The Uso1 globular head interacts with SNAREs to maintain viability even in the absence of the coiled-coil domain

The Uso1 globular head interacts with SNAREs to maintain viability even in the absence of the coiled-coil domain

Uso1/p115 and RAB1 tether ER-derived vesicles to the Golgi. Uso1/p115 contains a globular-head-domain (GHD), a coiled-coil (CC) mediating dimerization/tethering, and a C-terminal region (CTR) interacting with golgins. Uso1/p115 is recruited to vesicles by RAB1. Genetic studies placed Uso1 paradoxica...

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Bibliographic Details
Main Authors: Ignacio Bravo-Plaza, Victor G Tagua, Herbert N Arst, Ana Alonso, Mario Pinar, Begoña Monterroso, Antonio Galindo, Miguel A Peñalva
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-05-01
Series:eLife
Subjects:
Aspergillus nidulans
tethering
SNAREs
RAB1
Online Access:https://elifesciences.org/articles/85079

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