T04:07:36ZengMDPI AGAntioxidants2076-39212014-10-013464967010.3390/antiox3040649antiox3040649Flavonoids Affect Host-Microbiota Crosstalk through TLR ModulationFrancisco J. Pérez-Cano0Malen Massot-Cladera1Maria J. Rodríguez-Lagunas2Margarida Castell3Departament de Fisiologia, Facultat de Farmàcia, Universitat de Barcelona, SpainDepartament de Fisiologia, Facultat de Farmàcia, Universitat de Barcelona, SpainInstitut de Recerca en Nutrició i Seguretat Alimentària (INSA-UB), E-08028 Barcelona, SpainDepartament de Fisiologia, Facultat de Farmàcia, Universitat de Barcelona, SpainInteraction between host cells and microbes is known as crosstalk. Among other mechanisms, this takes place when certain molecules of the micro-organisms are recognized by the toll-like receptors (TLRs) in the body cells, mainly in the intestinal epithelial cells and in the immune cells. TLRs belong to the pattern-recognition receptors and represent the first line of defense against pathogens, playing a pivotal role in both innate and adaptive immunity. Dysregulation in the activity of such receptors can lead to the development of chronic and severe inflammation as well as immunological disorders. Among components present in the diet, flavonoids have been suggested as antioxidant dietary factors able to modulate TLR-mediated signaling pathways. This review focuses on the molecular targets involved in the modulatory action of flavonoids on TLR-mediated signaling pathways, providing an overview of the mechanisms involved in such action. Particular flavonoids have been able to modify the composition of the microbiota, to modulate TLR gene and protein expression, and to regulate the downstream signaling molecules involved in the TLR pathway. These synergistic mechanisms suggest the role of some flavonoids in the preventive effect on certain chronic diseases.http://www.mdpi.com/2076-3921/3/4/649TLRpolyphenolsinflammationvegetablesintracellular signaling |
| spellingShingle | Francisco J. Pérez-Cano Malen Massot-Cladera Maria J. Rodríguez-Lagunas Margarida Castell Flavonoids Affect Host-Microbiota Crosstalk through TLR Modulation Antioxidants TLR polyphenols inflammation vegetables intracellular signaling |
| title | Flavonoids Affect Host-Microbiota Crosstalk through TLR Modulation |
| title_full | Flavonoids Affect Host-Microbiota Crosstalk through TLR Modulation |
| title_fullStr | Flavonoids Affect Host-Microbiota Crosstalk through TLR Modulation |
| title_full_unstemmed | Flavonoids Affect Host-Microbiota Crosstalk through TLR Modulation |
| title_short | Flavonoids Affect Host-Microbiota Crosstalk through TLR Modulation |
| title_sort | flavonoids affect host microbiota crosstalk through tlr modulation |
| topic | TLR polyphenols inflammation vegetables intracellular signaling |
| url | http://www.mdpi.com/2076-3921/3/4/649 |
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