A Prospective Italian Study on Baseline NS3 and NS5A Resistance to Direct-Acting Antivirals in a Real-World Setting of HIV-1/HCV Coinfected Patients and Association with Treatment Outcome
We prospectively evaluated the frequency of natural resistance-associated substitutions (RASs) in the NS3 and NS5A regions according to different HCV genotypes and their possible effect on treatment outcome in HIV-1/HCV patients treated with direct-acting antivirals (DAAs). Baseline RASs in the NS3...
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MDPI AG
2020-02-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/12/3/269 |
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| author | Sabrina Bagaglio Hamid Hasson Luca Peano Riccardo Vercesi Emanuela Messina Andrea Galli Caterina Uberti Foppa Giulia Morsica |
| author_facet | Sabrina Bagaglio Hamid Hasson Luca Peano Riccardo Vercesi Emanuela Messina Andrea Galli Caterina Uberti Foppa Giulia Morsica |
| author_sort | Sabrina Bagaglio |
| collection | DOAJ |
| description | We prospectively evaluated the frequency of natural resistance-associated substitutions (RASs) in the NS3 and NS5A regions according to different HCV genotypes and their possible effect on treatment outcome in HIV-1/HCV patients treated with direct-acting antivirals (DAAs). Baseline RASs in the NS3 and NS5A domains were investigated in 62 HIV-1/HCV patients treated with DAAs: 23 patients harbored HCV-GT1a, 26 harbored GT3a, and 13 harbored GT4d. A higher occurrence of RASs was found in the NS3 domain within GT1a (13/23) than GT3a (0/26) or GT4d (2/13). With regard to treatment outcome, NS3 RASs were detected in 14/56 patients with sustained virological response (SVR) and in 1/6 non-responder (NR) patients. Occurrence of RASs of NS5A domain was lower in SVR (4/56, had RASs) than in NR (3/6, had RASs). Evaluation of RASs at baseline instead of at virological failure, especially in the NS5A domain, could positively influence the choice of new DAA combinations for the treatment of HIV-1/HCV patients. |
| first_indexed | 2024-04-12T20:06:40Z |
| format | Article |
| id | doaj.art-23e3b4e6dbc04f2f8efe360bf5f7f02f |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-04-12T20:06:40Z |
| publishDate | 2020-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-23e3b4e6dbc04f2f8efe360bf5f7f02f2022-12-22T03:18:22ZengMDPI AGViruses1999-49152020-02-0112326910.3390/v12030269v12030269A Prospective Italian Study on Baseline NS3 and NS5A Resistance to Direct-Acting Antivirals in a Real-World Setting of HIV-1/HCV Coinfected Patients and Association with Treatment OutcomeSabrina Bagaglio0Hamid Hasson1Luca Peano2Riccardo Vercesi3Emanuela Messina4Andrea Galli5Caterina Uberti Foppa6Giulia Morsica7Division of Infectious Diseases, IRCCS, Ospedale San Raffaele, 20132 Milan, ItalyDivision of Infectious Diseases, IRCCS, Ospedale San Raffaele, 20132 Milan, ItalyOrdine dei Medici della Valle d’Aosta, 11100 Aosta, ItalyDivision of Infectious Diseases, IRCCS, Ospedale San Raffaele, 20132 Milan, ItalyDivision of Infectious Diseases, IRCCS, Ospedale San Raffaele, 20132 Milan, ItalyDivision of Infectious Diseases, IRCCS, Ospedale San Raffaele, 20132 Milan, ItalyVita-Salute San Raffaele University, 20132 Milan, ItalyDivision of Infectious Diseases, IRCCS, Ospedale San Raffaele, 20132 Milan, ItalyWe prospectively evaluated the frequency of natural resistance-associated substitutions (RASs) in the NS3 and NS5A regions according to different HCV genotypes and their possible effect on treatment outcome in HIV-1/HCV patients treated with direct-acting antivirals (DAAs). Baseline RASs in the NS3 and NS5A domains were investigated in 62 HIV-1/HCV patients treated with DAAs: 23 patients harbored HCV-GT1a, 26 harbored GT3a, and 13 harbored GT4d. A higher occurrence of RASs was found in the NS3 domain within GT1a (13/23) than GT3a (0/26) or GT4d (2/13). With regard to treatment outcome, NS3 RASs were detected in 14/56 patients with sustained virological response (SVR) and in 1/6 non-responder (NR) patients. Occurrence of RASs of NS5A domain was lower in SVR (4/56, had RASs) than in NR (3/6, had RASs). Evaluation of RASs at baseline instead of at virological failure, especially in the NS5A domain, could positively influence the choice of new DAA combinations for the treatment of HIV-1/HCV patients.https://www.mdpi.com/1999-4915/12/3/269hcv resistancegenotypehiv-1direct acting antivirals |
| spellingShingle | Sabrina Bagaglio Hamid Hasson Luca Peano Riccardo Vercesi Emanuela Messina Andrea Galli Caterina Uberti Foppa Giulia Morsica A Prospective Italian Study on Baseline NS3 and NS5A Resistance to Direct-Acting Antivirals in a Real-World Setting of HIV-1/HCV Coinfected Patients and Association with Treatment Outcome Viruses hcv resistance genotype hiv-1 direct acting antivirals |
| title | A Prospective Italian Study on Baseline NS3 and NS5A Resistance to Direct-Acting Antivirals in a Real-World Setting of HIV-1/HCV Coinfected Patients and Association with Treatment Outcome |
| title_full | A Prospective Italian Study on Baseline NS3 and NS5A Resistance to Direct-Acting Antivirals in a Real-World Setting of HIV-1/HCV Coinfected Patients and Association with Treatment Outcome |
| title_fullStr | A Prospective Italian Study on Baseline NS3 and NS5A Resistance to Direct-Acting Antivirals in a Real-World Setting of HIV-1/HCV Coinfected Patients and Association with Treatment Outcome |
| title_full_unstemmed | A Prospective Italian Study on Baseline NS3 and NS5A Resistance to Direct-Acting Antivirals in a Real-World Setting of HIV-1/HCV Coinfected Patients and Association with Treatment Outcome |
| title_short | A Prospective Italian Study on Baseline NS3 and NS5A Resistance to Direct-Acting Antivirals in a Real-World Setting of HIV-1/HCV Coinfected Patients and Association with Treatment Outcome |
| title_sort | prospective italian study on baseline ns3 and ns5a resistance to direct acting antivirals in a real world setting of hiv 1 hcv coinfected patients and association with treatment outcome |
| topic | hcv resistance genotype hiv-1 direct acting antivirals |
| url | https://www.mdpi.com/1999-4915/12/3/269 |
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