After In Vitro Digestion, Jackfruit Flake Affords Protection against Acrylamide-Induced Oxidative Damage
Some studies have demonstrated that acrylamide (AA) was correlated with oxidative stress, resulting in physical damage. The jackfruit flake was an immature pulp that contained a high level of antioxidant activity. This study aimed to assess the defensive efficacy of jackfruit flake in AA-induced oxi...
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MDPI AG
2019-09-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/24/18/3322 |
| _version_ | 1818945373927899136 |
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| author | Daofeng Qu Chu Liu Mengxue Jiang Lifang Feng Yuewen Chen Jianzhong Han |
| author_facet | Daofeng Qu Chu Liu Mengxue Jiang Lifang Feng Yuewen Chen Jianzhong Han |
| author_sort | Daofeng Qu |
| collection | DOAJ |
| description | Some studies have demonstrated that acrylamide (AA) was correlated with oxidative stress, resulting in physical damage. The jackfruit flake was an immature pulp that contained a high level of antioxidant activity. This study aimed to assess the defensive efficacy of jackfruit flake in AA-induced oxidative stress before and after simulated gastrointestinal digestion. Our results indicate that the total polyphenol content of Jackfruit flake digest (Digestive products of jackfruit flake after gastrointestinal, JFG) was diminished; however, JFG had raised the relative antioxidant capacity compared to Jackfruit flake extract (JFE). Additionally, the results of High Performance Liquid Chromatography-Mass Spectrometry (HPLC-MS) implied that a proportion of compounds were degraded/converted into other unknown and/or undetected metabolites. Further, by high content analysis (HCA) techniques, JFG markedly reduced cytotoxicity and excessive production of reactive oxygen species (ROS) in cells, thereby alleviating mitochondrial disorders. In this study, it may be converted active compounds after digestion that had preferable protective effects against AA-induced oxidative damage. |
| first_indexed | 2024-12-20T07:58:06Z |
| format | Article |
| id | doaj.art-23e0f5d8429e4e67b637520b4175a3eb |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-20T07:58:06Z |
| publishDate | 2019-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-23e0f5d8429e4e67b637520b4175a3eb2022-12-21T19:47:35ZengMDPI AGMolecules1420-30492019-09-012418332210.3390/molecules24183322molecules24183322After In Vitro Digestion, Jackfruit Flake Affords Protection against Acrylamide-Induced Oxidative DamageDaofeng Qu0Chu Liu1Mengxue Jiang2Lifang Feng3Yuewen Chen4Jianzhong Han5School of food science and biotechnology, Zhejiang Gongshang University, Hangzhou 310018, ChinaSchool of food science and biotechnology, Zhejiang Gongshang University, Hangzhou 310018, ChinaSchool of food science and biotechnology, Zhejiang Gongshang University, Hangzhou 310018, ChinaSchool of food science and biotechnology, Zhejiang Gongshang University, Hangzhou 310018, ChinaSchool of food science and biotechnology, Zhejiang Gongshang University, Hangzhou 310018, ChinaSchool of food science and biotechnology, Zhejiang Gongshang University, Hangzhou 310018, ChinaSome studies have demonstrated that acrylamide (AA) was correlated with oxidative stress, resulting in physical damage. The jackfruit flake was an immature pulp that contained a high level of antioxidant activity. This study aimed to assess the defensive efficacy of jackfruit flake in AA-induced oxidative stress before and after simulated gastrointestinal digestion. Our results indicate that the total polyphenol content of Jackfruit flake digest (Digestive products of jackfruit flake after gastrointestinal, JFG) was diminished; however, JFG had raised the relative antioxidant capacity compared to Jackfruit flake extract (JFE). Additionally, the results of High Performance Liquid Chromatography-Mass Spectrometry (HPLC-MS) implied that a proportion of compounds were degraded/converted into other unknown and/or undetected metabolites. Further, by high content analysis (HCA) techniques, JFG markedly reduced cytotoxicity and excessive production of reactive oxygen species (ROS) in cells, thereby alleviating mitochondrial disorders. In this study, it may be converted active compounds after digestion that had preferable protective effects against AA-induced oxidative damage.https://www.mdpi.com/1420-3049/24/18/3322jackfruit flakein vitro digestionpolyphenoloxidative stresshigh-content analysis |
| spellingShingle | Daofeng Qu Chu Liu Mengxue Jiang Lifang Feng Yuewen Chen Jianzhong Han After In Vitro Digestion, Jackfruit Flake Affords Protection against Acrylamide-Induced Oxidative Damage Molecules jackfruit flake in vitro digestion polyphenol oxidative stress high-content analysis |
| title | After In Vitro Digestion, Jackfruit Flake Affords Protection against Acrylamide-Induced Oxidative Damage |
| title_full | After In Vitro Digestion, Jackfruit Flake Affords Protection against Acrylamide-Induced Oxidative Damage |
| title_fullStr | After In Vitro Digestion, Jackfruit Flake Affords Protection against Acrylamide-Induced Oxidative Damage |
| title_full_unstemmed | After In Vitro Digestion, Jackfruit Flake Affords Protection against Acrylamide-Induced Oxidative Damage |
| title_short | After In Vitro Digestion, Jackfruit Flake Affords Protection against Acrylamide-Induced Oxidative Damage |
| title_sort | after in vitro digestion jackfruit flake affords protection against acrylamide induced oxidative damage |
| topic | jackfruit flake in vitro digestion polyphenol oxidative stress high-content analysis |
| url | https://www.mdpi.com/1420-3049/24/18/3322 |
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