Choroid-Plexus-Derived Otx2 Homeoprotein Constrains Adult Cortical Plasticity
Brain plasticity is often restricted to critical periods in early life. Here, we show that a key regulator of this process in the visual cortex, Otx2 homeoprotein, is synthesized and secreted globally from the choroid plexus. Consequently, Otx2 is maintained in selected GABA cells unexpectedly throu...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2013-06-01
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| Series: | Cell Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124713002313 |
| _version_ | 1818211434938499072 |
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| author | Julien Spatazza Henry H.C. Lee Ariel A. Di Nardo Lorenzo Tibaldi Alain Joliot Takao K. Hensch Alain Prochiantz |
| author_facet | Julien Spatazza Henry H.C. Lee Ariel A. Di Nardo Lorenzo Tibaldi Alain Joliot Takao K. Hensch Alain Prochiantz |
| author_sort | Julien Spatazza |
| collection | DOAJ |
| description | Brain plasticity is often restricted to critical periods in early life. Here, we show that a key regulator of this process in the visual cortex, Otx2 homeoprotein, is synthesized and secreted globally from the choroid plexus. Consequently, Otx2 is maintained in selected GABA cells unexpectedly throughout the mature forebrain. Genetic disruption of choroid-expressed Otx2 impacts these distant circuits and in the primary visual cortex reopens binocular plasticity to restore vision in amblyopic mice. The potential to regulate adult cortical plasticity through the choroid plexus underscores the importance of this structure in brain physiology and offers therapeutic approaches to recovery from a broad range of neurodevelopmental disorders. |
| first_indexed | 2024-12-12T05:32:27Z |
| format | Article |
| id | doaj.art-23e7f4b5cf804284bd12e0fc37de65d8 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-12-12T05:32:27Z |
| publishDate | 2013-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-23e7f4b5cf804284bd12e0fc37de65d82022-12-22T00:36:17ZengElsevierCell Reports2211-12472013-06-01361815182310.1016/j.celrep.2013.05.014Choroid-Plexus-Derived Otx2 Homeoprotein Constrains Adult Cortical PlasticityJulien Spatazza0Henry H.C. Lee1Ariel A. Di Nardo2Lorenzo Tibaldi3Alain Joliot4Takao K. Hensch5Alain Prochiantz6Development and Neuropharmacology Group, College de France, Centre for Interdisciplinary Research in Biology, CNRS UMR 7241, Labex Memolife, PSL Research University, 11 Place Marcelin Berthelot, 75005 Paris, FranceFM Kirby Neurobiology Center, Boston Children’s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USADevelopment and Neuropharmacology Group, College de France, Centre for Interdisciplinary Research in Biology, CNRS UMR 7241, Labex Memolife, PSL Research University, 11 Place Marcelin Berthelot, 75005 Paris, FranceHomeoprotein Cell Biology Group, College de France, Centre for Interdisciplinary Research in Biology, CNRS UMR 7241, Labex Memolife, PSL Research University, 11 Place Marcelin Berthelot, 75005 Paris, FranceHomeoprotein Cell Biology Group, College de France, Centre for Interdisciplinary Research in Biology, CNRS UMR 7241, Labex Memolife, PSL Research University, 11 Place Marcelin Berthelot, 75005 Paris, FranceFM Kirby Neurobiology Center, Boston Children’s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USADevelopment and Neuropharmacology Group, College de France, Centre for Interdisciplinary Research in Biology, CNRS UMR 7241, Labex Memolife, PSL Research University, 11 Place Marcelin Berthelot, 75005 Paris, FranceBrain plasticity is often restricted to critical periods in early life. Here, we show that a key regulator of this process in the visual cortex, Otx2 homeoprotein, is synthesized and secreted globally from the choroid plexus. Consequently, Otx2 is maintained in selected GABA cells unexpectedly throughout the mature forebrain. Genetic disruption of choroid-expressed Otx2 impacts these distant circuits and in the primary visual cortex reopens binocular plasticity to restore vision in amblyopic mice. The potential to regulate adult cortical plasticity through the choroid plexus underscores the importance of this structure in brain physiology and offers therapeutic approaches to recovery from a broad range of neurodevelopmental disorders.http://www.sciencedirect.com/science/article/pii/S2211124713002313 |
| spellingShingle | Julien Spatazza Henry H.C. Lee Ariel A. Di Nardo Lorenzo Tibaldi Alain Joliot Takao K. Hensch Alain Prochiantz Choroid-Plexus-Derived Otx2 Homeoprotein Constrains Adult Cortical Plasticity Cell Reports |
| title | Choroid-Plexus-Derived Otx2 Homeoprotein Constrains Adult Cortical Plasticity |
| title_full | Choroid-Plexus-Derived Otx2 Homeoprotein Constrains Adult Cortical Plasticity |
| title_fullStr | Choroid-Plexus-Derived Otx2 Homeoprotein Constrains Adult Cortical Plasticity |
| title_full_unstemmed | Choroid-Plexus-Derived Otx2 Homeoprotein Constrains Adult Cortical Plasticity |
| title_short | Choroid-Plexus-Derived Otx2 Homeoprotein Constrains Adult Cortical Plasticity |
| title_sort | choroid plexus derived otx2 homeoprotein constrains adult cortical plasticity |
| url | http://www.sciencedirect.com/science/article/pii/S2211124713002313 |
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