Reaching Deeper: Absolute In Vivo Thermal Reading of Liver by Combining Superbright Ag2S Nanothermometers and In Silico Simulations
Abstract Luminescent nano‐thermometry is a fast‐developing technique with great potential for in vivo sensing, diagnosis, and therapy. Unfortunately, it presents serious limitations. The luminescence generated by nanothermometers, from which thermal readout is obtained, is strongly distorted by the...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-05-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202003838 |
| _version_ | 1818672799096504320 |
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| author | José Lifante Yingli Shen Irene Zabala Gutierrez Irene Rubia‐Rodríguez Daniel Ortega Nuria Fernandez Sonia Melle Miriam Granado Jorge Rubio‐Retama Daniel Jaque Erving Ximendes |
| author_facet | José Lifante Yingli Shen Irene Zabala Gutierrez Irene Rubia‐Rodríguez Daniel Ortega Nuria Fernandez Sonia Melle Miriam Granado Jorge Rubio‐Retama Daniel Jaque Erving Ximendes |
| author_sort | José Lifante |
| collection | DOAJ |
| description | Abstract Luminescent nano‐thermometry is a fast‐developing technique with great potential for in vivo sensing, diagnosis, and therapy. Unfortunately, it presents serious limitations. The luminescence generated by nanothermometers, from which thermal readout is obtained, is strongly distorted by the attenuation induced by tissues. Such distortions lead to low signal levels and entangle absolute and reliable thermal monitoring of internal organs. Overcoming both limitations requires the use of high‐brightness luminescent nanothermometers and adopting more complex approaches for temperature estimation. In this work, it is demonstrated how superbright Ag2S nanothermometers can provide in vivo, reliable, and absolute thermal reading of the liver during laser‐induced hyperthermia. For that, a new procedure is designed in which thermal readout is obtained from the combination of in vivo transient thermometry measurements and in silico simulations. The synergy between in vivo and in silico measurements has made it possible to assess relevant numbers such as the efficiency of hyperthermia processes, the total heat energy deposited in the liver, and the relative contribution of Ag2S nanoparticles to liver heating. This work provides a new way for absolute thermal sensing of internal organs with potential application not only to hyperthermia processes but also to advanced diagnosis and therapy. |
| first_indexed | 2024-12-17T07:45:38Z |
| format | Article |
| id | doaj.art-23dc6a7fecd74ae7b4d7f30d28a08be2 |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-12-17T07:45:38Z |
| publishDate | 2021-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-23dc6a7fecd74ae7b4d7f30d28a08be22022-12-21T21:58:01ZengWileyAdvanced Science2198-38442021-05-0189n/an/a10.1002/advs.202003838Reaching Deeper: Absolute In Vivo Thermal Reading of Liver by Combining Superbright Ag2S Nanothermometers and In Silico SimulationsJosé Lifante0Yingli Shen1Irene Zabala Gutierrez2Irene Rubia‐Rodríguez3Daniel Ortega4Nuria Fernandez5Sonia Melle6Miriam Granado7Jorge Rubio‐Retama8Daniel Jaque9Erving Ximendes10Nanomaterials for Bioimaging Group (NanoBIG) Departamento de Fisiología ‐ Facultad de Medicina Universidad Autónoma de Madrid Arzobispo Morcillo 2 Madrid 28029 SpainNanomaterials for Bioimaging Group (NanoBIG) Instituto Ramón y Cajal de Investigación Sanitaria IRYCIS Ctra. Colmenar km. 9.100 Madrid 28034 SpainDepartamento de Química en Ciencias Farmacéuticas ‐ Facultad de Farmacia Universidad Complutense de Madrid Plaza Ramón y Cajal S/N Madrid 28040 SpainIMDEA Nanociencia Ciudad Universitaria de Cantoblanco Faraday 9 Madrid 28049 SpainIMDEA Nanociencia Ciudad Universitaria de Cantoblanco Faraday 9 Madrid 28049 SpainNanomaterials for Bioimaging Group (NanoBIG) Departamento de Fisiología ‐ Facultad de Medicina Universidad Autónoma de Madrid Arzobispo Morcillo 2 Madrid 28029 SpainDepartamento de Óptica, Facultad de Óptica y Optometría Universidad Complutense de Madrid Arcos de Jalon 118 Madrid 28037 SpainNanomaterials for Bioimaging Group (NanoBIG) Departamento de Fisiología ‐ Facultad de Medicina Universidad Autónoma de Madrid Arzobispo Morcillo 2 Madrid 28029 SpainDepartamento de Química en Ciencias Farmacéuticas ‐ Facultad de Farmacia Universidad Complutense de Madrid Plaza Ramón y Cajal S/N Madrid 28040 SpainNanomaterials for Bioimaging Group (NanoBIG) Instituto Ramón y Cajal de Investigación Sanitaria IRYCIS Ctra. Colmenar km. 9.100 Madrid 28034 SpainNanomaterials for Bioimaging Group (NanoBIG) Instituto Ramón y Cajal de Investigación Sanitaria IRYCIS Ctra. Colmenar km. 9.100 Madrid 28034 SpainAbstract Luminescent nano‐thermometry is a fast‐developing technique with great potential for in vivo sensing, diagnosis, and therapy. Unfortunately, it presents serious limitations. The luminescence generated by nanothermometers, from which thermal readout is obtained, is strongly distorted by the attenuation induced by tissues. Such distortions lead to low signal levels and entangle absolute and reliable thermal monitoring of internal organs. Overcoming both limitations requires the use of high‐brightness luminescent nanothermometers and adopting more complex approaches for temperature estimation. In this work, it is demonstrated how superbright Ag2S nanothermometers can provide in vivo, reliable, and absolute thermal reading of the liver during laser‐induced hyperthermia. For that, a new procedure is designed in which thermal readout is obtained from the combination of in vivo transient thermometry measurements and in silico simulations. The synergy between in vivo and in silico measurements has made it possible to assess relevant numbers such as the efficiency of hyperthermia processes, the total heat energy deposited in the liver, and the relative contribution of Ag2S nanoparticles to liver heating. This work provides a new way for absolute thermal sensing of internal organs with potential application not only to hyperthermia processes but also to advanced diagnosis and therapy.https://doi.org/10.1002/advs.202003838deep tissueliverluminescencenanoparticlesnano‐thermometry |
| spellingShingle | José Lifante Yingli Shen Irene Zabala Gutierrez Irene Rubia‐Rodríguez Daniel Ortega Nuria Fernandez Sonia Melle Miriam Granado Jorge Rubio‐Retama Daniel Jaque Erving Ximendes Reaching Deeper: Absolute In Vivo Thermal Reading of Liver by Combining Superbright Ag2S Nanothermometers and In Silico Simulations Advanced Science deep tissue liver luminescence nanoparticles nano‐thermometry |
| title | Reaching Deeper: Absolute In Vivo Thermal Reading of Liver by Combining Superbright Ag2S Nanothermometers and In Silico Simulations |
| title_full | Reaching Deeper: Absolute In Vivo Thermal Reading of Liver by Combining Superbright Ag2S Nanothermometers and In Silico Simulations |
| title_fullStr | Reaching Deeper: Absolute In Vivo Thermal Reading of Liver by Combining Superbright Ag2S Nanothermometers and In Silico Simulations |
| title_full_unstemmed | Reaching Deeper: Absolute In Vivo Thermal Reading of Liver by Combining Superbright Ag2S Nanothermometers and In Silico Simulations |
| title_short | Reaching Deeper: Absolute In Vivo Thermal Reading of Liver by Combining Superbright Ag2S Nanothermometers and In Silico Simulations |
| title_sort | reaching deeper absolute in vivo thermal reading of liver by combining superbright ag2s nanothermometers and in silico simulations |
| topic | deep tissue liver luminescence nanoparticles nano‐thermometry |
| url | https://doi.org/10.1002/advs.202003838 |
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