Postmortem Süreçte COVID-19 Enfeksiyon Etkeninin Pozitif Kalma Süresi
Objective:Studies show that in patients diagnosed with Coronavirus disease-2019 (COVID-19), polymerase chain reaction (PCR) tests can give false negative results depending on sampling techniques/regions. In this study; the positivity of virus RNA was studied consecutive lung tru-cut needle biopsy ta...
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| Format: | Article |
| Language: | English |
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Adli Tıp Uzmanları Derneği
2023-12-01
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| Series: | Adli Tıp Bülteni |
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http://adlitipbulteni.com/archives/archive-detail/article-preview/postmortem-srete-covd-19-enfeksiyon-etkeninin-pozi/63670
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| author | Ümit Ünüvar Göçeoğlu Yasemin Balcı Turhan Togan Alper Aksözek Canan Gürsoy Burak Ekrem Çitil Yeşim Gök Çatal Ecesu Ekinci |
| author_facet | Ümit Ünüvar Göçeoğlu Yasemin Balcı Turhan Togan Alper Aksözek Canan Gürsoy Burak Ekrem Çitil Yeşim Gök Çatal Ecesu Ekinci |
| author_sort | Ümit Ünüvar Göçeoğlu |
| collection | DOAJ |
| description | Objective:Studies show that in patients diagnosed with Coronavirus disease-2019 (COVID-19), polymerase chain reaction (PCR) tests can give false negative results depending on sampling techniques/regions. In this study; the positivity of virus RNA was studied consecutive lung tru-cut needle biopsy taken at 6-hour intervals in cases who died during treatment due to COVID-19 infection, it was aimed to determine the postmortem safe working range.Methods:In May 2020-April 2021, 21 patients who died during treatment due to COVID-19 infection diagnosed with clinical and/or RNA detection in Muğla Training Research Hospital, Anesthesia Intensive Care Unit were included. Antemortem, postmortem swabs results, and virus RNA detection by PCR made from postmortem lung tissue samples were compared with their clinics. Statistical analysis was performed.Results:Fifteen (71.4%) of 21 cases were male and 6 (28.6%) were female. The mean age is 71.9 (standard deviation=12.079). All of the toracic CT findings at hospitalization had a ground-glass opacity. The mean hospitalization time was 11.7 days. Antemortem nasopharyngeal virus positivity was shown in 13 cases (61.9%), postmortem nasopharyngeal virus positivity in 5 cases (23.8%), and virus positivity in lung tissue samples in 7 cases (33.3%). No significant correlation was found virus positivity in nasopharyngeal swab and lung tissue sample, the incompatibility rate was 19.1%, which was statistically significant.Conclusion:Although the targeted sample size could not be reached due to study limitations, the inconsistency in virus positivity in nasopharyngeal swabs and lung tissue samples is significant. It is certain that studies with a large comparative sample are needed in terms of postmortem survival time, clinical and organ damage caused by the virus. |
| first_indexed | 2024-03-09T10:44:13Z |
| format | Article |
| id | doaj.art-23e025d5fe724d848a7ce633efd0ee57 |
| institution | Directory Open Access Journal |
| issn | 1300-865X 2149-4533 |
| language | English |
| last_indexed | 2024-03-09T10:44:13Z |
| publishDate | 2023-12-01 |
| publisher | Adli Tıp Uzmanları Derneği |
| record_format | Article |
| series | Adli Tıp Bülteni |
| spelling | doaj.art-23e025d5fe724d848a7ce633efd0ee572023-12-01T11:20:23ZengAdli Tıp Uzmanları DerneğiAdli Tıp Bülteni1300-865X2149-45332023-12-0128323924710.17986/blm.167113049054Postmortem Süreçte COVID-19 Enfeksiyon Etkeninin Pozitif Kalma SüresiÜmit Ünüvar Göçeoğlu0Yasemin Balcı1Turhan Togan2Alper Aksözek3Canan Gürsoy4Burak Ekrem Çitil5Yeşim Gök Çatal6Ecesu Ekinci7 Muğla Sıtkı Koçman Üniversitesi Tıp Fakültesi, Adli Tıp Anabilim Dalı, Muğla, Türkiye Muğla Sıtkı Koçman Üniversitesi Tıp Fakültesi, Adli Tıp Anabilim Dalı, Muğla, Türkiye Muğla Sıtkı Koçman Üniversitesi Tıp Fakültesi, Enfeksiyon Hastalıkları Anabilim Dalı, Muğla, Türkiye Muğla Sıtkı Koçman Üniversitesi Tıp Fakültesi, Anesteziyoloji ve Reanimasyon Anabilim Dalı, Yoğun Bakım Bilim Dalı, Muğla, Türkiye Muğla Sıtkı Koçman Üniversitesi Tıp Fakültesi, Tıbbi Mikrobiyoloji Anabilim Dalı, Muğla, Türkiye Muğla Sıtkı Koçman Üniversitesi Tıp Fakültesi, Anesteziyoloji ve Reanimasyon Anabilim Dalı, Yoğun Bakım Bilim Dalı, Muğla, Türkiye Adli Tıp Kurumu, Bodrum Adli Tıp Şube Müdürlüğü, Muğla, Türkiye Muğla Sıtkı Koçman Üniversitesi Tıp Fakültesi, Adli Tıp Anabilim Dalı, Muğla, Türkiye Objective:Studies show that in patients diagnosed with Coronavirus disease-2019 (COVID-19), polymerase chain reaction (PCR) tests can give false negative results depending on sampling techniques/regions. In this study; the positivity of virus RNA was studied consecutive lung tru-cut needle biopsy taken at 6-hour intervals in cases who died during treatment due to COVID-19 infection, it was aimed to determine the postmortem safe working range.Methods:In May 2020-April 2021, 21 patients who died during treatment due to COVID-19 infection diagnosed with clinical and/or RNA detection in Muğla Training Research Hospital, Anesthesia Intensive Care Unit were included. Antemortem, postmortem swabs results, and virus RNA detection by PCR made from postmortem lung tissue samples were compared with their clinics. Statistical analysis was performed.Results:Fifteen (71.4%) of 21 cases were male and 6 (28.6%) were female. The mean age is 71.9 (standard deviation=12.079). All of the toracic CT findings at hospitalization had a ground-glass opacity. The mean hospitalization time was 11.7 days. Antemortem nasopharyngeal virus positivity was shown in 13 cases (61.9%), postmortem nasopharyngeal virus positivity in 5 cases (23.8%), and virus positivity in lung tissue samples in 7 cases (33.3%). No significant correlation was found virus positivity in nasopharyngeal swab and lung tissue sample, the incompatibility rate was 19.1%, which was statistically significant.Conclusion:Although the targeted sample size could not be reached due to study limitations, the inconsistency in virus positivity in nasopharyngeal swabs and lung tissue samples is significant. It is certain that studies with a large comparative sample are needed in terms of postmortem survival time, clinical and organ damage caused by the virus. http://adlitipbulteni.com/archives/archive-detail/article-preview/postmortem-srete-covd-19-enfeksiyon-etkeninin-pozi/63670 covid-19sars-cov-2swab sampletissue samplepcrpostmortem |
| spellingShingle | Ümit Ünüvar Göçeoğlu Yasemin Balcı Turhan Togan Alper Aksözek Canan Gürsoy Burak Ekrem Çitil Yeşim Gök Çatal Ecesu Ekinci Postmortem Süreçte COVID-19 Enfeksiyon Etkeninin Pozitif Kalma Süresi Adli Tıp Bülteni covid-19 sars-cov-2 swab sample tissue sample pcr postmortem |
| title | Postmortem Süreçte COVID-19 Enfeksiyon Etkeninin Pozitif Kalma Süresi |
| title_full | Postmortem Süreçte COVID-19 Enfeksiyon Etkeninin Pozitif Kalma Süresi |
| title_fullStr | Postmortem Süreçte COVID-19 Enfeksiyon Etkeninin Pozitif Kalma Süresi |
| title_full_unstemmed | Postmortem Süreçte COVID-19 Enfeksiyon Etkeninin Pozitif Kalma Süresi |
| title_short | Postmortem Süreçte COVID-19 Enfeksiyon Etkeninin Pozitif Kalma Süresi |
| title_sort | postmortem surecte covid 19 enfeksiyon etkeninin pozitif kalma suresi |
| topic | covid-19 sars-cov-2 swab sample tissue sample pcr postmortem |
| url |
http://adlitipbulteni.com/archives/archive-detail/article-preview/postmortem-srete-covd-19-enfeksiyon-etkeninin-pozi/63670
|
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