Colonic immune suppression, barrier dysfunction, and dysbiosis by gastrointestinal bacillus anthracis Infection.
Gastrointestinal (GI) anthrax results from the ingestion of Bacillus anthracis. Herein, we investigated the pathogenesis of GI anthrax in animals orally infected with toxigenic non-encapsulated B. anthracis Sterne strain (pXO1+ pXO2-) spores that resulted in rapid animal death. B. anthracis Sterne i...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4063899?pdf=render |
| _version_ | 1818358997423489024 |
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| author | Yaíma L Lightfoot Tao Yang Bikash Sahay Mojgan Zadeh Sam X Cheng Gary P Wang Jennifer L Owen Mansour Mohamadzadeh |
| author_facet | Yaíma L Lightfoot Tao Yang Bikash Sahay Mojgan Zadeh Sam X Cheng Gary P Wang Jennifer L Owen Mansour Mohamadzadeh |
| author_sort | Yaíma L Lightfoot |
| collection | DOAJ |
| description | Gastrointestinal (GI) anthrax results from the ingestion of Bacillus anthracis. Herein, we investigated the pathogenesis of GI anthrax in animals orally infected with toxigenic non-encapsulated B. anthracis Sterne strain (pXO1+ pXO2-) spores that resulted in rapid animal death. B. anthracis Sterne induced significant breakdown of intestinal barrier function and led to gut dysbiosis, resulting in systemic dissemination of not only B. anthracis, but also of commensals. Disease progression significantly correlated with the deterioration of innate and T cell functions. Our studies provide critical immunologic and physiologic insights into the pathogenesis of GI anthrax infection, whereupon cleavage of mitogen-activated protein kinases (MAPKs) in immune cells may play a central role in promoting dysfunctional immune responses against this deadly pathogen. |
| first_indexed | 2024-12-13T20:37:53Z |
| format | Article |
| id | doaj.art-23e5c5c2dc494cce92dbcb44ff5e8067 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T20:37:53Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-23e5c5c2dc494cce92dbcb44ff5e80672022-12-21T23:32:14ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0196e10053210.1371/journal.pone.0100532Colonic immune suppression, barrier dysfunction, and dysbiosis by gastrointestinal bacillus anthracis Infection.Yaíma L LightfootTao YangBikash SahayMojgan ZadehSam X ChengGary P WangJennifer L OwenMansour MohamadzadehGastrointestinal (GI) anthrax results from the ingestion of Bacillus anthracis. Herein, we investigated the pathogenesis of GI anthrax in animals orally infected with toxigenic non-encapsulated B. anthracis Sterne strain (pXO1+ pXO2-) spores that resulted in rapid animal death. B. anthracis Sterne induced significant breakdown of intestinal barrier function and led to gut dysbiosis, resulting in systemic dissemination of not only B. anthracis, but also of commensals. Disease progression significantly correlated with the deterioration of innate and T cell functions. Our studies provide critical immunologic and physiologic insights into the pathogenesis of GI anthrax infection, whereupon cleavage of mitogen-activated protein kinases (MAPKs) in immune cells may play a central role in promoting dysfunctional immune responses against this deadly pathogen.http://europepmc.org/articles/PMC4063899?pdf=render |
| spellingShingle | Yaíma L Lightfoot Tao Yang Bikash Sahay Mojgan Zadeh Sam X Cheng Gary P Wang Jennifer L Owen Mansour Mohamadzadeh Colonic immune suppression, barrier dysfunction, and dysbiosis by gastrointestinal bacillus anthracis Infection. PLoS ONE |
| title | Colonic immune suppression, barrier dysfunction, and dysbiosis by gastrointestinal bacillus anthracis Infection. |
| title_full | Colonic immune suppression, barrier dysfunction, and dysbiosis by gastrointestinal bacillus anthracis Infection. |
| title_fullStr | Colonic immune suppression, barrier dysfunction, and dysbiosis by gastrointestinal bacillus anthracis Infection. |
| title_full_unstemmed | Colonic immune suppression, barrier dysfunction, and dysbiosis by gastrointestinal bacillus anthracis Infection. |
| title_short | Colonic immune suppression, barrier dysfunction, and dysbiosis by gastrointestinal bacillus anthracis Infection. |
| title_sort | colonic immune suppression barrier dysfunction and dysbiosis by gastrointestinal bacillus anthracis infection |
| url | http://europepmc.org/articles/PMC4063899?pdf=render |
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