Survival and failure types after radiation therapy of vulvar cancer
Background and purpose: Describe the survival rates and distribution of events on competing failure types in vulvar carcinoma after treatment with chemoradiation (CRT) or radiation (RT) alone. Material and methods: We included patients with vulvar carcinoma treated with CRT or RT between 2009 and 20...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-08-01
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| Series: | Clinical and Translational Radiation Oncology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405630817300034 |
| _version_ | 1818741991020691456 |
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| author | Christina Steen Vorbeck Ivan Richter Vogelius Marie Louise Vorndran Cøln Banner-Voigt Hanne From Mathiesen Mansoor Raza Mirza |
| author_facet | Christina Steen Vorbeck Ivan Richter Vogelius Marie Louise Vorndran Cøln Banner-Voigt Hanne From Mathiesen Mansoor Raza Mirza |
| author_sort | Christina Steen Vorbeck |
| collection | DOAJ |
| description | Background and purpose: Describe the survival rates and distribution of events on competing failure types in vulvar carcinoma after treatment with chemoradiation (CRT) or radiation (RT) alone.
Material and methods: We included patients with vulvar carcinoma treated with CRT or RT between 2009 and 2014. Survival was estimated using the Kaplan-Meier method. We performed a competing risk analysis and included five competing events: loco-regional failure (LRF), distant metastasis, LRF plus distant metastasis, and death without evidence of disease, with the remaining patients denoted alive without evidence of disease.
Results: 87 patients were treated. Progression free survival (PFS) and overall survival (OS) at 3 years were 40% and 57%, respectively. 41.3% of patients relapsed, most often loco-regionally. We saw significantly worse PFS and OS for patients older than 68 (p = 0.011/p = 0.010) and for patients treated with definitive RT (p = 0.004/p = 0.005). Competing risk analysis showed increased risk of LRF, and that death was most often related to vulvar cancer. Death without disease recurrence was less frequent, even in the elderly.
Conclusions: LRF was the most common event. PFS and OS were inferior for elderly patients and patients treated definitively. A better understanding of these differences may be used to define risk adapted treatment strategies. |
| first_indexed | 2024-12-18T02:05:24Z |
| format | Article |
| id | doaj.art-23e22c8773ad43ad8958045f09ec9fee |
| institution | Directory Open Access Journal |
| issn | 2405-6308 |
| language | English |
| last_indexed | 2024-12-18T02:05:24Z |
| publishDate | 2017-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Clinical and Translational Radiation Oncology |
| spelling | doaj.art-23e22c8773ad43ad8958045f09ec9fee2022-12-21T21:24:36ZengElsevierClinical and Translational Radiation Oncology2405-63082017-08-015C202710.1016/j.ctro.2017.06.002Survival and failure types after radiation therapy of vulvar cancerChristina Steen VorbeckIvan Richter VogeliusMarie Louise Vorndran Cøln Banner-VoigtHanne From MathiesenMansoor Raza MirzaBackground and purpose: Describe the survival rates and distribution of events on competing failure types in vulvar carcinoma after treatment with chemoradiation (CRT) or radiation (RT) alone. Material and methods: We included patients with vulvar carcinoma treated with CRT or RT between 2009 and 2014. Survival was estimated using the Kaplan-Meier method. We performed a competing risk analysis and included five competing events: loco-regional failure (LRF), distant metastasis, LRF plus distant metastasis, and death without evidence of disease, with the remaining patients denoted alive without evidence of disease. Results: 87 patients were treated. Progression free survival (PFS) and overall survival (OS) at 3 years were 40% and 57%, respectively. 41.3% of patients relapsed, most often loco-regionally. We saw significantly worse PFS and OS for patients older than 68 (p = 0.011/p = 0.010) and for patients treated with definitive RT (p = 0.004/p = 0.005). Competing risk analysis showed increased risk of LRF, and that death was most often related to vulvar cancer. Death without disease recurrence was less frequent, even in the elderly. Conclusions: LRF was the most common event. PFS and OS were inferior for elderly patients and patients treated definitively. A better understanding of these differences may be used to define risk adapted treatment strategies.http://www.sciencedirect.com/science/article/pii/S2405630817300034Vulvar cancerChemoradiationRadiationFailure typesElderly |
| spellingShingle | Christina Steen Vorbeck Ivan Richter Vogelius Marie Louise Vorndran Cøln Banner-Voigt Hanne From Mathiesen Mansoor Raza Mirza Survival and failure types after radiation therapy of vulvar cancer Clinical and Translational Radiation Oncology Vulvar cancer Chemoradiation Radiation Failure types Elderly |
| title | Survival and failure types after radiation therapy of vulvar cancer |
| title_full | Survival and failure types after radiation therapy of vulvar cancer |
| title_fullStr | Survival and failure types after radiation therapy of vulvar cancer |
| title_full_unstemmed | Survival and failure types after radiation therapy of vulvar cancer |
| title_short | Survival and failure types after radiation therapy of vulvar cancer |
| title_sort | survival and failure types after radiation therapy of vulvar cancer |
| topic | Vulvar cancer Chemoradiation Radiation Failure types Elderly |
| url | http://www.sciencedirect.com/science/article/pii/S2405630817300034 |
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