BamQuery: a proteogenomic tool to explore the immunopeptidome and prioritize actionable tumor antigens

BamQuery: a proteogenomic tool to explore the immunopeptidome and prioritize actionable tumor antigens

Abstract MHC-I-associated peptides deriving from non-coding genomic regions and mutations can generate tumor-specific antigens, including neoantigens. Quantifying tumor-specific antigens’ RNA expression in malignant and benign tissues is critical for discriminating actionable targets. We present Bam...

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Bibliographic Details
Main Authors: Maria Virginia Ruiz Cuevas, Marie-Pierre Hardy, Jean-David Larouche, Anca Apavaloaei, Eralda Kina, Krystel Vincent, Patrick Gendron, Jean-Philippe Laverdure, Chantal Durette, Pierre Thibault, Sébastien Lemieux, Claude Perreault, Grégory Ehx
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Genome Biology
Subjects:
Immunopeptidome
Computational biology
Major histocompatibility complex
Tumor antigens
Online Access:https://doi.org/10.1186/s13059-023-03029-1

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