Differential conformational dynamics in two type-A RNA-binding domains drive the double-stranded RNA recognition and binding

Differential conformational dynamics in two type-A RNA-binding domains drive the double-stranded RNA recognition and binding

Trans-activation response (TAR) RNA-binding protein (TRBP) has emerged as a key player in the RNA interference pathway, wherein it binds to different pre-microRNAs (miRNAs) and small interfering RNAs (siRNAs), each varying in sequence and/or structure. We hypothesize that TRBP displays dynamic adapt...

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Hlavní autoři: Firdousi Parvez, Devika Sangpal, Harshad Paithankar, Zainab Amin, Jeetender Chugh
Médium: Článek
Jazyk:English
Vydáno: eLife Sciences Publications Ltd 2024-08-01
Edice:eLife
Témata:
RNA recognition
protein dynamics
conformational heterogeneity
MD simulation
On-line přístup:https://elifesciences.org/articles/94842

Internet

https://elifesciences.org/articles/94842

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