Ischemic long-term-potentiation (iLTP): perspectives to set the threshold of neural plasticity toward therapy
The precise role of neural plasticity under pathological conditions remains not well understood. It appears to be well accepted, however, that changes in the ability of neurons to express plasticity accompany neurological diseases. Here, we discuss recent experimental evidence, which suggests that s...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2015-01-01
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| Series: | Neural Regeneration Research |
| Subjects: | |
| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=10;spage=1537;epage=1539;aulast=Lenz |
| _version_ | 1819228175685648384 |
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| author | Maximilian Lenz Andreas Vlachos Nicola Maggio |
| author_facet | Maximilian Lenz Andreas Vlachos Nicola Maggio |
| author_sort | Maximilian Lenz |
| collection | DOAJ |
| description | The precise role of neural plasticity under pathological conditions remains not well understood. It appears to be well accepted, however, that changes in the ability of neurons to express plasticity accompany neurological diseases. Here, we discuss recent experimental evidence, which suggests that synaptic plasticity induced by a pathological stimulus, i.e., ischemic long-term-potentiation (iLTP) of excitatory synapses, could play an important role for post-stroke recovery by influencing the post-lesional reorganization of surviving neuronal networks. |
| first_indexed | 2024-12-23T10:53:06Z |
| format | Article |
| id | doaj.art-23daba338129443e89b3d2a92f39dc5e |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-12-23T10:53:06Z |
| publishDate | 2015-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-23daba338129443e89b3d2a92f39dc5e2022-12-21T17:49:50ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742015-01-0110101537153910.4103/1673-5374.165215Ischemic long-term-potentiation (iLTP): perspectives to set the threshold of neural plasticity toward therapyMaximilian LenzAndreas VlachosNicola MaggioThe precise role of neural plasticity under pathological conditions remains not well understood. It appears to be well accepted, however, that changes in the ability of neurons to express plasticity accompany neurological diseases. Here, we discuss recent experimental evidence, which suggests that synaptic plasticity induced by a pathological stimulus, i.e., ischemic long-term-potentiation (iLTP) of excitatory synapses, could play an important role for post-stroke recovery by influencing the post-lesional reorganization of surviving neuronal networks.http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=10;spage=1537;epage=1539;aulast=Lenzischemic LTP (iLTP); stroke; neural repair; synaptic plasticity; neural homeostasis |
| spellingShingle | Maximilian Lenz Andreas Vlachos Nicola Maggio Ischemic long-term-potentiation (iLTP): perspectives to set the threshold of neural plasticity toward therapy Neural Regeneration Research ischemic LTP (iLTP); stroke; neural repair; synaptic plasticity; neural homeostasis |
| title | Ischemic long-term-potentiation (iLTP): perspectives to set the threshold of neural plasticity toward therapy |
| title_full | Ischemic long-term-potentiation (iLTP): perspectives to set the threshold of neural plasticity toward therapy |
| title_fullStr | Ischemic long-term-potentiation (iLTP): perspectives to set the threshold of neural plasticity toward therapy |
| title_full_unstemmed | Ischemic long-term-potentiation (iLTP): perspectives to set the threshold of neural plasticity toward therapy |
| title_short | Ischemic long-term-potentiation (iLTP): perspectives to set the threshold of neural plasticity toward therapy |
| title_sort | ischemic long term potentiation iltp perspectives to set the threshold of neural plasticity toward therapy |
| topic | ischemic LTP (iLTP); stroke; neural repair; synaptic plasticity; neural homeostasis |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=10;spage=1537;epage=1539;aulast=Lenz |
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