Choroid-Plexus-Derived Otx2 Homeoprotein Constrains Adult Cortical Plasticity

Choroid-Plexus-Derived Otx2 Homeoprotein Constrains Adult Cortical Plasticity

Brain plasticity is often restricted to critical periods in early life. Here, we show that a key regulator of this process in the visual cortex, Otx2 homeoprotein, is synthesized and secreted globally from the choroid plexus. Consequently, Otx2 is maintained in selected GABA cells unexpectedly throu...

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Bibliographic Details
Main Authors: Julien Spatazza, Henry H.C. Lee, Ariel A. Di Nardo, Lorenzo Tibaldi, Alain Joliot, Takao K. Hensch, Alain Prochiantz
Format: Article
Language:English
Published: Elsevier 2013-06-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124713002313

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