O-28 DRUG-INDUCED LIVER INJURY IN LATINAMERICA: First ten years’ experience of the ongoing LATINDILI Network
Introduction: In 2011, the Latin-American DILI-Network (LATINDILIN) set up under the guidance of the Spanish DILI Registry a network of hepatologists to prospectively identify and characterize DILI patients. Aim: To evaluate the drugs more frequently associated with DILI in LA, clinical phenotype an...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021-09-01
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| Series: | Annals of Hepatology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1665268121002143 |
| _version_ | 1818440341071593472 |
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| author | Fernando Bessone Nelia Hernandez Raymundo Parana Manuel Mendizabal Adriana Sanchez Vinicius Nunes Ezequiel Ridruejo Daniela Schiodi Genario Santos Eduardo Fassio Schinoni Maria I. Hugo Tanno Martin Tagle Pedro Montes Marco Arrese Nahum Mendez-Sanchez Javier Brahm Marcos Girala Isabel Lizarzábal M. Edgardo Mengual Enrique Carrera Fernando Contreras Inmaculada Medina-Caliz Mercedes Robles-Díaz Aida Ortega-Alonso Miren García-Cortes Ismael Alvarez-Alvarez Hao Niu Elvira Bonilla Isabel Lucena M. Andrade Raul J. |
| author_facet | Fernando Bessone Nelia Hernandez Raymundo Parana Manuel Mendizabal Adriana Sanchez Vinicius Nunes Ezequiel Ridruejo Daniela Schiodi Genario Santos Eduardo Fassio Schinoni Maria I. Hugo Tanno Martin Tagle Pedro Montes Marco Arrese Nahum Mendez-Sanchez Javier Brahm Marcos Girala Isabel Lizarzábal M. Edgardo Mengual Enrique Carrera Fernando Contreras Inmaculada Medina-Caliz Mercedes Robles-Díaz Aida Ortega-Alonso Miren García-Cortes Ismael Alvarez-Alvarez Hao Niu Elvira Bonilla Isabel Lucena M. Andrade Raul J. |
| author_sort | Fernando Bessone |
| collection | DOAJ |
| description | Introduction: In 2011, the Latin-American DILI-Network (LATINDILIN) set up under the guidance of the Spanish DILI Registry a network of hepatologists to prospectively identify and characterize DILI patients. Aim: To evaluate the drugs more frequently associated with DILI in LA, clinical phenotype and outcome. Methods: Demographics, clinical and biochemical parameters of all cases included in the LATINDILI Network were analysed according to the type of liver injury (hepatocellular, Hep; cholestatic, Chol and mixed, Mix). Results: 404 DILI cases were included. Anti-infectives (31%), musculoskeletal system drugs (13%) and herbal products (9.2%) were the main causative therapeutic drug classes. Mean age was 49 years (female sex, 61%). Hep injury predominated (62%) whereas Chol and Mix patterns were 24% and 15% of cases, respectively. Chol patients (mean age 56y) were older than Hep and Mix cases (47 and 50, p<0.05). Jaundice was more prevalent in Chol and Mix injury than in Hep cases (65% vs 75% vs 58%, respectively, p=0.062), though no differences in hospitalization rates were observed (Hep 43%, Chol and Mix 46%, p=0.867). Of note, 12 cases, mostly Hep, had a positive rechallenge. Positive autoantibodies were more common in Hep cases (25% vs Chol 9.1% vs Mix 19%, p=0.010), with nitrofurantoin/herbal products as the most common causative agents. Hep cases showed a higher risk of severe/fatal injury (18% vs 6.0% and 1.8% in Chol and Mix cases, respectively, p<0.001). The new Hy's law performed as expected, with 14% of ALF/Tx cases. Hep cases more frequently died from liver-related death (3.5%) compared with Chol (1.1%) and Mix (0) cases. Conclusions: In Latin-American DILI cases with Hep pattern predominated, showing a higher severity and most frequent inadvertent re-exposition. The LATINDILI Network is proving as an important tool for the characterization of DILI singularities in this world region, and improvement of Public Health. Funding: AEMPS, FEDER (PI18/01804). COST Action CA-17112. |
| first_indexed | 2024-12-14T18:10:49Z |
| format | Article |
| id | doaj.art-23e653d90e874e32a99531a1bb80ad74 |
| institution | Directory Open Access Journal |
| issn | 1665-2681 |
| language | English |
| last_indexed | 2024-12-14T18:10:49Z |
| publishDate | 2021-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Annals of Hepatology |
| spelling | doaj.art-23e653d90e874e32a99531a1bb80ad742022-12-21T22:52:18ZengElsevierAnnals of Hepatology1665-26812021-09-0124100515O-28 DRUG-INDUCED LIVER INJURY IN LATINAMERICA: First ten years’ experience of the ongoing LATINDILI NetworkFernando Bessone0Nelia Hernandez1Raymundo Parana2Manuel Mendizabal3Adriana Sanchez4Vinicius Nunes5Ezequiel Ridruejo6Daniela Schiodi7Genario Santos8Eduardo Fassio9Schinoni Maria I.10Hugo Tanno11Martin Tagle12Pedro Montes13Marco Arrese14Nahum Mendez-Sanchez15Javier Brahm16Marcos Girala17Isabel Lizarzábal M.18Edgardo Mengual19Enrique Carrera20Fernando Contreras21Inmaculada Medina-Caliz22Mercedes Robles-Díaz23Aida Ortega-Alonso24Miren García-Cortes25Ismael Alvarez-Alvarez26Hao Niu27Elvira Bonilla28Isabel Lucena M.29Andrade Raul J.30Hospital Provincial del Centenario, University of Rosario School of Medicine, Rosario, ArgentinaClínica de Gastroenterología, Hospital de Clínicas, Universidad de la República, Montevideo, UruguayHospital Universitário Prof. Edgard Santos-UFBA, Salvador, BrazilHospital Universitario Austral, Buenos Aires, ArgentinaClínica de Gastroenterología, Hospital de Clínicas, Universidad de la República, Montevideo, UruguayHospital Universitário Prof. Edgard Santos-UFBA, Salvador, BrazilCentro de Educación Médica e Investigaciones Clínicas, Buenos Aires, ArgentinaClínica de Gastroenterología, Hospital de Clínicas, Universidad de la República, Montevideo, UruguayHospital Universitário Prof. Edgard Santos-UFBA, Salvador, BrazilHospital Alejandro Posadas, Buenos Aires, ArgentinaHospital Universitário Prof. Edgard Santos-UFBA, Salvador, BrazilHospital Provincial del Centenario, University of Rosario School of Medicine, Rosario, ArgentinaClínica Anglo Americana, Lima, PerúHospital Nacional Daniel Alcides Carrion, Callao, PerúDepartamento de Gastroenterología. Facultad de Medicina Pontificia Universidad Católica de Chile, ChileFundación Clínica Médica Sur, Mexico City, MexicoHospital Clínico Universitario de Chile, ChileHospital de Clínicas, Asunción del Paraguay, ParaguayHospital Universitario de Maracaibo, Maracaibo, VenezuelaHospital Universitario de Maracaibo, Maracaibo, VenezuelaHospital de Especialidades Eugenio Espejo, Quito, EcuadorUniversidad Nacional Pedro Henriquez, Santo Domingo, República DominicanaServicios de Aparato Digestivo y Farmacología Clínica, Hospital Universitario Virgen de la Victoria, Instituto de Investigación Biomédica de Málaga-IBIMA, Universidad de Málaga, Málaga, Spain. CIBERehd, Madrid, SpainServicios de Aparato Digestivo y Farmacología Clínica, Hospital Universitario Virgen de la Victoria, Instituto de Investigación Biomédica de Málaga-IBIMA, Universidad de Málaga, Málaga, Spain. CIBERehd, Madrid, SpainServicios de Aparato Digestivo y Farmacología Clínica, Hospital Universitario Virgen de la Victoria, Instituto de Investigación Biomédica de Málaga-IBIMA, Universidad de Málaga, Málaga, Spain. CIBERehd, Madrid, SpainServicios de Aparato Digestivo y Farmacología Clínica, Hospital Universitario Virgen de la Victoria, Instituto de Investigación Biomédica de Málaga-IBIMA, Universidad de Málaga, Málaga, Spain. CIBERehd, Madrid, SpainServicios de Aparato Digestivo y Farmacología Clínica, Hospital Universitario Virgen de la Victoria, Instituto de Investigación Biomédica de Málaga-IBIMA, Universidad de Málaga, Málaga, Spain. CIBERehd, Madrid, SpainServicios de Aparato Digestivo y Farmacología Clínica, Hospital Universitario Virgen de la Victoria, Instituto de Investigación Biomédica de Málaga-IBIMA, Universidad de Málaga, Málaga, Spain. CIBERehd, Madrid, SpainServicios de Aparato Digestivo y Farmacología Clínica, Hospital Universitario Virgen de la Victoria, Instituto de Investigación Biomédica de Málaga-IBIMA, Universidad de Málaga, Málaga, Spain. CIBERehd, Madrid, SpainServicios de Aparato Digestivo y Farmacología Clínica, Hospital Universitario Virgen de la Victoria, Instituto de Investigación Biomédica de Málaga-IBIMA, Universidad de Málaga, Málaga, Spain. CIBERehd, Madrid, SpainServicios de Aparato Digestivo y Farmacología Clínica, Hospital Universitario Virgen de la Victoria, Instituto de Investigación Biomédica de Málaga-IBIMA, Universidad de Málaga, Málaga, Spain. CIBERehd, Madrid, SpainIntroduction: In 2011, the Latin-American DILI-Network (LATINDILIN) set up under the guidance of the Spanish DILI Registry a network of hepatologists to prospectively identify and characterize DILI patients. Aim: To evaluate the drugs more frequently associated with DILI in LA, clinical phenotype and outcome. Methods: Demographics, clinical and biochemical parameters of all cases included in the LATINDILI Network were analysed according to the type of liver injury (hepatocellular, Hep; cholestatic, Chol and mixed, Mix). Results: 404 DILI cases were included. Anti-infectives (31%), musculoskeletal system drugs (13%) and herbal products (9.2%) were the main causative therapeutic drug classes. Mean age was 49 years (female sex, 61%). Hep injury predominated (62%) whereas Chol and Mix patterns were 24% and 15% of cases, respectively. Chol patients (mean age 56y) were older than Hep and Mix cases (47 and 50, p<0.05). Jaundice was more prevalent in Chol and Mix injury than in Hep cases (65% vs 75% vs 58%, respectively, p=0.062), though no differences in hospitalization rates were observed (Hep 43%, Chol and Mix 46%, p=0.867). Of note, 12 cases, mostly Hep, had a positive rechallenge. Positive autoantibodies were more common in Hep cases (25% vs Chol 9.1% vs Mix 19%, p=0.010), with nitrofurantoin/herbal products as the most common causative agents. Hep cases showed a higher risk of severe/fatal injury (18% vs 6.0% and 1.8% in Chol and Mix cases, respectively, p<0.001). The new Hy's law performed as expected, with 14% of ALF/Tx cases. Hep cases more frequently died from liver-related death (3.5%) compared with Chol (1.1%) and Mix (0) cases. Conclusions: In Latin-American DILI cases with Hep pattern predominated, showing a higher severity and most frequent inadvertent re-exposition. The LATINDILI Network is proving as an important tool for the characterization of DILI singularities in this world region, and improvement of Public Health. Funding: AEMPS, FEDER (PI18/01804). COST Action CA-17112.http://www.sciencedirect.com/science/article/pii/S1665268121002143 |
| spellingShingle | Fernando Bessone Nelia Hernandez Raymundo Parana Manuel Mendizabal Adriana Sanchez Vinicius Nunes Ezequiel Ridruejo Daniela Schiodi Genario Santos Eduardo Fassio Schinoni Maria I. Hugo Tanno Martin Tagle Pedro Montes Marco Arrese Nahum Mendez-Sanchez Javier Brahm Marcos Girala Isabel Lizarzábal M. Edgardo Mengual Enrique Carrera Fernando Contreras Inmaculada Medina-Caliz Mercedes Robles-Díaz Aida Ortega-Alonso Miren García-Cortes Ismael Alvarez-Alvarez Hao Niu Elvira Bonilla Isabel Lucena M. Andrade Raul J. O-28 DRUG-INDUCED LIVER INJURY IN LATINAMERICA: First ten years’ experience of the ongoing LATINDILI Network Annals of Hepatology |
| title | O-28 DRUG-INDUCED LIVER INJURY IN LATINAMERICA: First ten years’ experience of the ongoing LATINDILI Network |
| title_full | O-28 DRUG-INDUCED LIVER INJURY IN LATINAMERICA: First ten years’ experience of the ongoing LATINDILI Network |
| title_fullStr | O-28 DRUG-INDUCED LIVER INJURY IN LATINAMERICA: First ten years’ experience of the ongoing LATINDILI Network |
| title_full_unstemmed | O-28 DRUG-INDUCED LIVER INJURY IN LATINAMERICA: First ten years’ experience of the ongoing LATINDILI Network |
| title_short | O-28 DRUG-INDUCED LIVER INJURY IN LATINAMERICA: First ten years’ experience of the ongoing LATINDILI Network |
| title_sort | o 28 drug induced liver injury in latinamerica first ten years experience of the ongoing latindili network |
| url | http://www.sciencedirect.com/science/article/pii/S1665268121002143 |
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