Epitope mapping of monoclonal antibodies: a comprehensive comparison of different technologies

Epitope mapping of monoclonal antibodies: a comprehensive comparison of different technologies

ABSTRACTMonoclonal antibodies have become an important class of therapeutics in the last 30 years. Because the mechanism of action of therapeutic antibodies is intimately linked to their binding epitopes, identification of the epitope of an antibody to the antigen plays a central role during antibod...

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Bibliographic Details
Main Authors: Xibei Dang, Lars Guelen, David Lutje Hulsik, Grigori Ermakov, Edward J. Hsieh, Joost Kreijtz, Judith Stammen-Vogelzangs, Imke Lodewijks, Astrid Bertens, Arne Bramer, Marco Guadagnoli, Alexis Nazabal, Andrea van Elsas, Thierry Fischmann, Veronica Juan, Amy Beebe, Maribel Beaumont, Hans van Eenennaam
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:mAbs
Subjects:
Alanine scan
cross-linking
Epitope mapping
Hydrogen deuterium exchange
hydroxyl radical footprinting
monoclonal antibodies
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2023.2285285

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