Expression of R345W-Fibulin-3 Induces Epithelial-Mesenchymal Transition in Retinal Pigment Epithelial Cells

Expression of R345W-Fibulin-3 Induces Epithelial-Mesenchymal Transition in Retinal Pigment Epithelial Cells

PurposeTo investigate the role of protein misfolding in retinal pigment epithelial (RPE) cell dysfunction, the effects of R345W-Fibulin-3 expression on RPE cell phenotype were studied.MethodsPrimary RPE cells were cultured to confluence on Transwells and infected with lentivirus constructs to expres...

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Bibliographic Details
Main Authors: Mi Zhou, Sarah R. Weber, Yuanjun Zhao, Han Chen, Alistair J. Barber, Stephanie L. Grillo, Carson A. Wills, Hong Gang Wang, John D. Hulleman, Jeffrey M. Sundstrom
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
RPE
dedifferentiation
EMT
protein misfolding
macular degeneration
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00469/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.00469/full

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