Analysis of the electron-stream effect in patients treated with partial breast irradiation using the 1.5 T MR-linear accelerator
Introduction: The hybrid magnetic resonance linear accelerator (MRL) has the potential to test novel concepts in breast cancer patients such as daily MR-guided real-time plan adaptation. Before starting clinical trials, preparatory studies for example of the MR-dependent electron stream effect (ESE)...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-03-01
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| Series: | Clinical and Translational Radiation Oncology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405630820301105 |
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| author | C. De-Colle M. Nachbar D. Mӧnnich S. Boeke C. Gani N. Weidner V. Heinrich J. Winter S. Tsitsekidis O. Dohm D. Zips D. Thorwarth |
| author_facet | C. De-Colle M. Nachbar D. Mӧnnich S. Boeke C. Gani N. Weidner V. Heinrich J. Winter S. Tsitsekidis O. Dohm D. Zips D. Thorwarth |
| author_sort | C. De-Colle |
| collection | DOAJ |
| description | Introduction: The hybrid magnetic resonance linear accelerator (MRL) has the potential to test novel concepts in breast cancer patients such as daily MR-guided real-time plan adaptation. Before starting clinical trials, preparatory studies for example of the MR-dependent electron stream effect (ESE) are necessary. Material and Methods: To prospectively investigate the ESE, data from 11 patients treated with partial breast irradiation (PBI) at the 1.5 T MRL were evaluated. A bolus was placed on the chin and in vivo dosimetry results were compared with the dose simulated by the treatment planning system (TPS). The same measurements were carried out for three patients treated at a conventional linac. Toxicity and cosmesis were evaluated. Results: Median doses measured and simulated on top/ underneath the bolus were 1.91 / 0.62 Gy and 2.82 / 0.63 Gy, respectively. Median differences between calculations and measurements were 0.8 Gy and 0.1 Gy. At the conventional linac, median measured doses on top/ underneath the bolus were 0.98 and 1.37 Gy. No acute toxicity exceeding grade 2 was recorded. Cosmesis was good or excellent and patient reported outcome measures were mostly scored as none or mild. Conclusion: The dose due to the ESE is low, correctly predicted by the TPS and effectively minimized by a bolus. |
| first_indexed | 2024-12-14T09:57:27Z |
| format | Article |
| id | doaj.art-23d7c93cf5914498b564c03e6b9d03e1 |
| institution | Directory Open Access Journal |
| issn | 2405-6308 |
| language | English |
| last_indexed | 2024-12-14T09:57:27Z |
| publishDate | 2021-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Clinical and Translational Radiation Oncology |
| spelling | doaj.art-23d7c93cf5914498b564c03e6b9d03e12022-12-21T23:07:20ZengElsevierClinical and Translational Radiation Oncology2405-63082021-03-0127103108Analysis of the electron-stream effect in patients treated with partial breast irradiation using the 1.5 T MR-linear acceleratorC. De-Colle0M. Nachbar1D. Mӧnnich2S. Boeke3C. Gani4N. Weidner5V. Heinrich6J. Winter7S. Tsitsekidis8O. Dohm9D. Zips10D. Thorwarth11Department of Radiation Oncology, University Hospital and Medical Faculty, Eberhard Karls University Tübingen, Tübingen, Germany; Corresponding author at: Hoppe Seyler Strasse 3, 72076 Tübingen, Germany.Section for Biomedical Physics, Department of Radiation Oncology, University Hospital and Medical Faculty, Eberhard Karls University Tübingen, Tübingen, GermanySection for Biomedical Physics, Department of Radiation Oncology, University Hospital and Medical Faculty, Eberhard Karls University Tübingen, Tübingen, Germany; German Cancer Consortium (DKTK), Partner Site Tübingen, Heidelberg, Germany; German Cancer Research Center (DKFZ), Heidelberg, GermanyDepartment of Radiation Oncology, University Hospital and Medical Faculty, Eberhard Karls University Tübingen, Tübingen, GermanyDepartment of Radiation Oncology, University Hospital and Medical Faculty, Eberhard Karls University Tübingen, Tübingen, GermanyDepartment of Radiation Oncology, University Hospital and Medical Faculty, Eberhard Karls University Tübingen, Tübingen, GermanyDepartment of Radiation Oncology, University Hospital and Medical Faculty, Eberhard Karls University Tübingen, Tübingen, GermanySection for Biomedical Physics, Department of Radiation Oncology, University Hospital and Medical Faculty, Eberhard Karls University Tübingen, Tübingen, GermanySection for Biomedical Physics, Department of Radiation Oncology, University Hospital and Medical Faculty, Eberhard Karls University Tübingen, Tübingen, GermanySection for Biomedical Physics, Department of Radiation Oncology, University Hospital and Medical Faculty, Eberhard Karls University Tübingen, Tübingen, GermanyDepartment of Radiation Oncology, University Hospital and Medical Faculty, Eberhard Karls University Tübingen, Tübingen, Germany; German Cancer Consortium (DKTK), Partner Site Tübingen, Heidelberg, Germany; German Cancer Research Center (DKFZ), Heidelberg, GermanySection for Biomedical Physics, Department of Radiation Oncology, University Hospital and Medical Faculty, Eberhard Karls University Tübingen, Tübingen, Germany; German Cancer Consortium (DKTK), Partner Site Tübingen, Heidelberg, Germany; German Cancer Research Center (DKFZ), Heidelberg, GermanyIntroduction: The hybrid magnetic resonance linear accelerator (MRL) has the potential to test novel concepts in breast cancer patients such as daily MR-guided real-time plan adaptation. Before starting clinical trials, preparatory studies for example of the MR-dependent electron stream effect (ESE) are necessary. Material and Methods: To prospectively investigate the ESE, data from 11 patients treated with partial breast irradiation (PBI) at the 1.5 T MRL were evaluated. A bolus was placed on the chin and in vivo dosimetry results were compared with the dose simulated by the treatment planning system (TPS). The same measurements were carried out for three patients treated at a conventional linac. Toxicity and cosmesis were evaluated. Results: Median doses measured and simulated on top/ underneath the bolus were 1.91 / 0.62 Gy and 2.82 / 0.63 Gy, respectively. Median differences between calculations and measurements were 0.8 Gy and 0.1 Gy. At the conventional linac, median measured doses on top/ underneath the bolus were 0.98 and 1.37 Gy. No acute toxicity exceeding grade 2 was recorded. Cosmesis was good or excellent and patient reported outcome measures were mostly scored as none or mild. Conclusion: The dose due to the ESE is low, correctly predicted by the TPS and effectively minimized by a bolus.http://www.sciencedirect.com/science/article/pii/S2405630820301105Partial breast irradiationMR linear acceleratorMRLElectron stream effectToxicityCosmesis |
| spellingShingle | C. De-Colle M. Nachbar D. Mӧnnich S. Boeke C. Gani N. Weidner V. Heinrich J. Winter S. Tsitsekidis O. Dohm D. Zips D. Thorwarth Analysis of the electron-stream effect in patients treated with partial breast irradiation using the 1.5 T MR-linear accelerator Clinical and Translational Radiation Oncology Partial breast irradiation MR linear accelerator MRL Electron stream effect Toxicity Cosmesis |
| title | Analysis of the electron-stream effect in patients treated with partial breast irradiation using the 1.5 T MR-linear accelerator |
| title_full | Analysis of the electron-stream effect in patients treated with partial breast irradiation using the 1.5 T MR-linear accelerator |
| title_fullStr | Analysis of the electron-stream effect in patients treated with partial breast irradiation using the 1.5 T MR-linear accelerator |
| title_full_unstemmed | Analysis of the electron-stream effect in patients treated with partial breast irradiation using the 1.5 T MR-linear accelerator |
| title_short | Analysis of the electron-stream effect in patients treated with partial breast irradiation using the 1.5 T MR-linear accelerator |
| title_sort | analysis of the electron stream effect in patients treated with partial breast irradiation using the 1 5 t mr linear accelerator |
| topic | Partial breast irradiation MR linear accelerator MRL Electron stream effect Toxicity Cosmesis |
| url | http://www.sciencedirect.com/science/article/pii/S2405630820301105 |
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