A study of efficacy of Nigella sativa in treatment of Meniere's disease: A randomized, placebo controlled clinical trial
Purpose: Meniere's disease (MD), first introduced by Prosper Meniere, is characterized mainly by vertigo, tinnitus, aural fullness and sensorineural hearing loss. Though the exact pathophysiology of MD is unknown, immunologic and inflammatory interactions are possible underlying mechanisms invo...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-04-01
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| Series: | Journal of Otology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1672293023000132 |
| _version_ | 1797839031503945728 |
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| author | Masoud Motesadi Zarandi Zahra Rabbani Mahtab Rabbani Anari Ali Kouhi Mona Zeinaloo |
| author_facet | Masoud Motesadi Zarandi Zahra Rabbani Mahtab Rabbani Anari Ali Kouhi Mona Zeinaloo |
| author_sort | Masoud Motesadi Zarandi |
| collection | DOAJ |
| description | Purpose: Meniere's disease (MD), first introduced by Prosper Meniere, is characterized mainly by vertigo, tinnitus, aural fullness and sensorineural hearing loss. Though the exact pathophysiology of MD is unknown, immunologic and inflammatory interactions are possible underlying mechanisms involved in MD. This study is aimed to investigate the immunomodulatory and anti-inflammatory effect of Nigella sativa on MD as a therapeutic agent. Methods: We divided 40 patients with definite MD into two groups of 20 cases. The study group received 1 g of Nigella sativa oil daily for three months and the control group received a placebo. Changes in hearing, tinnitus and vertigo were estimated by pure tone audiometry, tinnitus handicap inventory questionnaire and dizziness handicap inventory questionnaire, respectively. Results: At the end of the study we did not observe any significant improvement in study's group hearing threshold, tinnitus and vertigo compared to the control group. Conclusions: In this study, statistical analysis showed that Nigella sativa failed to improve signs and symptoms of MD. However, further investigations with a larger study population are needed to ascertain the current conclusion. |
| first_indexed | 2024-04-09T15:51:41Z |
| format | Article |
| id | doaj.art-23e40e2c24b44ca68c74fe14df149e70 |
| institution | Directory Open Access Journal |
| issn | 1672-2930 |
| language | English |
| last_indexed | 2024-04-09T15:51:41Z |
| publishDate | 2023-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Otology |
| spelling | doaj.art-23e40e2c24b44ca68c74fe14df149e702023-04-26T05:56:07ZengElsevierJournal of Otology1672-29302023-04-0118297100A study of efficacy of Nigella sativa in treatment of Meniere's disease: A randomized, placebo controlled clinical trialMasoud Motesadi Zarandi0Zahra Rabbani1Mahtab Rabbani Anari2Ali Kouhi3Mona Zeinaloo4Department of Cochlear Implant and Otorhinolaryngology, Tehran University of Medical Sciences, Tehran, IranAmir Alam Hospital, Tehran University of Medical Sciences, Tehran, Iran; Corresponding author. E.N.T Department, Amiralam Hospital, Saadi Ave, Tehran, Iran.Otorhinolaryngology Research Center, Amir Alam Hospital, Tehran University of Medical Sciences, Tehran, IranOtorhinolaryngology Research Center, Tehran University of Medical Sciences, Tehran, Iran; Department of Otorhinolaryngology and Head and Neck Surgery, Amir Alam Hospital, Tehran University of Medical Sciences, Tehran, IranDepartment of Community Medicine, Tehran University of Medical Sciences, Tehran, IranPurpose: Meniere's disease (MD), first introduced by Prosper Meniere, is characterized mainly by vertigo, tinnitus, aural fullness and sensorineural hearing loss. Though the exact pathophysiology of MD is unknown, immunologic and inflammatory interactions are possible underlying mechanisms involved in MD. This study is aimed to investigate the immunomodulatory and anti-inflammatory effect of Nigella sativa on MD as a therapeutic agent. Methods: We divided 40 patients with definite MD into two groups of 20 cases. The study group received 1 g of Nigella sativa oil daily for three months and the control group received a placebo. Changes in hearing, tinnitus and vertigo were estimated by pure tone audiometry, tinnitus handicap inventory questionnaire and dizziness handicap inventory questionnaire, respectively. Results: At the end of the study we did not observe any significant improvement in study's group hearing threshold, tinnitus and vertigo compared to the control group. Conclusions: In this study, statistical analysis showed that Nigella sativa failed to improve signs and symptoms of MD. However, further investigations with a larger study population are needed to ascertain the current conclusion.http://www.sciencedirect.com/science/article/pii/S1672293023000132Meniere's diseaseNigella sativaTinnitusVertigoHearing loss |
| spellingShingle | Masoud Motesadi Zarandi Zahra Rabbani Mahtab Rabbani Anari Ali Kouhi Mona Zeinaloo A study of efficacy of Nigella sativa in treatment of Meniere's disease: A randomized, placebo controlled clinical trial Journal of Otology Meniere's disease Nigella sativa Tinnitus Vertigo Hearing loss |
| title | A study of efficacy of Nigella sativa in treatment of Meniere's disease: A randomized, placebo controlled clinical trial |
| title_full | A study of efficacy of Nigella sativa in treatment of Meniere's disease: A randomized, placebo controlled clinical trial |
| title_fullStr | A study of efficacy of Nigella sativa in treatment of Meniere's disease: A randomized, placebo controlled clinical trial |
| title_full_unstemmed | A study of efficacy of Nigella sativa in treatment of Meniere's disease: A randomized, placebo controlled clinical trial |
| title_short | A study of efficacy of Nigella sativa in treatment of Meniere's disease: A randomized, placebo controlled clinical trial |
| title_sort | study of efficacy of nigella sativa in treatment of meniere s disease a randomized placebo controlled clinical trial |
| topic | Meniere's disease Nigella sativa Tinnitus Vertigo Hearing loss |
| url | http://www.sciencedirect.com/science/article/pii/S1672293023000132 |
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