Exploring the therapeutic potential of isoorientin in the treatment of osteoporosis: a study using network pharmacology and experimental validation

Exploring the therapeutic potential of isoorientin in the treatment of osteoporosis: a study using network pharmacology and experimental validation

Abstract Background Isoorientin (ISO) is a glycosylated flavonoid with antitumor, anti-inflammatory, and antioxidant properties. However, its effects on bone metabolism remain largely unknown. Methods In this study, we aimed to investigate the effects of ISO on receptor activator of nuclear factor-κ...

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Bibliographic Details
Main Authors:	Bo Zhang, Zechao Qu, Hua Hui, Baorong He, Dong Wang, Yong Zhang, Yiwei Zhao, Jingjun Zhang, Liang Yan
Format:	Article
Language:	English
Published:	BMC 2024-02-01
Series:	Molecular Medicine
Subjects:	Osteoclast Receptor activator of nuclear factor-κB ligand (RANKL) Reactive oxygen species (ROS) Isoorientin (ISO) Nuclear factor erythroid 2‐related factor 2(Nrf2)
Online Access:	https://doi.org/10.1186/s10020-024-00799-7

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