Good Long-Term Prognosis of Lupus Nephritis in the High-Income Afro-Caribbean Population of Martinique with Free Access to Healthcare
Lupus nephritis (LN) has been described as having worse survival and renal outcomes in African-descent patients than Caucasians. We aimed to provide long-term population-based data in an Afro-descendant cohort of LN with high income and easy and free access to specialized healthcare. Study design: W...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/16/4860 |
| _version_ | 1797444346229817344 |
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| author | Benoit Suzon Fabienne Louis-Sidney Cédric Aglaé Kim Henry Cécile Bagoée Sophie Wolff Florence Moinet Violaine Emal-Aglaé Katlyne Polomat Michel DeBandt Christophe Deligny Aymeric Couturier |
| author_facet | Benoit Suzon Fabienne Louis-Sidney Cédric Aglaé Kim Henry Cécile Bagoée Sophie Wolff Florence Moinet Violaine Emal-Aglaé Katlyne Polomat Michel DeBandt Christophe Deligny Aymeric Couturier |
| author_sort | Benoit Suzon |
| collection | DOAJ |
| description | Lupus nephritis (LN) has been described as having worse survival and renal outcomes in African-descent patients than Caucasians. We aimed to provide long-term population-based data in an Afro-descendant cohort of LN with high income and easy and free access to specialized healthcare. Study design: We performed a retrospective population-based analysis using data from 2002–2015 of 1140 renal biopsies at the University Hospital of Martinique (French West Indies). All systemic lupus erythematosus patients with a diagnosis of LN followed for at least 12 months in Martinique or who died during this period were included. Results: A total of 89 patients were included, of whom 68 (76.4%) had proliferative (class III or IV), 17 (19.1%) had membranous (class V), and 4 (4.5%) had class I or II lupus nephritis according to the ISN/RPS classification. At a mean follow-up of 118.3 months, 51.7% of patients were still in remission. The rates of end-stage renal disease were 13.5%, 19.1%, and 21.3% at 10, 15, and 20 years of follow-up, respectively, and mortality rates were 4.5%, 5.6%, and 7.9% at 10, 15, and 20 years of follow-up, respectively. Conclusions: The good survival of our Afro-descendant LN patients, similar to that observed in Caucasians, shades the burden of ethnicity but rather emphasizes and reinforces the importance of optimizing all modifiable factors associated with poor outcome, especially socioeconomics. |
| first_indexed | 2024-03-09T13:11:20Z |
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| id | doaj.art-23e342863a3b4c8f80bfd642649c9ffb |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T13:11:20Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-23e342863a3b4c8f80bfd642649c9ffb2023-11-30T21:41:47ZengMDPI AGJournal of Clinical Medicine2077-03832022-08-011116486010.3390/jcm11164860Good Long-Term Prognosis of Lupus Nephritis in the High-Income Afro-Caribbean Population of Martinique with Free Access to HealthcareBenoit Suzon0Fabienne Louis-Sidney1Cédric Aglaé2Kim Henry3Cécile Bagoée4Sophie Wolff5Florence Moinet6Violaine Emal-Aglaé7Katlyne Polomat8Michel DeBandt9Christophe Deligny10Aymeric Couturier11Department of Internal Medicine, Martinique University Hospital, CEDEX CS, 90632 Fort-de-France, Martinique, FranceDepartment of Rheumatology, Martinique University Hospital, CEDEX CS, 90632 Fort-de-France, Martinique, FranceDepartment of Nephrology, Martinique University Hospital, CEDEX CS, 90632 Fort-de-France, Martinique, FranceDepartment of Internal Medicine, Martinique University Hospital, CEDEX CS, 90632 Fort-de-France, Martinique, FranceDepartment of Internal Medicine, Martinique University Hospital, CEDEX CS, 90632 Fort-de-France, Martinique, FranceDepartment of Internal Medicine, Martinique University Hospital, CEDEX CS, 90632 Fort-de-France, Martinique, FranceDepartment of Internal Medicine, Martinique University Hospital, CEDEX CS, 90632 Fort-de-France, Martinique, FranceDepartment of Nephrology, Martinique University Hospital, CEDEX CS, 90632 Fort-de-France, Martinique, FranceDepartment of Internal Medicine, Martinique University Hospital, CEDEX CS, 90632 Fort-de-France, Martinique, FranceDepartment of Rheumatology, Martinique University Hospital, CEDEX CS, 90632 Fort-de-France, Martinique, FranceDepartment of Internal Medicine, Martinique University Hospital, CEDEX CS, 90632 Fort-de-France, Martinique, FranceDepartment of Internal Medicine, Martinique University Hospital, CEDEX CS, 90632 Fort-de-France, Martinique, FranceLupus nephritis (LN) has been described as having worse survival and renal outcomes in African-descent patients than Caucasians. We aimed to provide long-term population-based data in an Afro-descendant cohort of LN with high income and easy and free access to specialized healthcare. Study design: We performed a retrospective population-based analysis using data from 2002–2015 of 1140 renal biopsies at the University Hospital of Martinique (French West Indies). All systemic lupus erythematosus patients with a diagnosis of LN followed for at least 12 months in Martinique or who died during this period were included. Results: A total of 89 patients were included, of whom 68 (76.4%) had proliferative (class III or IV), 17 (19.1%) had membranous (class V), and 4 (4.5%) had class I or II lupus nephritis according to the ISN/RPS classification. At a mean follow-up of 118.3 months, 51.7% of patients were still in remission. The rates of end-stage renal disease were 13.5%, 19.1%, and 21.3% at 10, 15, and 20 years of follow-up, respectively, and mortality rates were 4.5%, 5.6%, and 7.9% at 10, 15, and 20 years of follow-up, respectively. Conclusions: The good survival of our Afro-descendant LN patients, similar to that observed in Caucasians, shades the burden of ethnicity but rather emphasizes and reinforces the importance of optimizing all modifiable factors associated with poor outcome, especially socioeconomics.https://www.mdpi.com/2077-0383/11/16/4860Afro-Caribbeansystemic lupuslupus nephritislong-term prognosisend-stage renal diseasemortality |
| spellingShingle | Benoit Suzon Fabienne Louis-Sidney Cédric Aglaé Kim Henry Cécile Bagoée Sophie Wolff Florence Moinet Violaine Emal-Aglaé Katlyne Polomat Michel DeBandt Christophe Deligny Aymeric Couturier Good Long-Term Prognosis of Lupus Nephritis in the High-Income Afro-Caribbean Population of Martinique with Free Access to Healthcare Journal of Clinical Medicine Afro-Caribbean systemic lupus lupus nephritis long-term prognosis end-stage renal disease mortality |
| title | Good Long-Term Prognosis of Lupus Nephritis in the High-Income Afro-Caribbean Population of Martinique with Free Access to Healthcare |
| title_full | Good Long-Term Prognosis of Lupus Nephritis in the High-Income Afro-Caribbean Population of Martinique with Free Access to Healthcare |
| title_fullStr | Good Long-Term Prognosis of Lupus Nephritis in the High-Income Afro-Caribbean Population of Martinique with Free Access to Healthcare |
| title_full_unstemmed | Good Long-Term Prognosis of Lupus Nephritis in the High-Income Afro-Caribbean Population of Martinique with Free Access to Healthcare |
| title_short | Good Long-Term Prognosis of Lupus Nephritis in the High-Income Afro-Caribbean Population of Martinique with Free Access to Healthcare |
| title_sort | good long term prognosis of lupus nephritis in the high income afro caribbean population of martinique with free access to healthcare |
| topic | Afro-Caribbean systemic lupus lupus nephritis long-term prognosis end-stage renal disease mortality |
| url | https://www.mdpi.com/2077-0383/11/16/4860 |
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