A GATA2-CDC6 axis modulates androgen receptor blockade-induced senescence in prostate cancer

A GATA2-CDC6 axis modulates androgen receptor blockade-induced senescence in prostate cancer

Abstract Background Prostate cancer is a major cause of cancer morbidity and mortality in men worldwide. Androgen deprivation therapy (ADT) has proven effective in early-stage androgen-sensitive disease, but prostate cancer gradually develops into an androgen-resistant metastatic state in the vast m...

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Main Authors: Ioanna Mourkioti, Aikaterini Polyzou, Dimitris Veroutis, George Theocharous, Nefeli Lagopati, Emanuela Gentile, Vasiliki Stravokefalou, Dimitris-Foivos Thanos, Sophia Havaki, Dimitris Kletsas, Theocharis Panaretakis, Christopher J. Logothetis, Dimitris Stellas, Russell Petty, Giovanni Blandino, Angelos Papaspyropoulos, Vassilis G. Gorgoulis
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Prostate cancer
AR signaling blockade
Enzalutamide
GATA2-CDC6 axis
Cellular senescence
Online Access:https://doi.org/10.1186/s13046-023-02769-z

Internet

https://doi.org/10.1186/s13046-023-02769-z

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